The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Rogatkin S.O.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Degtiareva M.G.

Grebennikova O.V.

Volodin N.N.

Sigova Iu.A.

Asmolova G.A.

Serova N.D.

Clinical-encephalographic evaluation of preterm children treated with cytoflavin during the first year of life

Authors:

Rogatkin S.O., Degtiareva M.G., Grebennikova O.V., Volodin N.N., Sigova Iu.A., Asmolova G.A., Serova N.D.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(5): 16‑23

Read: 1470 times

Download PDF (RU)
Contact the author
Table of contents

CLINICAL-ENCEPHALOGRAPHIC EVALUATION OF PRETERM CHILDREN TREATED WITH CYTOFLAVIN DURING THE FIRST YEAR OF LIFE
CLINICAL-ENCEPHALOGRAPHIC EVALUATION OF PRETERM CHILDREN TREATED WITH CYTOFLAVIN DURING THE FIRST YEAR OF LIFE

To cite this article:

Rogatkin SO, Degtiareva MG, Grebennikova OV, Volodin NN, Sigova IuA, Asmolova GA, Serova ND. Clinical-encephalographic evaluation of preterm children treated with cytoflavin during the first year of life. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(5):16‑23. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Adju­vant pharmacological modu­lation with Cyto­flavin in reha­bilitation at stages 2—3 in patients with acute cere­bral insu­fficiency and post-intensive care syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):78-85
Cognitive impairment after major surgical operations. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):74-80
Clinical and instrumental diagnostics of facial neuropathy in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):31-36
Comparative study of the neuroprotective effe­cts of the drug Cyto­flavin and citi­coline in a rats model of hemo­rrhagic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):85-95
Oxidative stress and depression in Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):131-138
Resu­lts of the obse­rvational program CITO­TREK (use of the drug CITO­flavin in Tablets) in patients with tension headaches against the backgRound of asthenic syndromE taKing into account como­rbidity. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(10):104-112
Evaluation of the effe­ctiveness of the drug cyto­flavin to improve adaptation to physical acti­vity in athletes with minor cardiac anomalies. Russian Journal of Preventive Medi­cine. 2025;(5):90-95
Open-access data­bases in anesthesiology and inte­nsive care: a systematic review and guidelines. Russian Journal of Anesthesiology and Reanimatology. 2025;(4):61-71
Dyna­mics of microbial colo­nization in various biotopes of preterm neonates with extremely low and very low birth weight: a pilot study. Russian Journal of Evidence-Based Gastroenterology. 2025;(3):35-43
Correction of postoperative meta­bolic diso­rders after radiofrequency abla­tion for atrial fibrillation. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(6):680-684
Abstract:

An aim of the study was the clinical and neurophysiological evaluation of the effect of cytoflavin and reanimation measures on the rate of nervous and mental development of preterm newborns with cerebral ischemia, II-III stage, during the first year of life. One hundred and twenty children with gestational age 28-36 weeks and body mass 1060-3150 g were studied. In the main group (n=61), the complex treatment included cytoflavin in dosage 2 ml/kg/day, intravenously during 5 days. The control group (n=59) received basic treatment without cytoflavin. The follow-up till the age of 1 year comprised the global assessment of state and neurological status using quantitative measurements of muscle postural tone on the INFANIB scale, psychomotor development (BSID-II) and assessment of CNS functional state by analyzing computed EEG signals during physiological sleep. The results obtained demonstrated the fast normalization of all studied measures of development of children treated with cytoflavin compared to those of the control group.

Keywords:

preterm newborns
intensive therapy
cerebral hypoxia-ischemia
cerebroprotective therapy
nervous-mental development
computed electroencephalography
cytoflavin

Authors:

Rogatkin S.O.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Degtiareva M.G.

Grebennikova O.V.

Volodin N.N.

Sigova Iu.A.

Asmolova G.A.

Serova N.D.

