Effect of comorbidity on quality of life of patients with epilepsy

Close metadata

Recommended articles:

Targeting NMDAR/AMPAR: a promising pharmacotherapeutic approach for depressive disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5):22-30

Posttraumatic stress disorder clinical guidelines and treatment standards: focus on the symptoms of the psychophysiological arousal. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5):58-68

Asthenia in young patients and possibilities for its correction. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5):133-137

Management of patients with insomnia and polymorbidity. A draft of the clinical guidelines. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5-2):39-52

Trait and state anxiety, symptoms of insomnia and their influence on daytime functioning in adolescent girls. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5-2):66-71

Assessment of patient satisfaction during therapeutic plasmapheresis. Russian Journal of Preventive Medicine. 2024;(5):46-52

Life quality of universities’ students during COVID-19 pandemic. Russian Journal of Preventive Medicine. 2024;(5):92-96

Comorbid disorders and risk factors for neiropathic pain in distal diabetic polyneuropathy. Russian Journal of Pain. 2024;(2):41-48

Exploring the feasibility of peroral endoscopic myotomy for stage IV esophageal achalasia patients. Russian Journal of Evidence-Based Gastroenterology. 2024;(2):5-13

Oral sedation in pediatric outpatient dentistry. Stomatology. 2024;(3):42-49

Authors have studied 484 patients, aged from 35 to 55 years (mean - 41.0±1.4 years), in the early stages of cerebrovascular insufficiency. Computed morphodensitometry of erythrocytes, the study of their deformation and aggregation capacity have been used. It have studied the subpopulation content of erythrocytes and determined their morphometric parameters. The morphodensitometric changes in erythrocytes were correlated with disturbances of their functions (aggregation properties, deformation, gas transfer ability) that had the most impact on the hemodynamics of the microcirculation stream. Clinical and laboratory studies revealed that the morphofunctional changes in erythrocytes appeared earlier and played a key pathogenetic role in the formation and progression of cerebral ischemic hypoxia.

Keywords:

epilepsy

comorbidity

depression

anxiety

sleep disorders

quality of life

Authors:

Melikian E.G.

Pirogov National Medico-Surgery Center

Gekht A.B.

Kafedra nevrologii i neĭrokhirurgii lechebnogo fakul'teta Rossiĭskogo natsional'nogo issledovatel'skogo universiteta im. N.I. Pirogova

SPIN RSCI: 7691-3288
Scopus AuthorID: 7003326363
ResearcherID: Y-6725-2018
ORCID: 0000-0002-1170-6127

List of references:

Avakyan G.G., Badalyan O.L., Burd S.G. i dr. Depressiya i epilepsiya: dve storony odnoi medali. Rus med zhurn 2008; 12: 1653-1657.
Azimova Yu.E., Tabeeva G.R. Migren' i epilepsiya. Paroksizmal'nye rasstroistva i epilepsiya 2009; 1: 21-25
Gekht A.B., Melikyan E.G. Komorbidnost' u bol'nykh epilepsiei. Rossiiskii natsional'nyi kongress "Chelovek i lekarstvo", 15-i: Trudy. M 2008; 2: 285-290.
Zenkov L.R. Lechenie epilepsii: spravochnoe rukovodstvo dlya vrachei. M: R-Vrach 2001; 232.
Karlov V.A. Osobennosti razvitiya i techeniya epilepsii u zhenshchin. Rossiiskii natsional'nyi kongress "Chelovek i lekarstvo", 16-i: Trudy. M 2009; 1: 79-95.
Karlov V.A. Epilepsiya kak klinicheskaya i neirofiziologicheskaya problema. Zhurn nevrol i psikhiat 2000; 100: 9: 7-15.
Kuz'minova M.V. Osobennosti kachestva zhizni i sotsial'nogo funktsionirovaniya bol'nykh epilepsiei. Med vestn 2008; 38: 465.
Khabibova A.O. Kachestvo zhizni bol'nykh partsial'noi epilepsiei vzroslykh: Dis. … kand. med. nauk. M 1998.
Alanis-Guevara I., Pena E., Corona T. et al. Sleep disturbancies, socioeconomic status, and seizure control as main predictors of quality of life in epilepsy. Epilepsy Behav 2005; 7: 3: 481-485.
Al Marzooqi S.M., Baker G.A., Reilly J., Salmon P. The perceived health status of people with psychologically derived nonepileptic attack disorder and epilepsy: a comparative study. Seizure 2004; 13: 2: 71-75.
Andelman F., Field I., Neufeld M.Y. Quality of life self-assessment as a function of lateralization of lesion in candidates for epilepsy surgery. Epilepsia 2001; 42: 4: 549-555.
Au A., Li P., Chan J. et al. Predicting quality of life in Hong Kong Chinese adults with epilepsy. Epilepsy Behav 2002; 3: 4: 350-357.
Austin J.K., Shafer P.O., Deering J.B. Epilepsy familiarity, knowledge and perception of stigma: report from a survey of adolescents in the general population. Epilepsy Behav 2002; 3: 4: 368-375.
Aydemir N., Ozkara C., Canbeyli R. et al. Changes in quality of life and self-perspective related to surgery in patients with temporal lobe epilepsy. Epilepsy Behav 2004; 5: 5: 735-742.
Babu C.S., Satishchandra P., Sinha S. et al. Co-morbidities in people living with epilepsy: hospital based case-control study from a resource-poor setting. Epilepsy Res 2009; 86: 2-3: 146-152.
Baker G.A., Jacoby A., Buck D. et al. The quality of life of older people with epilepsy: findings from a community study. Seizure 2001; 10: 2: 92-99.
Baumeister H., Balke K., Harter M. Psychiatric and somatic comorbidities are negatively associated with quality of life in physically ill patients. J Clin Epidemiol 2005; 58: 11: 1090-1100.
Bazil C.W. Epilepsy and sleep disturbance. Epilepsy Behav 2003; 4: Suppl 2: 39-45.
Beyenburg S., Mitchell A.J., Schmidt D. et al. Anxiety in patients with epilepsy: Systematic review and suggestions for clinical management. Epilepsy Behav 2005; 7: 2: 161-171.
Boro A., Haut S. Medical comorbidities in the treatment of epilepsy. Epilepsy Behav 2003; 4: Suppl 2: 2-12.
Boylan L.S., Flint L.A., Labovitz D.L. et al. Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy. Neurology 2004; 62: 2: 258-261.
Brodtkorb E., Mula M. Optimizing therapy of seizures in adult patients with psychiatric comorbidity. Neurology 2006; 67: Suppl 4: 39-44.
Camfield C., Breau L., Camfield P. Impact of pediatric epilepsy on the family: a new scale for clinical and research use. Epilepsia 2001; 42: 1: 104-112.
Canuet L., Ishii R., Iwase M. et al. Factors associated with impaired quality of life in younger and older adults with epilepsy. Epilepsy Res 2009; 83: 1: 58-65.
Cascino G.D. Improving quality of life with epilepsy surgery: the seizure outcome is the key to success. Neurology 2007; 68: 23: 1967-1968.
Choi-Kwon S., Chung C., Kim H. et al. Factors affecting quality of life in patients with epilepsy in Seoul, South Kore. Acta Neurol Scand 2003; 108: 6: 428-434.
Cramer J.A. Mood disorders are linked to health-related quality of life in epilepsy. Epilepsy Behav 2002; 3: 6: 491-492.
Cramer J.A., Blum D., Fanning K. et al. The impact of comorbid depression on health resource utilization in a community sample of people with epilepsy. Epilepsy Behav 2004; 5: 3: 337-342.
Cramer J.A., Blum D., Reed M., Fanning K. The influence of comorbid depression on seizure severity. Epilepsia 2003; 44: 12: 1578-1584.
