The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Tardov M.V.

Peoples’ Friendship University of Russia

Boldin A.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Azieva M.N.

Ear, Nose and Throat Clinic

Moiseeva V.M.

Ear, Nose and Throat Clinic

Morning headaches in patients with obstructive sleep apnea syndrome: Pathogenesis, differential diagnosis, and treatment

Authors:

Tardov M.V., Boldin A.V., Azieva M.N., Moiseeva V.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(5‑2): 92‑97

DOI: 10.17116/jnevro202512505292

Read: 1969 times

Buy for 300₽
Contact the author
Table of contents

MORNING HEADACHES IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME: PATHOGENESIS, DIFFERENTIAL DIAGNOSIS, AND TREATMENT
MORNING HEADACHES IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME: PATHOGENESIS, DIFFERENTIAL DIAGNOSIS, AND TREATMENT

To cite this article:

Tardov MV, Boldin AV, Azieva MN, Moiseeva VM. Morning headaches in patients with obstructive sleep apnea syndrome: Pathogenesis, differential diagnosis, and treatment. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(5‑2):92‑97. (In Russ.)
https://doi.org/10.17116/jnevro202512505292

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Tongue and epiglottis surgery in the treatment of obstructive sleep apnea syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):70-74
Anti-aging klotho protein. Asso­ciations with sleep patterns in obstructive sleep apnea: A pilot study. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):98-102
Obstructive sleep apnea syndrome as a predictor of atrial fibrillation. Russian Journal of Preventive Medi­cine. 2025;(1):109-114
The role of gene­tic poly­morphisms in folate meta­bolism genes in the mani­festation of migraine in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):47-52
Meniere’s disease and vestibular migraine: differential diagnostics and treatment. Russian Bulletin of Otorhinolaryngology. 2025;(1):57-63
The effe­ctiveness of laser sculpture uvulopalatoplasty in the treatment of a patient with rhonchopathy and severe obstructive sleep apnea syndrome. Clinical case. Russian Bulletin of Otorhinolaryngology. 2025;(1):75-77
Biochemical features of migraine pathogenesis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):21-26
Neurological complications invo­lving the cervical spine as a cause of adve­rse outcome in patients with rheumatoid arthritis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):133-140
Recu­rrent pain syndromes in adolescents of different ages. Russian Journal of Pain. 2025;(2):24-31
Abstract:

Sleep disorders are often associated with painful ones, especially in patients with chronic syndromes. Cephalgia occupies an important place among such algic forms as fibromyalgia, back pain, and abdominal and joint pain. Headaches and sleep disturbances may be independent, derived from a single pathogenetic factor, or their relationship may be bidirectional. This review focuses on the reciprocal relationship between headaches and sleep disorders; particular attention is paid to the morning headache variant associated with obstructive sleep apnea (OSA). Modern data on the anatomical structures and pathophysiological mechanisms common to disorders in the regulation of the sleep—wake cycle and the perception of pain impulses are presented. Possible pathogenetic processes and nuances of differential diagnosis of headaches associated with sleep apnea are discussed. Methods of treating headaches associated with sleep disorders, in particular OSA-associated cephalgia, are addressed. The effectiveness of therapy with constant positive airway pressure (CPAP therapy) and splint therapy for OSA has been shown for headaches associated with sleep apnea.

Keywords:

migraine
headache
obstructive sleep apnea syndrome
CPAP therapy
night splint
splint therapy

Authors:

Tardov M.V.

Peoples’ Friendship University of Russia

Boldin A.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Azieva M.N.

Ear, Nose and Throat Clinic

Moiseeva V.M.

Ear, Nose and Throat Clinic

Received:

10.03.2025

Accepted:

12.03.2025

Close metadata

References:

