Objective of this study was evaluation therapeutic efficacy and adverse effects of the combined treatment in patients with partial epilepsy comorbid with depressive and anxiety disorders. Patients were treated with antiepileptic drugs (AED) as monotherapy before and during the investigation. Patients of group 1 (42 cases) were administrated sertraline (SER) 100 mg per day in combination with pregabalin (PGB) 300 mg per day in addition to basic AED. Patients of group 2 (41 cases) were treated with SER 100 mg per day in addition to basic AED. The duration of the investigation has made 6 months. In this study several characteristics had been evaluated in each group: seizure frequency, severity of depressive and anxiety disorders, adverse effects of the drugs administrated. Moreover, dynamics of types of attitude to the disease were investigated under the drugs administration in each group. SER and PGB demonstrated high efficacy and safety in treatment partial epilepsy comorbid with depressive and anxiety disorders. PGB must be recommended in adjunctive therapy of anxiety disorders in patients with partial epilepsy.