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Kovalenko E.A.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies

Makhnovich E.V.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies

Bogolepova A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Osinovskaya N.A.

Federal Center of Brain Research and Neurotechnologies

Beregov M.M.

Federal Center of Brain Research and Neurotechnologies

Features of the clinical and neuroimaging picture in patients with early-onset Alzheimer’s disease

Authors:

Kovalenko E.A., Makhnovich E.V., Bogolepova A.N., Osinovskaya N.A., Beregov M.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4‑2): 56‑63

DOI: 10.17116/jnevro202412404256

Views: 1063

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To cite this article:

Kovalenko EA, Makhnovich EV, Bogolepova AN, Osinovskaya NA, Beregov MM. Features of the clinical and neuroimaging picture in patients with early-onset Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4‑2):56‑63. (In Russ.)
https://doi.org/10.17116/jnevro202412404256

Подписка 2025 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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The most common cause of severe cognitive impairment in adults is Alzheimer’s disease (AD). Depending on the age of onset, AD is divided into early (<65 years) and late (≥65 years) forms. Early-onset AD (EOAD) is significantly less common than later-onset AD (LOAD) and accounts for only about 5—10% of cases. However, its medical and social significance, as a disease leading to loss of ability to work and legal capacity, as well as premature death in patients aged 40-64 years, is extremely high. Patients with EOAD compared with LOAD have a greater number of atypical clinical variants — 25% and 6—12.5%, respectively, which complicates the differential diagnosis of EOAD with other neurodegenerative diseases. However, the typical classical amnestic variant predominates in both EOAD and LOAD. Also, patients with EOAD have peculiarities according to neuroimaging data: when performing MRI of the brain, patients with EOAD often have more pronounced parietal atrophy and less pronounced hippocampal atrophy compared to patients with LOAD. The article pays attention to the features of the clinical and neuroimaging data in patients with EOAD; a case of a patient with EOAD is presented.

Keywords:

early-onset Alzheimer’s disease
clinical picture
brain MRI
neuroimaging
clinical case

Authors:

Kovalenko E.A.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies

Makhnovich E.V.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies

Bogolepova A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Osinovskaya N.A.

Federal Center of Brain Research and Neurotechnologies

Beregov M.M.

Federal Center of Brain Research and Neurotechnologies

Received:

18.01.2024

Accepted:

19.02.2024

List of references:

