A search for new markers of oxidative stress in brain ischemia for the optimization of treatment approaches

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Data of literature on the role of inflammation factors in the pathogenesis of stroke are presented. The study of myeloperoxidase level in the early acute phase of ischemic stroke and dynamics of this parameter after the antioxidant treatment with the α-lipoic acid preparation berlition was carried out. It has been shown that the activation of systemic inflammation and related oxidative stress recorded in the early acute phase of brain infarction needs pharmacological treatment. Neuroprotective action of α-lipoic acid related to the prevention of damaging effect of free radicals on cell membranes and reduction of oxidative stress intensity is a pathogenetic explanation for using its preparations in ischemic brain lesions. The decrease in plasma myeloperoxidase content after the treatment with berlition may consider as a criterion of its efficacy.

Keywords:

brain ischemia

brain infarction

risk factors

cerebrovascular diseases

myeloperoxidase

oxidative stress

α-lipoic acid

Authors:

Baranova O.A.

Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova;
Nauchno-issledovatel'skiĭ institut fiziko-khimicheskoĭ meditsiny FMBA Rossii, laboratoriia fiziko-khimicheskikh metodov issledovaniia i analiza, Moskva

Chekanov A.V.

Karneev A.N.

Mironova O.P.

Miachin I.V.

Panasenko O.M.

Solov'eva É.Iu.

Kafedra nevrologii FUV GOU VPO RGMU, Moskva

Fedin A.I.

Kafedra nevrologii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

RSCI AuthorID: 167799
Scopus AuthorID: 7007163263
ORCID: 0000-0002-6996-2828

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