  1. Smith MT, Haythornthwaite JA. How do sleep disturbance and chronic pain inter-relate? Insights from the longitudinal and cognitive-behavioral clinical trials literature. Sleep Medicine Reviews. 2004;8:119-132.  https://doi.org/10.1016/S1087-0792(03)00044-3
  2. Aldrich MS, Chauncey JB. Are morning headaches part of obstructive sleep apnea syndrome? Arch Intern Med. 1990;150(6):1265-1267.
  3. Rains JC, Poceta JS. Sleep-related headache syndromes. Semin Neurol. 2005;25(1):69-80.  https://doi.org/10.1055/s-2005-867081
  4. Andrijauskis D, Ciauskaite J, Vaitkus A, et al. Primary Headaches and Sleep Disturbances: A Cause or a Consequence? J Oral Facial Pain Headache. 2020;34(1):61-66.  https://doi.org/10.11607/ofph.2405
  5. Rains JC, Poceta JS. Sleep and headache disorders: clinical recommendations for headache management. Headache. 2006;46(3):147-148.  https://doi.org/10.1111/j.1526-4610.2006.00567.x
  6. Ferini-Strambi L, Galbiati A, Combi R. Sleep disorder-related headaches. Neurol Sci. 2019;40(1):107-113.  https://doi.org/10.1007/s10072-019-03837-z
  7. Alberti A. Headache and sleep. Sleep Med Rev. 2006;10(6):431-437.  https://doi.org/10.1016/j.smrv.2006.03.003
  8. Ødegård SS, Engstrøm M, Sand T, et al. Associations between sleep disturbance and primary headaches: the third Nord-Trøndelag Health Study. J Headache Pain. 2010;11(3):197-206.  https://doi.org/10.1007/s10194-010-0201-8
  9. Artemenko AR, Shavlovskaja OA, Osipova VV, et al. Sleep-related headaches: clinical features and treatment approaches. L.O. Badalyan Neurological Journal. 2020;1(1):35-46. (In Russ.). https://doi.org/10.17816/2686-8997-2020-1-01-35-46
  10. Singh NN, Sahota P. Sleep-related headache and its management. Curr Treat Options Neurol. 2013;15(6):704-722.  https://doi.org/10.1007/s11940-013-0258-1
  11. DodickDW, ErossEJ, Parish JM, et al. Clinical, anatomical, and physiologic relationship between sleep and headache. Headache. 2003;43(3):282-292.  https://doi.org/10.1046/j.1526-4610.2003.03055.x
  12. Błaszczyk B, Martynowicz H, Więckiewicz M, et al. Prevalence of headaches and their relationship with obstructive sleep apnea (OSA) — Systematic review and meta-analysis. Sleep Med Rev. 2024;73:101889. https://doi.org/10.1016/j.smrv.2023.101889
  13. Loh NK, Dinner DS, Foldvary N, et al. Do patients with obstructive sleep apnea wake up with headaches? Arch Intern Med. 1999;159(15):1765-1768. https://doi.org/10.1001/archinte.159.15.1765
  14. Rains JC, Davis RE, Smitherman TA. Tension-type headache and sleep. Curr Neurol Neurosci Rep. 2015;15(2):520.  https://doi.org/10.1007/s11910-014-0520-2
  15. Alberti A, Mazzotta G, Gallinella E, et al. Headache characteristics in obstructive sleep apnea syndrome and insomnia. Acta Neurol Scand. 2005;111(5):309-316.  https://doi.org/10.1111/j.1600-0404.2005.00372.x
  16. Kristiansen HA, Kværner KJ, Akre H, et al. Sleep apnoea headache in the general population. Cephalalgia. 2012;32(6):45145-45148. https://doi.org/10.1177/0333102411431900
  17. Russell MB, Kristiansen HA, Kværner KJ. Headache in sleep apnea syndrome: epidemiology and pathophysiology. Cephalalgia. 2014;34(10):752-755.  https://doi.org/10.1177/0333102414538551
  18. Spałka J, Kędzia K, Kuczyński W, et al. Morning Headache as an Obstructive Sleep Apnea-Related Symptom among Sleep Clinic Patients-A Cross-Section Analysis. Brain Sci. 2020;10(1):57.  https://doi.org/10.3390/brainsci10010057
  19. Kovalzon VM. Functional neurochemistry of sleep—waking cycle in pathogenesis of neurological diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(4-2):5-11. (In Russ.). https://doi.org/10.17116/jnevro2017117425-11
  20. Brennan KC, Charles A. Sleep and headache. Semin Neurol. 2009;29(4):406-418.  https://doi.org/10.1055/s-0029-1237113
  21. Rains JC, Poceta JS. Sleep-related headaches. Neurol Clin. 2012;30(4):1285 1298. https://doi.org/10.1016/j.ncl.2012.08.014
  22. Roehrs T, Hyde M, Blaisdell B, et al. Sleep loss and REM sleep loss are hyperalgesic. Sleep. 2006;29(2):145-151.  https://doi.org/10.1093/sleep/29.2.145