  1. Bondi MW, Edmonds EC, Salmon DP. Alzheimer’s Disease: Past, Present, and Future. J Int Neuropsychol Soc. 2017;23(9-10):818-831.  https://doi.org/10.1017/S135561771700100X
  2. Kamboh MI. Genomics and Functional Genomics of Alzheimer’s Disease. Neurotherapeutics. 2022;19(1):152-172.  https://doi.org/10.1007/s13311-021-01152-0
  3. Ayodele T, Rogaeva E, Kurup JT, et al. Early-Onset Alzheimer’s Disease: What Is Missing in Research? Curr Neurol Neurosci Rep. 2021;19;21(2):4.  https://doi.org/10.1007/s11910-020-01090-y
  4. Vogt AS, Jennings GT, Mohsen MO, et al. Alzheimer’s Disease: A Brief History of Immunotherapies Targeting Amyloid β. Int J Mol Sci. 2023;15;24(4):3895. https://doi.org/10.3390/ijms24043895
  5. Lokshina AB, Grishina DA, Obukhova AV. Early-onset Alzheimer’s disease. Neurology, Neuropsychiatry, Psychosomatics. 2022;14(2):110-116. (In Russ.). https://doi.org/10.14412/2074-2711-2022-2-110-116
  6. Barber IS, Braae A, Clement N, et al. Aruk Consortium, Morgan K. Mutation analysis of sporadic early-onset Alzheimer’s disease using the NeuroX array. Neurobiol Aging. 2017;49:215-215.  https://doi.org/10.1016/j.neurobiolaging.2016.09.008
  7. Cacace R, Sleegers K, Van Broeckhoven C. Molecular genetics of early-onset Alzheimer’s disease revisited. Alzheimers Dement. 2016;12(6):733-748.  https://doi.org/10.1016/j.jalz.2016.01.012
  8. Dai MH, Zheng H, Zeng LD, et al. The genes associated with early-onset Alzheimer’s disease. Oncotarget. 2017;15;9(19):15132-15143. https://doi.org/10.18632/oncotarget.23738
  9. Maurer K, Volk S, Gerbaldo H. Auguste D and Alzheimer’s disease. Lancet. 1997;349(9064):1546-1549. https://doi.org/10.1016/S0140-6736(96)10203-8
  10. Koberskaya NN, Kovalchuk NA. Alzheimer’s disease with an early debut. Meditsinsky Sovet. 2019; 1:10-16. Medical Council. 2019;1:10-16. (In Russ.). https://doi.org/10.21518/2079-701X-2019-1-10-16
  11. Litvinenko IV, Emelin AYu, Lobzin Yu, et al. he amyloid hypothesis of Alzheimer’s disease: past and present, hopes and disappointments. Neurology, Neuropsychiatry, Psychosomatics. 2019;11(3):4-10. (In Russ.). https://doi.org/10.14412/2074-2711-2019-3-4-10
  12. Sirkis DW, Bonham LW, Johnson TP, et al. Dissecting the clinical heterogeneity of early-onset Alzheimer’s disease. Mol Psychiatry. 2022;27(6):2674-2688. https://doi.org/10.1038/s41380-022-01531-9
  13. Lambert MA, Bickel H, Prince M, et al. Estimating the burden of early onset dementia; systematic review of disease prevalence. Eur J Neurol. 2014;21(4):563-569.  https://doi.org/10.1111/ene.12325
  14. Renvoize E, Hanson M, Dale M. Prevalence and causes of young onset dementia in an English health district. Int J Geriatr Psychiatry. 2011;26(1):106-107.  https://doi.org/10.1002/gps.2456
  15. Mendez MF. Early-onset Alzheimer disease. Neurol Clin. 2017;35(2):263-281.  https://doi.org/10.1016/j.ncl.2017.01.005
  16. Wingo TS, Lah JJ, Levey AI, et al. Autosomal recessive causes likely in early-onset Alzheimer disease. Arch Neurol. 2012;69(1):59-64.  https://doi.org/10.1001/archneurol.2011.221
  17. Jarmolowicz AI, Chen HY, Panegyres PK. The patterns of inheritance in early-onset dementia: Alzheimer’s disease and frontotemporal dementia. Am J Alzheimers Dis Other Dement. 2015;30(3):299-306.  https://doi.org/10.1177/1533317514545825
  18. Campion D, Dumanchin C, Hannequin D, et al. Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum. Am J Hum Genet. 1999;65(3):664-670.  https://doi.org/10.1086/302553
  19. Bates KA, Verdile G, Li QX, et al. Clearance mechanisms of Alzheimer’s amyloid-beta peptide: implications for therapeutic design and diagnostic tests. Mol Psychiatry. 2009;14(5):469-486.  https://doi.org/10.1038/mp.2008.96
