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Kotov S.V.

Vladimirsky Moscow Regional Clinical Research Institute

Shcherbakova M.M.

Vladimirskiy Moscow Regional Research Clinical Institute

Tonya G.T.

M.F. Vladimirsky Moscow Regional Scientific Research Clinical Institute

Stepanova E.A.

M.F. Vladimirsky Moscow Regional Clinical Research Institute

Isakova E.V.

Vladimirsky Moscow Regional Research and Clinical Institute

Zenina V.A.

Vladimirskiy Moscow Regional Research Clinical Institute;
Ramenskoye City Hospital

Primary progressive aphasia in the neurologist practice

Authors:

Kotov S.V., Shcherbakova M.M., Tonya G.T., Stepanova E.A., Isakova E.V., Zenina V.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(4‑2): 61‑66

DOI: 10.17116/jnevro202512504261

Read: 1309 times

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Table of contents

PRIMARY PROGRESSIVE APHASIA IN THE NEUROLOGIST PRACTICE
PRIMARY PROGRESSIVE APHASIA IN THE NEUROLOGIST PRACTICE

To cite this article:

Kotov SV, Shcherbakova MM, Tonya GT, Stepanova EA, Isakova EV, Zenina VA. Primary progressive aphasia in the neurologist practice. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(4‑2):61‑66. (In Russ.)
https://doi.org/10.17116/jnevro202512504261

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The article presents data on the epidemiology of stroke and dementia in the Moscow region of the Russian Federation, Western Europe, and the United States. A brief review of the literature on the problem of primary progressive aphasia (PPA) is provided, and the criteria for diagnosis and the main variants of the disease are described. Two clinical cases are presented: a patient with an agrammatic form of PPA and a patient with post-stroke aphasia. The findings of routine MRI, functional MRI with a speech paradigm and diffusion tensor imaging with tractography are shown, and the main differences in the presentation and the MRI findings in patients with similar clinical presentation of motor aphasia caused by the stroke-related neurodegenerative process are analyzed. Additional tests are provided for early detection of the agrammatical form of PPA.

Keywords:

aphasia
primary progressive aphasia
frontotemporal dementia
stroke
functional MRI
tractography

Authors:

Kotov S.V.

Vladimirsky Moscow Regional Clinical Research Institute

Shcherbakova M.M.

Vladimirskiy Moscow Regional Research Clinical Institute

Tonya G.T.

M.F. Vladimirsky Moscow Regional Scientific Research Clinical Institute

Stepanova E.A.

M.F. Vladimirsky Moscow Regional Clinical Research Institute

Isakova E.V.

Vladimirsky Moscow Regional Research and Clinical Institute

Zenina V.A.

Vladimirskiy Moscow Regional Research Clinical Institute;
Ramenskoye City Hospital

Received:

13.01.2025

Accepted:

29.01.2025

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References:

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  2. 2024 Alzheimer’s disease facts and figures. Alzheimers Dement. 2024;20(5):3708-3821. https://doi.org/10.1002/alz.13809
  3. Mikhailov VA, Kotsiubinskaya YuV, Safonova NYu, et al. Primary progressive aphasia. Nevrologiya, Neiropsikhiatriya, Psikhosomatika=Neurology, Neuropsychiatry, Psychosomatics. 2019;11(1):4-11. (In Russ.). https://doi.org/10.14412/2074-2711-2019-1-4-11
  4. Akhmadullina DR, Fedotova EYu. Primary progressive aphasia: variants and main language domains. Annals of Clinical and Experimental Neurology. 2024;18(4):68-75. (In Russ.). https://doi.org/10.17816/ACEN.1067
  5. Khan S, Barve KH, Kumar MS. Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease. Curr Neuropharmacol. 2020;18(11):1106-1125. https://doi.org/10.2174/1570159X18666200528142429
  6. Zhang L, Pini L. A divergent pattern in functional connectivity: a transdiagnostic perspective. Neural Regen Res. 2024;19(9):1885-1886. https://doi.org/10.4103/1673-5374.390982
  7. Mesulam MM. Slowly progressive aphasia without generalized dementia. Ann Neurol. 1982;11(6):592-598.  https://doi.org/10.1002/ana.410110607
  8. Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76(11):1006-1014. https://doi.org/10.1212/WNL.0b013e31821103e6
  9. Mesulam MM, Rogalski EJ, Wieneke C, et al. Primary progressive aphasia and the evolving neurology of the language network. Nat Rev Neurol. 2014;10(10):554-569.  https://doi.org/10.1038/nrneurol.2014.159
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  11. Vasenina EE, Levin OS. Primary progressive aphasias. S.S. Korsakov Journal of Neurology and Psychiatry. 2014;114(6-2):3-12. (In Russ.).
  12. Coyle-Gilchrist IT, Dick KM, Patterson K, et al. Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes. Neurology. 2016;86(18):1736-1743. https://doi.org/10.1212/WNL.0000000000002638
  13. Hogan DB, Jetté N, Fiest KM, et al. The Prevalence and Incidence of Frontotemporal Dementia: a Systematic Review. Can J Neurol Sci. 2016;43 Suppl 1:S96-S109. https://doi.org/10.1017/cjn.2016.25
  14. Olney NT, Spina S, Miller BL. Frontotemporal Dementia. Neurol Clin. 2017;35(2):339-374.  https://doi.org/10.1016/j.ncl.2017.01.008
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