The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Baranova O.A.

N.I. Pirogov Russian National Research Medical University

Chekanov A.V.

Karneev A.N.

Mironova O.P.

Miachin I.V.

Panasenko O.M.

Solov'eva É.Iu.

Kafedra nevrologii FUV GOU VPO RGMU, Moskva

Fedin A.I.

Kafedra nevrologii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

A search for new markers of oxidative stress in brain ischemia for the optimization of treatment approaches

Authors:

Baranova O.A., Chekanov A.V., Karneev A.N., Mironova O.P., Miachin I.V., Panasenko O.M., Solov'eva É.Iu., Fedin A.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(12): 25‑31

Read: 1121 times

Download PDF (RU)
Contact the author
Table of contents

A SEARCH FOR NEW MARKERS OF OXIDATIVE STRESS IN BRAIN ISCHEMIA FOR THE OPTIMIZATION OF TREATMENT APPROACHES
A SEARCH FOR NEW MARKERS OF OXIDATIVE STRESS IN BRAIN ISCHEMIA FOR THE OPTIMIZATION OF TREATMENT APPROACHES

To cite this article:

Baranova OA, Chekanov AV, Karneev AN, et al. . A search for new markers of oxidative stress in brain ischemia for the optimization of treatment approaches. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(12):25‑31. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Oxidative stress in the pathogenesis of chro­nic headache. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):35-40
Stru­ctural and functional features of the main arte­ries of the brain and tumor necrosis factor-alpha in people with chro­nic non-infectious diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):178-184
Modern aspe­cts of chro­nic cere­bral ischemia pathogenetic therapy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):106-113
Oxidative stress and antioxidant protection in diso­rders of cere­bral circulation. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):114-119
Risk factors asso­ciated with myopic macu­lopathy in acquired myopia. Russian Annals of Ophthalmology. 2024;(5):35-45
Rationale for the use of non-linear statistical methods in the analysis of rela­tionships between risk factors and fatal events acco­rding to the data of long-term prospective obse­rvation in popu­lation of Russia and the United States of America. Russian Journal of Preventive Medi­cine. 2024;(11):34-39
Features of como­rbidity pathology in young people. Russian Journal of Preventive Medi­cine. 2024;(11):63-69
Comparison of models for prediction of spontaneous preterm birth. Medi­cal Technologies. Asse­ssment and Choice. 2024;(4):10-19
Alte­rations in the acti­vity of glutathione-dependent enzy­mes in erythrocytes of patients with acute pancreatitis of varying seve­rity. Russian Journal of Evidence-Based Gastroenterology. 2024;(4):10-15
Gastric cancer: inci­dence, risk factors, screening. Russian Journal of Preventive Medi­cine. 2024;(12):135-139
Abstract:

Data of literature on the role of inflammation factors in the pathogenesis of stroke are presented. The study of myeloperoxidase level in the early acute phase of ischemic stroke and dynamics of this parameter after the antioxidant treatment with the α-lipoic acid preparation berlition was carried out. It has been shown that the activation of systemic inflammation and related oxidative stress recorded in the early acute phase of brain infarction needs pharmacological treatment. Neuroprotective action of α-lipoic acid related to the prevention of damaging effect of free radicals on cell membranes and reduction of oxidative stress intensity is a pathogenetic explanation for using its preparations in ischemic brain lesions. The decrease in plasma myeloperoxidase content after the treatment with berlition may consider as a criterion of its efficacy.

Keywords:

brain ischemia
brain infarction
risk factors
cerebrovascular diseases
myeloperoxidase
oxidative stress
α-lipoic acid

Authors:

Baranova O.A.

N.I. Pirogov Russian National Research Medical University

Chekanov A.V.

Karneev A.N.

Mironova O.P.

Miachin I.V.

Panasenko O.M.

Solov'eva É.Iu.

Kafedra nevrologii FUV GOU VPO RGMU, Moskva

Fedin A.I.

Kafedra nevrologii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

Close metadata

References:

  1. Borisov A.V., Semak A.E. Rol' immunnykh i vospalitel'nykh faktorov v patogeneze insul'ta. Klinicheskaya meditsina 2005; 83: 10.
  2. Vladimirov Yu.L., Kreinina M.V., Klebanov G.I., Ribarov S.R., Bochev P.G., Benov L.Ts. Vliyanie okislennykh fosfolipidov liposomal'nykh membran na aktivnost' polimorfno-yadernykh leikotsitov krovi. Biol membrany 1988; 5: 11: 1072.
  3. Gusev E.I., Skvortsova V.I. Ishemiya golovnogo mozga. M: Meditsina 2001; 328.
  4. Demchenko I.T. i dr. Giperbaricheskii kislorod ingibiruet infil'tratsiyu neitrofilov i oslablyaet postishemicheskoe porazhenie mozga u krys. Rossiiskii fiziologicheskii zhurnal 2001; 8: 1118-1125.
  5. Domingez K. i dr. Oksidantnyi stress posle trombolizis-indutsirovannoi reperfuzii pri insul'te u lyudei. Stroke (Insul't) 2010; 5-6.
  6. Karli F. Metabolicheskii otvet na ostryi stress. Aktual'nye problemy anesteziologii-reanimatologii. Pod red. prof. E.V. Nedashkovskogo. Arkhangel'sk 1997; 31-34.
  7. Petrishchev N.E., Vlasov T.D. Funktsional'noe sostoyanie endoteliya pri ishemii-reperfuzii: Obzor literatury. Ros fiziol zhurn 2000; 86: 2: 148-163.
  8. Rubtsov B.V., Klebanov G.I., Ruzhitskii A.O., Vladimirov Yu.A. Sravnenie deistviya UF-izlucheniya i Fe2+-indutsirovannogo perekisnogo okisleniya lipidov na membrany sarkoplazmaticheskogo retikuluma. Izv. AN SSSR. Ser biol 1984; 2: 299.
  9. Suslina Z.A., Fedorova T.N., Maksimova M.Yu. i dr. Antioksidantnaya terapiya pri ishemicheskom insul'te. Zhurn nevrol i psikhiat 2000; 100: 190: 34-38.
  10. Chesnokova N.P., Morrison V.V., Kudin G.B. Nedostatochnost' antioksidantnoi sistemy kak vedushchii faktor dezorganizatsii pri bakterial'nykh infektsiyakh i intoksikatsiyakh. Materialy Vserossiiskoi nauchnoi konferentsii, posvyashchennoi 150-letiyu so dnya rozhdeniya I.P. Pavlova. St-Peterburg 1999; 27-28.
  11. Shepelev A.P., Kornienko I.V., Shestopalov, A.V., Antipov A.Yu. Rol' protsessov svobodnoradikal'nogo okisleniya v patogeneze infektsionnykh boleznei. Voprosy meditsinskoi khimii 2000; 2: 54-59.
  12. Arundinc M., Tymianski M. Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium 2003; 34: 325-337.
  13. Baldus S., Heeschen C. et al. Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation 2003; 108: 1440.
  14. Baldus S., Heitzer T., Eiserich J.P. et al. Myeloperoxidase enhances nitric oxide catabolism during myocardial ischemia and reperflision. Free Radic Biol Med 2004; 37: 902.
  15. Barabom V.A. Alpha-lipoic-dihydrolipoic acids - active bioantioxidant and bioregulatory system. Ukr Biokhim Zh 2005; 77: 3: 20-26.
  16. Beamer N.B., Sexton G., Wym M. et al. Persistent inflammatory response in stroke survivors. Neurology 1998; 50: 6: 1722-1728.
  17. Behrendt D., Ganz P. Endothelial function. From vascular biology to clinical applications. Am J Cardiol 2002; 21: 40-48.
  18. Biewenga G.P., Haenen G.R., Bast A. Gen The pharmacology of the antioxidant lipoic acid. Pharmacol 1997; 29: 3: 315-331.
  19. Breckwoldt M.O., Chen J.W., Stangenberg L., Aikawa E., Rodriguez E., Qiu S., Moskowitz M.A., Weissleder R. Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase. Proc Natl Acad Sci USA 2008; 105: 47: 18584-18589.
  20. Brennan M.L., Penn M.S., Van Lente F. Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med 2003; 349: 1595.
  21. Carr A.C. Hypochlorous acid-modified low-density lipoprotein inactivates the lysosomal protease cathepsin B: protection by ascorbic and lipoic acids. Redox Rep 2001; 6: 6: 343-349.
  22. Doyle K.P., Simon R.P., Stenzel-Poore M.P. Mechanisms of ischemic brain damage. Neuropharmacology 2008; 55: 310-318.
  23. Dugan L.L., Kim-Han J.S. Hypoxic-ischemic brain injury and oxidative stress. Eds. Siegel G., Albers R.W., Brady S. et al. Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 7th ed. New York, NY: Academic Press an imprint of Elsevier 2006; 559-574.
  24. Goraca A, Piechota A, Huk-Kolega H. Effect of alpha-lipoic acid on LPS-induced oxidative stress in the heart. J Physiol Pharmacol 2009; 60: 1: 61-68.
  25. Grau A.J., Buggle F., Hacke W. Infectious diseases as a cause and risk factor for cerebrovascular ischemia. Nervenarzt 1996; 67: 8: 639-649.