  20. Reitz C, Rogaeva E, Beecham GW. Late-onset vs nonmendelian early-onset Alzheimer disease: A distinction without a difference? Neurol Genet. 2020;6;6(5):512.  https://doi.org/10.1212/NXG.0000000000000512
  21. Lopez-Riquelme N, Alom-Poveda J, Viciano-Morote N, et al. Apolipoprotein E epsilon4 allele and malondialdehyde level are independent risk factors for Alzheimer’s disease. SAGE Open Med. 2016;4:2050312115626731. https://doi.org/10.1177/2050312115626731
  22. Genin E, Hannequin D, Wallon D, et al. APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Mol Psychiatry. 2011;16:903-907.  https://doi.org/10.1038/mp.2011.52
  23. Nicolas G, Charbonnier C, Wallon D, et al. SORL1 rare variants: a major risk factor for familial early-onset Alzheimer’s disease. Mol Psychiatry. 2016;21(6):831-836.  https://doi.org/10.1038/mp.2015.121
  24. Verheijen J, Van den Bossche T, van der Zee J, et al. A comprehensive study of the genetic impact of rare variants in SORL1 in European early-onset Alzheimer’s disease. Acta Neuropathol. 2016;132(2):213-224.  https://doi.org/10.1007/s00401-016-1566-9
  25. Pottier C, Wallon D, Rousseau S, et al. TREM2 R47H variant as a risk factor for early-onset Alzheimer’s disease. J Alzheimers Dis JAD. 2013;35:45-59. 
  26. Jiao B, Liu H, Guo L, et al. The role of genetics in neurodegenerative dementia: a large cohort study in South China. NPJ. Genom Med. 2021;6:69.  https://doi.org/10.1038/s41525-021-00235-3
  27. Shpilyukova YuA, Protopopova AO, Abramycheva NYu, et al. Rapidly progressive dementia with early onset associated with the I143T mutation in the PSEN1 gene: a clinical case in a family from Russia.Neurology, Neuropsychiatry, Psychosomatics. 2023;15(2):63-67. (In Russ.). https://doi.org/10.14412/2074-2711-2023-2-63-67
  28. Hammers DB, Eloyan A, Taurone A, et al. LEADS Consortium. Profiling baseline performance on the Longitudinal Early-Onset Alzheimer’s Disease Study (LEADS) cohort near the midpoint of data collection. Alzheimers Dement. 2023;19(9):8-18.  https://doi.org/10.1002/alz.13399
  29. Mendez MF, Lee AS, Joshi A, et al. Nonamnestic presentations of early-onset Alzheimer’s disease. Am J Alzheimers Dis Other Demen. 2012;27:413-420.  https://doi.org/10.1177/1533317512454711
  30. Bateman RJ, Aisen PS, De Strooper B, et al. Autosomal-dominant Alzheimer’s disease: a review and proposal for the prevention of Alzheimer’s disease. Alzheimers Res Ther. 2011;3(1):1.  https://doi.org/10.1186/alzrt59
  31. Koedam EL, Lauffer V, van der Vlies AE, et al. Early-versus late-onset Alzheimer’s disease: more than age alone. J Alzheimers Dis 2010;19:1401-1408.
  32. Emelin AYu, Odinak MM, Lobzin VYu, Galaeva AA. Alzheimer’s disease — heterogenous disease. Russian Military Medical Academy Reports. 2021;40(S4):37-41. (In Russ.).
  33. Lei D, Mao C, Li J, et al. CSF biomarkers for early-onset Alzheimer’s disease in Chinese population from PUMCH dementia cohort. Front Neurol. 2023;9(13):1030019. https://doi.org/10.3389/fneur.2022.1030019
  34. Mendez MF. Early-onset Alzheimer Disease and Its Variants. Continuum (Minneap Minn). 2019;25(1):34-51.  https://doi.org/10.1212/CON.0000000000000687
  35. Wattmo C, Wallin AK. Early-versus late-onset Alzheimer’s disease in clinical practice: cognitive and global outcomes over 3 years. Alzheimers Res Ther. 2017;9(1):70.  https://doi.org/10.1186/s13195-017-0294-2
  36. Hermann P, Zerr I. Rapidly progressive dementias — aetiologies, diagnosis and management. Nat Rev Neurol. 2022;18(6):363-376.  https://doi.org/10.1038/s41582-022-00659-0
  37. Chitravas N, Jung RS, Kofskey DM, et al. Treatable neurological disorders misdiagnosed as Creutzfeldt-Jakob disease. Ann Neurol. 2011;70(3):437-444.  https://doi.org/10.1002/ana.22454
