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Kovalenko E.A.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies

Makhnovich E.V.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies

Bogolepova A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Osinovskaya N.A.

Federal Center of Brain Research and Neurotechnologies

Beregov M.M.

Federal Center of Brain Research and Neurotechnologies

Features of the clinical and neuroimaging picture in patients with early-onset Alzheimer’s disease

Authors:

Kovalenko E.A., Makhnovich E.V., Bogolepova A.N., Osinovskaya N.A., Beregov M.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4‑2): 56‑63

DOI: 10.17116/jnevro202412404256

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Table of contents

FEATURES OF THE CLINICAL AND NEUROIMAGING PICTURE IN PATIENTS WITH EARLY-ONSET ALZHEIMER’S DISEASE
FEATURES OF THE CLINICAL AND NEUROIMAGING PICTURE IN PATIENTS WITH EARLY-ONSET ALZHEIMER’S DISEASE

To cite this article:

Kovalenko EA, Makhnovich EV, Bogolepova AN, Osinovskaya NA, Beregov MM. Features of the clinical and neuroimaging picture in patients with early-onset Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4‑2):56‑63. (In Russ.)
https://doi.org/10.17116/jnevro202412404256

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

The most common cause of severe cognitive impairment in adults is Alzheimer’s disease (AD). Depending on the age of onset, AD is divided into early (<65 years) and late (≥65 years) forms. Early-onset AD (EOAD) is significantly less common than later-onset AD (LOAD) and accounts for only about 5—10% of cases. However, its medical and social significance, as a disease leading to loss of ability to work and legal capacity, as well as premature death in patients aged 40-64 years, is extremely high. Patients with EOAD compared with LOAD have a greater number of atypical clinical variants — 25% and 6—12.5%, respectively, which complicates the differential diagnosis of EOAD with other neurodegenerative diseases. However, the typical classical amnestic variant predominates in both EOAD and LOAD. Also, patients with EOAD have peculiarities according to neuroimaging data: when performing MRI of the brain, patients with EOAD often have more pronounced parietal atrophy and less pronounced hippocampal atrophy compared to patients with LOAD. The article pays attention to the features of the clinical and neuroimaging data in patients with EOAD; a case of a patient with EOAD is presented.

Keywords:

early-onset Alzheimer’s disease
clinical picture
brain MRI
neuroimaging
clinical case

Authors:

Kovalenko E.A.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies

Makhnovich E.V.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies

Bogolepova A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Osinovskaya N.A.

Federal Center of Brain Research and Neurotechnologies

Beregov M.M.

Federal Center of Brain Research and Neurotechnologies

Received:

18.01.2024

Accepted:

19.02.2024

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