  26. Hazen S.L. Mueloperoxidase and plaque vulnerability. Arterioscler Thromb Vasc Biol 2004; 24: 1143.
  27. Kannel W.B., Wolf P.A. Framingham Study insights on the hazards of elevated blood pressure. JAMA 2008; 3: 21: 2545-2547.
  28. Kass I.S., Cottrell J.E. Pathophysiology of brain injury. Eds. Cottrell J.E., Smith D.S. Anesthesia and Neurosurgery. 4th ed. St. Louis, MO: Mosby 2001; 69-82.
  29. Libby P., Sukhova G., Lee R.T., Galis Z.S. Cytokines regulate vascular functions related to stability of the atherosclerotic plaque. J Cardiovasc Pharmacol 1995; 25: 9-12.
  30. Malińska D., Winiarska K. Lipoic acid: characteristics and therapeutic application. Postepy Hig Med Dosw 2005; 59: 535-543.
  31. Marsche G., Hammer A. et al. Hypochlorite-modified high density lipoprotein, a high affinity ligand to scavenger receptor class B, type I, impairs high density lipoprotein-dependent selective lipid uptake and reverse cholesterol transport. J Biol Chem 2002; 277: 32172.
  32. Mattila K.J., Valtonen V.V., Nieminen M.S., Asikainen S. Role of infection as a risk factor for atherosclerosis, myocardial infarction, and stroke. Clin Infect Dis 1998; 26: 3: 719-734.
  33. Moini H., Packer L., Saris N.E. Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol Appl Pharmacol 2002; 182: 1: 84-90.
  34. Murphy S., Gibson C.L. Nitric oxide, ishaemia and brain inflammation. Biochem Soc Trans 2007; 35: 1133-1137.
  35. Naccache P.H., Sha'afi R.I. Granulocyte activation. Biochemical events associated with the mobilization of calcium. Surv Immunol Res 1984; 3: 4: 288-294.
  36. Podrez E.A., Poliakov E. et al. A Novel Family of Atherogenic Oxidized Phospholipids Promotes Macrophage Foam Cell Formation via the Scavenger Receptor CD36 and Is Enriched in Atherosclerotic Lesions. J Biol Chem 2002; 277: 38517.
  37. Ramos L.F., Kane J., McMonagle E., Le P., Wu P., Shintani A., Ikizler T.A., Himmelfarb J. Effects of combination tocopherols and alpha lipoic acid therapy on oxidative stress and inflammatory biomarkers in chronic kidney disease. J Ren Nutr 2011; 21: 3: 211-218.
  38. Rodriguez-Yanez M., Castillo J. Role of inflammatory markers in brain ischemia. Curr Opin Neurol 2008; 21: 3: 353-357.
  39. Rossi A., Franceschini L., Fusaro M., Cicoira M., Eleas A.A., Golia G. et al. Carotid atherosclerotic plaque instability in patients with acute myocardial infarction. Int J Cardiol 2006; 111: 263-266.
  40. Scott B.C., Aruoma O.I., Evans P.J., O'Neill C., Van der Vliet A., Cross C.E., Tritschler H., Halliwell B. Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation. Free Radic Res 1994; 20: 2: 119-133.
  41. Singh U., Jialal I. Alpha-lipoic acid supplementation and diabetes. Nutr Rev 2008; 66: 11: 646-657.
  42. Stefanescu A., Braun S., Ndrepepa G., Koppara T., Pavaci H., Mehilli J. et al. Prognostic value of plasma myeloperoxidase concentration in patients with stable coronary artery disease. Am Heart J 2008; 155: 356-360.
  43. et al. STONE, Syst-Eur, NICS, PROGRESS.
  44. Sugiyama S., Okada Y., Sukhova G.K. Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes. Am J Pathol 2001; 158: 79.
  45. Weston R.M., Jones N.M., Jarrott B., Callaway J.K. Inflammatory cell infiltration after endothelin-1-induced cerebral ischemia: histochemical and myeloperoxidase correlation with temporal changes in brain injury. J Cereb Blood Flow Metab 2007; 1: 100-114.
  46. Wisniewski H.M., Wegiel J., Wang K.C., Kujawa M., Lach B. Ultrastructural studies of the cells forming amyloid fibers in classical plaques. Can J Neurol Sci 1989; 16: 535-542.
  47. Wolin M.S. Interactions of oxidants with vascular signaling systems. Arterioscler Thromb Vasc Biol 2000; 20: 6: 1430-1442.
  48. Wong C.H., Crack P.J. Modulation of Neuro-Inflammation and Vascular Response by Oxidative Stress Following Cerebral Ischemia-Reperfusion Injury Curr Med Chem 2008; 15: 1: .1-14.
  49. Zhang R., Brennan M.L., Fu X. Association between myeloperoxidase levels and risk of coronary artery disease. JAMA 2001; 286: 2136.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.