Cramer J.A., Brandenburg N., Xu X. Differentiating anxiety and depression symptoms in patients with partial epilepsy. Epilepsy Behav 2005; 6: 4: 563-569.
Cramer J.A., Perrine K., Cramer J.A. et al. Development and cross-cultural translations of a 31-item quality of life in epilepsy inventory. Epilepsia 1998; 39: 1: 81-88.
da Silva T.I., Ciconelli R.M., Alonso N.B. et al. Validity and reliability of the Portuguese version of the quality of life in epilepsy inventory (QOLIE-31) for Brazil. Epilepsy Behav 2007; 10: 2: 234-241.
Devinsky O. Psychiatric comorbidity in patients with epilepsy: implications for diagnosis and treatment. Epilepsy Behav 2003; 4: Suppl 4: 2-10.
de Weerd A., de Haas S., Otte A. et al. Subjective sleep disturbance in patients with partial epilepsy: a questionnaire-based study on prevalence and impact on quality of life. Epilepsia 2004; 45: 11: 1397-1404.
Dudra-Jastrzebska M., Andres-Mach M.M., Luszczki J.J. et al. Mood disorders in patients with epilepsy. Pharmacological Rep 2007; 59: 4: 369-378.
Elliott J.O., Lu B., Shneker B., Charyton C. et al. Comorbidity, health screening, and quality of life among persons with a history of epilepsy. Epilepsy Behav 2009; 14: 1: 125-129.
Ettinger A.B., Reed M., Cramer J. Depression and comorbidity in community-based patients with epilepsy or asthma. Neurology 2004; 63: 6: 1008-1014.
Fawley J.A., Pouliot W.A., Dudek F.E. Epilepsy and reproductive disorders: the role of the gonadotropin-releasing hormone network. Epilepsy Behav 2006; 8: 3: 477-482.
Friedman D.E., Kung D.H., Laowattana S. et al. Identifying depression in epilepsy in a busy clinical setting is enhanced with systematic screening. Seizure 2009; 18: 6: 429-433.
Gaitatzis A., Carroll K., Majeed A. et al. The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia 2004; 45: 12: 1613-1622.
Gilliam F.G., Kanner A.M. Treatment of depressive disorders in epilepsy patients. Epilepsy Behav 2002; 3: Suppl 5: 2-9.
Gilliam F.G., Santos J., Vahle V. et al. Depression in epilepsy: ignoring clinical expression of neuronal network dysfunction. Epilepsia 2004; 45: Suppl 2: 28-33.
Gilliam F.G., Santos J., Vahle V. et al. Depression in epilepsy: ignoring clinical expression of neuronal network dysfunction. Epilepsia 2004; 45: Suppl 2: 28-33.
Goldstein M.A., Harden C.L. Epilepsy and anxiety. Epilepsy Behav 2003; 4: Suppl 4: 20-25.
Harris E.C., Barraclough B. Suicide as an outcome for mental disorders. A meta-analysis. Br J Psychiat 1997; 170: 205-228.
Hermann B.P. The evolution of health-related quality of life assessment in epilepsy. Qual Life Res 1995; 4: 2: 87-100.
Hermann B.P., Seidenberg M., Bell B. Psychiatric comorbidity in chronic epilepsy: identification, consequences, and treatment of major depression. Epilepsia 2000; 41: Suppl 2: 31-41.
Hesdorffer D.C., Hauser W.A., Annegers J.F. et al. Major depression is a risk factor for seizures in older adults. Ann Neurol 2000; 47: 2: 246-249.
Hoare P., Kerley S. Psychosocial adjustment of children with chronic epilepsy and their families. Dev Med Child Neurol 1991; 33: 3: 201-211.
Jenssen S., Gracely E., Mahmood T. et al. Subjective somnolence relates mainly to depression among patients in a tertiary care epilepsy center. Epilepsy Behav 2006; 9: 4: 632-635.
Jones R.M., Butler J.A., Thomas V.A. et al. Adherence to treatment in patients with epilepsy: association with seizure control and illness beliefs. Seizure 2006; 15: 7: 504-508.
Johnson E.K., Jones J.E., Seidenberf M. et al. The relative impact of anxiety, depression, and clinical seizure features on health-related quality of life in epilepsy. Epilepsia 2004; 45: 5: 544-550.
Kanner A.M. Psychiatric issues in epilepsy: the complex relation of mood, anxiety disorders, and epilepsy. Epilepsy Behav 2009; 15: 1: 83-87.
Kanner A.M. Suicidality and epilepsy: a complex relationship that remains misunderstood and underestimated. Epilepsy Curr 2009; 9: 4: 96-97.
Kanner A.M., Palac S. Depression in epilepsy: a common but often unrecognized comorbid malady. Epilepsy Behav 2000; 1: 1: 37-51.
Kanner A.M., Soto A., Gross-Kanner H. Prevalence and clinical characteristics of postictal psychiatric symptoms in partial epilepsy. Neurology 2004: 62: 5: 708-713.
Kemp S., Morley S., Anderson E. Coping with epilepsy: do illness representations play a role. Br J Clin Psychol 1999; 38: Pt 1: 43-58.
