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Panova I.A.

Ivanovo Scientific Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Rokotyanskaya E.A.

Ivanovo Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Khizrieva Z.S.

Ivanovo Scientific Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Medical and biological risk factors for the development of pre-eclampsia of variable severity in pregnant women with chronic arterial hypertension

Authors:

Panova I.A., Rokotyanskaya E.A., Khizrieva Z.S.

More about the authors

Journal: Russian Journal of Human Reproduction. 2024;30(3): 77‑84

DOI: 10.17116/repro20243003177

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Table of contents

MEDICAL AND BIOLOGICAL RISK FACTORS FOR THE DEVELOPMENT OF PRE-ECLAMPSIA OF VARIABLE SEVERITY IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION
MEDICAL AND BIOLOGICAL RISK FACTORS FOR THE DEVELOPMENT OF PRE-ECLAMPSIA OF VARIABLE SEVERITY IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION

To cite this article:

Panova IA, Rokotyanskaya EA, Khizrieva ZS. Medical and biological risk factors for the development of pre-eclampsia of variable severity in pregnant women with chronic arterial hypertension. Russian Journal of Human Reproduction. 2024;30(3):77‑84. (In Russ.)
https://doi.org/10.17116/repro20243003177

 
Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

INTRODUCTION

Preeclampsia (PE) develops in 20% of women with chronic arterial hypertension (CAH). This is associated with increased maternal and perinatal morbidity compared to de novo PE. There are no data on risk factors for the addition of PE of varying severity to CAH, which confirms the relevance of this study.

THE AIM OF THE STUDY

Was to clarify the medical and biological risk factors for the development of preeclampsia of varying severity in patients with CAH.

METHODS

Clinical and statistical. Data were copied from medical records. The study was conducted with the participation of 254 patients (147 pregnant women with CAH, 62 with moderate preeclampsia on the background of CAH, 45 with severe preeclampsia on the background of CAH). The quantitative description of the values with a normal distribution was carried out using an arithmetic value and an arithmetic mean error (M±m).

RESULTS

Risk factors for the addition of moderate and severe PE to CAH, determined in the 1st trimester of pregnancy, are: stage 2 hypertension (OR=2.1; 95% CI 1.7—6.2; OR=3.1; 95% CI 2.8—7.4) with target organ damage, retinal angiopathy I b degree (OR=4.0; 95% CI 3.6—16.9; OR=1.8; 95% CI 1.2—5.3), urinary tract infections in history (OR=2.32; 95% CI 1.7—6.4; OR=3.2; 95% CI 2.4—10.4), mean BP above 95 mmHg. upon registration (OR=3.2; 95% CI 1.5—14.9; OR=4.9; 95% CI 1.7—41.2). Additional risk factors for moderate PE are unregistered marriage (OR=1.6; 95% CI 1.05—4.1), smoking (OR=2.3; 95% CI 1.2—18.2), irregular use antihypertensive drugs before pregnancy (OR=1.7; 95% CI 1.2—4.1); severe PE — no antihypertensive therapy in the 1st trimester of pregnancy (OR=2.3; 95% CI 1.5—6.4), duration of hypertension for more than 5 years (OR=3.3; 95% CI 1.2—4, 1), preeclampsia in the anamnesis (OR=2.0; 95% CI 1.3—5.5).

CONCLUSION

Timely correction of modifiable risk factors and prevention of PE will improve maternal and perinatal outcomes in women with CAH.

Keywords:

chronic arterial hypertension
preeclampsia of varying severity
risk factors

Authors:

Panova I.A.

Ivanovo Scientific Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Rokotyanskaya E.A.

Ivanovo Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Khizrieva Z.S.

Ivanovo Scientific Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Received:

22.05.2023

Accepted:

26.10.2023

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