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Moritz A.A.

Saint Petersburg University

Shoshina I.I.

Saint Petersburg University

Lyapunov I.S.

Prokhorov General Physics Institute of the Russian Academy of Sciences

Ivanov M.V.

V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology

Lyapunov S.I.

Prokhorov General Physics Institute of the Russian Academy of Sciences

Search for neurophysiological markers of schizophrenia spectrum disorders: ocular microtremor and contrast sensitivity

Authors:

Moritz A.A., Shoshina I.I., Lyapunov I.S., Ivanov M.V., Lyapunov S.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(12): 228‑236

DOI: 10.17116/jnevro2025125121228

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Table of contents

SEARCH FOR NEUROPHYSIOLOGICAL MARKERS OF SCHIZOPHRENIA SPECTRUM DISORDERS: OCULAR MICROTREMOR AND CONTRAST SENSITIVITY
SEARCH FOR NEUROPHYSIOLOGICAL MARKERS OF SCHIZOPHRENIA SPECTRUM DISORDERS: OCULAR MICROTREMOR AND CONTRAST SENSITIVITY

To cite this article:

Moritz AA, Shoshina II, Lyapunov IS, Ivanov MV, Lyapunov SI. Search for neurophysiological markers of schizophrenia spectrum disorders: ocular microtremor and contrast sensitivity. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(12):228‑236. (In Russ.)
https://doi.org/10.17116/jnevro2025125121228

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate ocular microtremor (OMT) and contrast sensitivity (CS) as potential neurophysiological markers of schizophrenia spectrum disorders (SSD).

MATERIAL AND METHODS

The study included 85 patients diagnosed with paranoid schizophrenia (F20.0), schizotypal (F21), and schizoaffective disorder (F25.X), as well as 29 healthy volunteers. The CS assessment was performed using an adaptive staircase procedure, and the OMT recording was conducted via video recording. Psychometric methods included the PANSS (Positive and Negative Syndrome Scale) and the Simpson-Angus Scale (SAS) for extrapyramidal symptoms.

RESULTS

Patients with SSD showed a decrease in CS at spatial frequencies of 1.0 and 10 cycles/deg, as well as a decrease in OMT frequency and an increase in OMT amplitude, compared with healthy subjects (p<0.05). These differences persisted even in patients without receiving long-term antipsychotics compared with healthy subjects.

CONCLUSION

Considering the data obtained, the parameters of OMT and CS seem to be promising in the context of the search for neurophysiological markers of schizophrenia.

Keywords:

schizophrenia
ocular microtremor
contrast sensitivity
schizotypal disorder
schizoaffective disorder

Authors:

Moritz A.A.

Saint Petersburg University

Shoshina I.I.

Saint Petersburg University

Lyapunov I.S.

Prokhorov General Physics Institute of the Russian Academy of Sciences

Ivanov M.V.

V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology

Lyapunov S.I.

Prokhorov General Physics Institute of the Russian Academy of Sciences

Received:

21.07.2025

Accepted:

04.09.2025

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