Kimiskidis V.K., Triantafyllou N.I., Kararizou E. et al. Depression and anxiety in epilepsy: the association with demographic and seizure - related variables. Annals Gen Psychiat 2007; 6: 28.
Kobau R., Gilliam F., Thurman D.J. Prevalence of epilepsy and health status of adults with epilepsy in Georgia and Tennessee: Behavioral Risk Factor Surveillance System, 2002. Epilepsy Behav 2004; 5: 3: 358-366.
Lado F., Spiegel R., Masur J.H. et al. Value of routine screening for bone demineralization in an urban population of patients with epilepsy. Epilepsy Res 2008; 78: 2-3: 155-160.
Lambert M.V., Robertson M.M. Depression in epilepsy: etiology, phenomenology and treatment. Epilepsia 1999; 40: Suppl 10: 21-47.
Leidy N.K., Elixhauser A., Vickrey B. et al. Seizure frequency and the health-related quality of life of adults with epilepsy. Neurology 1999; 53: 1: 162-166.
Lehrner J., Kalchmayr R., Serles W. et al. Health-related quality of life (HRQOL), activity of daily living (ADL) and depressive mood disorder in temporal lobe epilepsy patients. Seizure 1999; 8: 2: 88-92.
Malmgren K., Sullivan M., Ekstedt G. et al. Health-related quality of life after epilepsy surgery: a Swedish multicenter study. Epilepsia 1997; 38: 7: 830-838.
Mattson P., Tibblin B., Kihlgreen M. et al. A prospective study of anxiety with respect to seizure outcome after epilepsy surgery. Seizure 2005; 14: 1: 40-45.
Mohanraj R., Brodie M.J. Predicting outcomes in newly diagnosed epilepsy. Epilepsia 2003; 44: Suppl 9: 15.
Nikoobakht M., Motamedi M., Orandi A. et al. Sexual dysfunction in epileptic men. Urol J 2007; 4: 2: 111-117.
Perrine K., Hermann B.P., Meador K.J. et al. The relationship of neuropsychological functioning to quality of life in epilepsy. Arch Neurol 1995; 52: 10: 997-1003.
Pompili M., Vanacore N., Macone S. et al. Depression, hopelessness and suicide risk among patients suffering from epilepsy. Ann Ist Super Sanita 2007; 43: 4: 425-429.
Pulsipher D.T., Seidenberg M., Jones J. et al. Quality of life and comorbid medical and psychiatric conditions in temporal lobe epilepsy. Epilepsy Behav 2006; 9: 3: 511-514.
Reuber M., Andersen B., Elger C.E. et al. Depression and anxiety before and after temporal lobe epilepsy surgery. Seizure 2005; 13: 2: 129-135.
Sherman E.M.S., Slick D.J., Connolly M.B. et al. ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy. Epilepsia 2007; 48: 6: 1083-1091.
Sheth R.D., Harden C.L. Screening for bone health in epilepsy. Epilepsia 2007; 48: Suppl 9: 39-41.
Strine T.W., Kobau R., Chapman D.R. et al. Psychological distress, comorbidities, and health behaviors among US adults with seizures. Epilepsia 2005; 46: 7: 1133-1139.
Souverein P.C., Webl D.J., Weil J.G. et al. Use of antiepileptic drugs and risk of fractures: case-control study among patients with epilepsy. Neurology 2006; 66: 9: 1318-1324.
Szaflarski J.P., Szaflarski M. Seizure disorders, depression, and health-related quality of life. Epilepsy Behav 2004; 5: 1: 50-57.
Telez-Zenteno J.F., Dhar R., Hernandez-Ronquillo L. et al. Long-term outcomes in epilepsy surgery: antiepileptic drugs, mortality, cognitive and psychosocial aspects. Brain 2007; 130: Pt 2: 334-345.
Testa S.M., Scheff B.K., Szaflarski J.P. et al. Mood, personality, and health-related quality of life in epileptic and psychogenic seizure disorders. Epilepsia 2007; 48: 5: 973-982.
Thompson P.J., Upton D. The impact of chronic epilepsy on the family. Seizure 1992; 1: 1: 43-48.
Tracy J.I., Dechant V., Sperling M.R. et al. The association of mood with quality of life ratings in epilepsy. Neurology 2007; 68: 14: 1101-1117.
van Elst L.T., Trimble M.R., Boylan L.S. et al. Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy. Neurology 2004; 63: 5: 942-943.
Vasquez B., Devinsky O. Epilepsy and anxiety. Epilepsy Behav 2003; 4: Suppl 4: 20-25.
Vaughn B.V., D'Cruz O.F. Sleep and epilepsy. Semin Neurol 2004; 24: 3: 301-313.
Wiebe S., Hesdorffer D.C. Epilepsy: being ill in more ways than one. Epilepsy Curr 2007; 7: 6: 145-148.
Williams J., Steel C., Sharp G.B. et al. Anxiety in children with epilepsy. Epilepsy Behav 2003; 4: 6: 729-732.
Xu X., Brandenburg N.A., McDennoth A.M. Sleep disturbances reported by refractory partial-onset epilepsy patients receiving polytherapy. Epilepsia 2006; 47: 7: 1176-1183.
Yuen A.W., Thompson B.J., Flugel D. et al. Mortality and morbidity rates are increased in people with epilepsy: is stress part of the equation Epilepsy Behav 2007; 10: 1: 1-7.

Close metadata