  38. Peckeu L, Delasnerie-Lauprètre N, Brandel JP, et al. Accuracy of diagnosis criteria in patients with suspected diagnosis of sporadic Creutzfeldt-Jakob disease and detection of 14-3-3 protein, France, 1992 to 2009. Euro Surveill. 2017;22(41):16-00715. https://doi.org/10.2807/1560-7917.ES.2017.22.41.16-00715
  39. Day GS, Musiek ES, Morris JC. Rapidly Progressive Dementia in the Outpatient Clinic: More Than Prions. Alzheimer Dis Assoc Disord. 2018;32(4):291-297.  https://doi.org/10.1097/WAD.0000000000000276
  40. Wallin AK, Blennow K, Zetterberg H, et al. CSF biomarkers predict a more malignant outcome in Alzheimer disease. Neurology. 2010;74(19):1531-1537. https://doi.org/10.1212/WNL.0b013e3181dd4dd8
  41. Schmidt C, Haïk S, Satoh K, et al. Rapidly progressive Alzheimer’s disease: a multicenter update. J Alzheimers Dis. 2012;30(4):751-756. 
  42. Tosto G, Gasparini M, Brickman AM, et al. Neuropsychological predictors of rapidly progressive Alzheimer’s disease. Acta Neurol Scand. 2015;132(6):417-422.  https://doi.org/10.1111/ane.12415
  43. Moschetti K, Barragan N, Basurto-Davila R, et al. Mortality and Productivity Losses from Alzheimer Disease Among US Adults Aged 40 to 64 Years, 1999 to 2010. Alzheimer Dis Assoc Disord. 2015;29(2):165-168.  https://doi.org/10.1097/WAD.0000000000000017
  44. Stanley K, Walker Z. Do patients with young onset Alzheimer’s disease deteriorate faster than those with late onset Alzheimer’s disease? A review of the literature. Int Psychogeriatr. 2014;26(12):1945-1953. https://doi.org/10.1017/S1041610214001173
  45. Gerritsen AA, Bakker C, Verhey FR, et al. Prevalence of comorbidity in patients with young-onset Alzheimer disease compared with late-onset: a comparative cohort study. J Am Med Dir Assoc. 2016;17(4):318-323.  https://doi.org/10.1016/j.jamda.2015.11.011
  46. Chen Y, Sillaire AR, Dallongeville J, et al. Low prevalence and clinical effect of vascular risk factors in early-onset Alzheimer’s disease. J Alzheimers Dis. 2017;60(3):1045-1054.
  47. Palasi A, Gutierrez-Iglesias B, Alegret M, et al. Differentiated clinical presentation of early and late-onset Alzheimer’s disease: is 65 years of age providing a reliable threshold? J Neurol. 2015;262(5):1238-1246. https://doi.org/10.1007/s00415-015-7698-3
  48. Joubert S, Gour N, Guedj E, et al. Earlyonset and late-onset Alzheimer’s disease are associated with distinct patterns of memory impairment. Cortex. 2016;74:217-22.  https://doi.org/10.1016/j.cortex.2015.10.014
  49. Koberskaya NN. Difficulties of Differential Diagnosis of Early-onset Alzheimer’s Disease: a Clinical Case. Nervniy Bolezni. 2023;3:46-52. (In Russ.). https://doi.org/10.24412/2226-0757-2023-13006
  50. Migliaccio R, Agosta F, Possin KL, et al. Mapping the progression of atrophy in early- and late onset Alzheimer’s disease. J Alzheimers Dis. 2015;46(2):351-364. 
  51. Cho H, Jeon S, Kang SJ, et al. Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer’s disease. Neurobiol Aging. 2013;34(7):9-15.  https://doi.org/10.1016/j.neurobiolaging.2013.01.004
  52. Loreto F, Gontsarova A, Scott G, et al. Visual atrophy rating scales and amyloid PET status in an Alzheimer’s disease clinical cohort. Ann Clin Transl Neurol. 2023;10(4):619-631.  https://doi.org/10.1002/acn3.51749
  53. Enkirch SJ, Traschütz A, Müller A, et al. The ERICA Score: An MR Imaging-based Visual Scoring System for the Assessment of Entorhinal Cortex Atrophy in Alzheimer Disease. Radiology. 2018;288(1):226-333.  https://doi.org/10.1148/radiol.2018171888
  54. Igarashi KM. Entorhinal cortex dysfunction in Alzheimer’s disease. Trends Neurosci. 2023;46(2):124-136.  https://doi.org/10.1016/j.tins.2022.11.006
  55. Karas G, Scheltens P, Rombouts S, et al. Precuneus atrophy in early-onset Alzheimer’s disease: a morphometric structural MRI study. Neuroradiology. 2007;49(12):967-976.  https://doi.org/10.1007/s00234-007-0269-2

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