Close metadata

References:

  1. Bul'on V.V., Khnychenko L.S., Sapronov N.S. Korrektsiya posledstvii postishemicheskogo reperfuzionnogo povrezhdeniya golovnogo mozga tsitoflavinom. Byulleten' eksperimental'noi biologii i meditsiny 2000; 129: 2: 149-151.
  2. Vasil'ev S.Ts. Effektivnost' primeneniya yantarnoi kisloty v kompleksnom lechenii detei s mitokhondrial'nymi entsefalomiopatiyami i s drugimi zabolevaniyami s mitokhondrial'noi disfunktsiei: Avtoref. dis. … kand. med. nauk. M 2002.
  3. Volodin N.N., Medvedev M.I., Rogatkin S.O. Perinatal'naya entsefalopatiya i ee posledstviya - diskussionnye voprosy semiotiki, rannei diagnostiki i terapii. Ros pediatr zhurn 2001; 1: 4-8.
  4. Volodin N.N., Degtyarev D.N. Printsipy vykhazhivaniya detei s ekstremal'no nizkoi massoi tela. Voprosy ginekologii, akusherstva i perinatologii 2003; 2: 2: 64-69.
  5. Golosnaya G.S. Rol' ingibitorov apoptoza v diagnostike i prognozirovanii iskhodov perinatal'nykh gipoksicheskikh porazhenii golovnogo mozga u novorozhdennykh. Pediatriya 2005; 3: 30-36.
  6. Degtyareva M.G., Rogatkin S.O., Voron O.A., Volodin N.N. Ekspertnaya otsenka EEG fiziologicheskogo sna u nedonoshennykh detei razlichnogo gestatsionnogo vozrasta s perinatal'nymi porazheniyami TsNS. Voprosy prakticheskoi pediatrii 2006; 5: 1: 5-13.
  7. Kondrasheva M.N. Mekhanizmy fiziologicheskoi aktivnosti yantarnoi kisloty i rekomendatsii k ee primeneniyu. Klinicheskie i patogeneticheskie problemy narusheniya kletochnoi energetiki (mitokhondrial'naya patologiya). M 1999; 33-34.
  8. Lazarev V.V., Lekmanov A.U., Mikhel'son V.A. Primenenie reamberina - 1,5% rastvora dlya infuzii pri intensivnoi terapii i anestezii u detei. Metodicheskoe posobie. M 2003; 17-23.
  9. Livanov G.A., Batotsyrenova Kh.V., Glushkov S.I. i dr. Ispol'zovanie metabolicheskogo antigipoksanta tsitoflavina pri korrektsii gipoksii i ee posledstvii pri tyazhelykh formakh ostrykh otravlenii neirotropnymi yadami. Detoksikatsiya. Vestn intensivnoi terapii 2005; 1: 60-63.
  10. Sakharova E.S., Keshishyan E.S., Alyamovskaya G.A. Osobennosti psikhomotornogo razvitiya nedonoshennykh detei, rozhdennykh s massoi tela menee 1000 g. Rossiiskii vestnik perinatologii i pediatrii 2002; 4: 20-24.
  11. Sokolova N.A., Maslova M.V., Maklakova A.S., Ashmarin I.P. Prenatal'nyi gipoksicheskii stress: Fiziologicheskie i biokhimicheskie posledstviya, korrektsiya regulyatornymi peptidami. Uspekhi fiziol nauk 2002; 33: 2: 56-67.
  12. Stroganova T.A., Degtyareva M.G., Volodin N.N. Elektroentsefalografiya v neonatologii. Pod obshchei redaktsiei akademika RAMN
  13. Shabalov N.P., Lyubimenko V.A., Pal'chik A.B., Yaroslavskii V.K. Asfiksiya novorozhdennykh. M: Medpress-inform 2003; 367.
  14. Yatsyk G.V., Bombardirova E.P., Tresorukova O.V. Vykhazhivanie i rannyaya reabilitatsiya detei. Lechashchii vrach 2007; 7: 10-12.
  15. Allen M.C. Neurodevelopmental outcomes of preterm infants. Curr Opin Neurol 2008; 21: 2: 123-128.
  16. Bayley N. Bayley scales of infant development. 2end Manual. N.Y.: The Psychological corporation 1993.
  17. Elisson P. The neurological examination of newborn and infant. Pediatric Neurology for the clinician. Ed R.B. David 1995; 19-64.
  18. Giacoia G. Asphyxial brain damage in the newborn: new insights into the pathology and possible pharmacologic interventions. South Med J 1993; 86: 676-682.
  19. Hossain M.A. Molecular mediators of hypoxic-ischemic injury and implications for epilepsy in the developing brain. Epilepsy Behav 2005; 7: 2: 204-213.
  20. Volpe J.J. Neurology of the newborn. Philadelphia: W.B. Saunders Company. 5-th ed 2008; 1120.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.