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Poluektov M.G.

Sechenov First Moscow State Medical University (Sechenov University)

Spektor E.D.

Sechenov First Moscow State Medical University (Sechenov University)

Molecular and cellular mechanisms of restorative effects of sleep

Authors:

Poluektov M.G., Spektor E.D.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(5‑2): 15‑20

DOI: 10.17116/jnevro202312305215

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Table of contents

MOLECULAR AND CELLULAR MECHANISMS OF RESTORATIVE EFFECTS OF SLEEP
MOLECULAR AND CELLULAR MECHANISMS OF RESTORATIVE EFFECTS OF SLEEP

To cite this article:

Poluektov MG, Spektor ED. Molecular and cellular mechanisms of restorative effects of sleep. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(5‑2):15‑20. (In Russ.)
https://doi.org/10.17116/jnevro202312305215

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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Abstract:

The review article enlightens contemporary concept about a role of sleep in cellular energy metabolism, neuroplasticity and glymphatic clearance of waste products. Many researches have demonstrated that prolonged wakefulness is an energetic and a neurophysiologic issue for the brain. The article provides description of biochemical processes that are responsive for energy restoration in sleep, particularly the role of ATP, adenosine and glycogen. Energy metabolism substrates depletion leads to endoplasmic reticulum stress and unfolded protein response. At the same time the conductance of synapses increases that worsens energetic problems. Level of the glymphatic clearance during wakefulness is substantially lower in comparison with sleep, and waste products are not removed fast enough.

Keywords:

sleep
adenosine
glycogen
unfolded protein response
synaptic homeostasis theory
neuroplasticity
glymphatic system

Authors:

Poluektov M.G.

Sechenov First Moscow State Medical University (Sechenov University)

Spektor E.D.

Sechenov First Moscow State Medical University (Sechenov University)

Received:

28.03.2023

Accepted:

28.03.2023

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