Molecular-genetic study of early-onset schizophrenia

Pakhomova S.A.

Saratovskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Korovaĭtseva G.I.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Monchakovkaia M.Iu.

Moskovskaia gorodskaia klinicheskaia psikhiatricheskaia bolnitsa #1 im. A.N. Alekseeva

Vilianov V.B.

Saratovskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Frolova L.P.

Moskovskaia gorodskaia klinicheskaia psikhiatricheskaia bolnitsa #1 im. A.N. Alekseeva

Kasparov S.V.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Kolesnichenko E.V.

Saratovskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Molecular-genetic study of early-onset schizophrenia

Authors:

Pakhomova S.A., Korovaĭtseva G.I., Monchakovkaia M.Iu., Vilianov V.B., Frolova L.P., Kasparov S.V., Kolesnichenko E.V., Golimbet V.E.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(2): 66‑69

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To cite this article:

Pakhomova SA, Korovaĭtseva GI, Monchakovkaia MIu, et al. . Molecular-genetic study of early-onset schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(2):66‑69. (In Russ.)

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Schizophrenia with early onset is a relatively rear form of the disease which characterized by severe chronic course and poor outcome. In the present paper, we studied several genes possibly involved in the pathogenesis of this form. These are genes for brain-derived neurotrophic factor (Val66Met polymorphism), serotonin transporter (5-HTTLPR), serotonin receptor type 2A (T102C) and dopamine receptor D2 (Taq1A). Sixty-five patients (age at onset before 15 years) and 111 healthy controls were included in the study. Out of all genes tested, the association was found only for the Val66Met BDNF polymorphism. Frequency of the ValVal genotype was higher in the group of patients (p=0,03; OR 2,1 CI 1,1-4,0) compared to the controls. These results were consistent with our previous study which was carried out on the sample of schizophrenic patients with later age of disease onset. In this study, the frequency of the ValVal genotype was higher only in the group of patients with chronic schizophrenia compared to the controls. It is concluded that the ValVal BDNF genotype may be considered as a marker of schizophrenia with more severe course.

Keywords:

schizophrenia

early onset

genes

brain-derived neurotrophic factor

Authors:

Pakhomova S.A.

Saratovskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Korovaĭtseva G.I.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Monchakovkaia M.Iu.

Moskovskaia gorodskaia klinicheskaia psikhiatricheskaia bolnitsa #1 im. A.N. Alekseeva

Vilianov V.B.

Saratovskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Frolova L.P.

Moskovskaia gorodskaia klinicheskaia psikhiatricheskaia bolnitsa #1 im. A.N. Alekseeva

Kasparov S.V.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Kolesnichenko E.V.

Saratovskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

List of references:

Golimbet V.E., Mityushina N.G., Shcherbatykh T.V. i dr. Molekulyarno-geneticheskii polimorfizm nekotorykh genov-kandidatov psikhicheskikh zabolevanii u bol'nykh shizofreniei s rannim nachalom manifestatsii. Zhurn nevrol i psikhiat 2001; 101: 4: 48-50.
Golimbet V.E., Aksenova M.G., Nosikov V.V. i dr. Analiz stsepleniya lokusov Taq1A i Taq1B s shizofreniei u bol'nykh i ikh siblingov. Zhurn nevrol i psikhiat 2002; 102: 4: 43-44.
Golimbet V.E., Korovaitseva G.I., Abramova L.I. i dr. Svyaz' polimorfnogo markera VAL66MET gena neirotroficheskogo faktora golovnogo mozga s shizofreniei v russkoi populyatsii. Mol biol 2008; 42: 4: 599-603.
Shcherbatykh T.V., Golimbet V.E., Orlova V.A. i dr. Polimorfizm v gene serotoninovogo transportera cheloveka pri endogennykh psikhozakh. Genetika 2000; 36: 12: 1712-1715.
Abdolmaleky H.M., Faraone S.V., Glatt S.J. et al. Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. Schizophr Res 2004; 67: 1: 53-62.
Addington A.M., Gornick M., Sporn A.L. et al. Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified. Biol Psychiat 2004; 55: 10: 976-980.
Chao H.M., Kao H.T., Porton B. BDNF Val66Met variant and age of onset in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2008; 147B: 4: 505-506.
Dubertret C., Gouya L., Hanoun N. et al. The 3 region of the DRD2 gene is involved in genetic susceptibility to schizophrenia Schizophr Res 2004; 67: 1: 75-85.
Goldberg T.E., Kotov R., Lee A.T. et al. The serotonin transporter gene and disease modification in psychosis: evidence for systematic differences in allelic directionality at the 5-HTTLPR locus. Schizophr Res 2009; 111: 1-3: 103-108.
Golimbet V.E., Lavrushina O.M., Kaleda V.G. et al. Supportive evidence for the association between the T102C 5-HTR2A gene polymorphism and schizophrenia: a large-scale case-control and family-based study. Eur Psychiat 2007; 22: 3: 167-170.
Gornick M.C., Addington A.M., Sporn A. et al. Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS). J Autism Dev Disord 2005; 35: 6: 831-838.
Gourion D., Goldberger C., Leroy S. et al. Age at onset of schizophrenia: interaction between brain-derived neurotrophic factor and dopamine D3 receptor gene variants. Neuroreport 2005; 16: 12: 1407-1410.
Hernandez I., Sokolov B.P. Abnormalities in 5-HT2A receptor mRNA expression in frontal cortex of chronic elderly schizophrenics with varying histories of neuroleptic treatment. J Neurosci Res 2000; 59: 2: 218-225.
Iwata Y., Matsumoto H., Minabe Y. et al. Early-onset schizophrenia and dopamine-related gene polymorphism. Am J Med Genet B Neuropsychiatr Genet 2003; 116B: 1: 23-26.
Lesch K.P., Bengel D., Heils A. et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531.
Maziade M., Martinez M., Rodrigue C. et al. Childhood/early adolescence-onset and adult-onset schizophrenia. Heterogeneity at the dopamine D3 receptor gene. Br J Psychiat 1997; 170: 27-30.
Naoe Y., Shinkai T., Hori H. et al. No association between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and schizophrenia in Asian populations: Evidence from a case-control study and meta-analysis. Neurosci Lett 2007; 415: 2: 108-112.
Nicolson R., Lenane M., Hamburger S.D. et al. Lessons from childhood-onset schizophrenia. Brain Res Brain Res Rev 2000; 31: 2-3: 147-156.
Numata S., Ueno S., Iga J. et al. Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms. Neurosci Lett 2006; 401: 1-2: 1-5.
Sekizawa T., Iwata Y., Nakamura K. et al. Childhood-onset schizophrenia and tryptophan hydroxylase gene polymorphism. Am J Med Genet B Neuropsychiatr Genet 2005; 136B: 1: 106.
Weickert C.S., Hyde T.M., Lipska B.K. et al. Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia. Mol Psychiat 2003; 8: 6: 592-610.

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