A clinical case of a rare acquired disease, namely Kaposi’s sarcoma developed in a man at the age of 22 is presented. The patient applied for a consultation in June 2024 to the National Center for Burns and Dermatology of the Ministry of Health of the Republic of Armenia. He came with complaints of the neoplasm occurrence on the neck’s anterior surface 3 months ago, not accompanied by subjective sensations, but gradually increasing in size. According to the medical history, it has been established that the patient was found to be HIV-infected 6 months ago. Pinkish-purple solitary domed node 6mm in diameter, with solid-elastic texture and painless in palpation was noted on the skin of the neck’s anterior surface in the patient’s examination. In the dermatoscopy of the node, polychromia (iridescent pattern), perifocal hyperpigmentation of brown color (brown collar), polymorphous (hairpin-like and punctate) vessels, variably sized white lumps, thick orthogonal lines, as well as a blood clot in the central part of the node were visualized. Pathological studies of the affected skin were performed to clarify the diagnosis. Histopathological study: skin flap is lined with epidermis without signs of keratinocytes’ atypia, tumor node in derma, developed by multidirectional fascicles, formed by fusiform-shaped atypical cells with pleomorphic nuclei, between which slit-like vascular spaces are located. Immunohistochemical study: diffuse nuclear expression of human herpes virus 8 in the fusiform cells. The following diagnosis was established based on the medical history, clinical picture and results of the examination: Kaposi’s sarcoma, HIV-associated form, node stage of development. The presented clinical case is of interest to dermatologists due to the rare incidence of Kaposi’s sarcoma in clinical practice and the difficulty of diagnosing this disease.