  23. Smith MT, Edwards RR, McCann UD, et al. The effects of sleep deprivation on pain inhibition and spontaneous pain in women. Sleep. 2007;30(4):494-505.  https://doi.org/10.1093/sleep/30.4.494
  24. Edvinsson L, Uddman R. Neurobiology in primary headaches. Brain Res Rev. 2005;48(3):438-456.  https://doi.org/10.1016/j.brainresrev.2004.09.007
  25. Bruce BB, Kedar S, Van Stavern GP, et al. Idiopathic intracranial hypertension in men. Neurology. 2009;72(4):304-309.  https://doi.org/10.1212/01.wnl.0000333254.84120.f5
  26. Mitsikostas DD, Vikelis M, Viskos A. Refractory chronic headache associated with obstructive sleep apnoea syndrome. Cephalalgia. 2008;28(2):139-143.  https://doi.org/10.1111/j.1468-2982.2007.01473.x
  27. Kristiansen HA, Kværner KJ, Akre H, Øverland B, Sandvik L, Russell MB. Sleep apnoea headache in the general population. Cephalalgia. 2012;32(6):451-458.  https://doi.org/10.1177/0333102411431900
  28. Russell MB, Kristiansen KA, Kværner KJ. Headache in sleep apnea syndrome: Epidemiology and pathophysiology. Cephalalgia. 2014;34:752-755.  https://doi.org/10.1177/0333102414538551
  29. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211.  https://doi.org/10.1177/0333102417738202
  30. Maksjukova EV, Osipova VV, Tabeeva GR. Gipnicheskaja golovnaja bol’: obzor literatury, opisanie sluchaja, novye podhody k terapii. Russian Journal of Pain. 2011;1:26-31. (In Russ.).
  31. Barloese M. Current Understanding of the Chronobiology of Cluster Headache and the Role of Sleep in Its Management. Nat Sci Sleep. 2021;11(13):153-162.  https://doi.org/10.2147/NSS.S278088
  32. Kiely JL, Murphy M, McNicholas WT. Subjective efficacy of nasal CPAP therapy in obstructive sleep apnoea syndrome: a prospective controlled study. Eur Respir J. 1999;13(5):1086-1090. https://doi.org/10.1034/j.1399-3003.1999.13e24.x
  33. Goksan B, Gunduz A, Karadeniz D, et al. Morning headache in sleep apnoea: clinical and polysomnographic evaluation and response to nasal continuous positive airway pressure. Cephalalgia. 2009;29(6):635-641.  https://doi.org/10.1111/j.1468-2982.2008.01781.x
  34. Kallweit U, Hidalgo H, Uhl V, et al. Continuous positive airway pressure therapy is effective for migraines in sleep apnea syndrome. Neurology. 2011;76(13):1189-1191. https://doi.org/10.1212/WNL.0b013e318212aad0
  35. Johnson KG, Ziemba AM, Garb JL. Improvement in headaches with continuous positive airway pressure for obstructive sleep apnea: a retrospective analysis. Headache. 2013;53(2):333-343.  https://doi.org/10.1111/j.1526-4610.2012.02251.x
  36. Seo MY, Lee MK, Han MS, et al. Improvement of morning headache in adults with obstructive sleep apnea after positive airway pressure therapy. Sci Rep. 2023;13(1):14620. https://doi.org/10.1038/s41598-023-34896-0
  37. Park JW, Mehta S, Fastlicht S, et al. Changes in headache characteristics with oral appliance treatment for obstructive sleep apnea. Sci Rep. 2021;11(1):2568. https://doi.org/10.1038/s41598-021-82041-6
  38. Franco L, Rompre PH, de Grandmont P, et al. A mandibular advancement appliance reduces pain and rhythmic masticatory muscle activity in patients with morning headache. J Orofac Pain. 2011;25(3):240-249. 
  39. Ishiyama H, Liu S, Nishiyama A, et al. Morning headache caused by obstructive sleep apnea misdiagnosed as temporomandibular disorders-related headache: A case report. J Prosthodont Res. 2024;69(2):303-307.  https://doi.org/10.2186/jpr.JPR_D_24_00050
  40. Kirsch DB. Obstructive Sleep Apnea. Continuum (Minneap Minn). 2020;26(4):908-928.  https://doi.org/10.1212/CON.0000000000000885
  41. Madaeva IM, Kurashova NA, Semenova NV, et al. Obstructive sleep apnea syndrome: association of serum melatonin, increased daytime sleepiness, and intermitting night hypoxemia. Pul’monologija. 2021;31(6):768-775. (In Russ.). https://doi.org/10.18093/0869-0189-2021-31-6-768-775
  42. Biondi DM. Headaches and their relationship to sleep. Dent Clin North Am. 2001;45(4):685-700. 
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.