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Popova E.V.

Kafedra nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia vracheĭ Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Kiselev I.S.

GBOU VPO «Rossiĭskiĭ natsionalnyĭ issledovatelskiĭ meditsinskiĭ universitet im. N.I. Pirogova» Minzdrava RF, Moskva

Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

Sivertseva S.A.

Tiumenskiĭ oblastnoĭ tsentr rasseiannogo skleroza

Malkova N.A.

Novosibirskiĭ okruzhnoĭ tsentr rasseiannogo skleroza

Korobko D.S.

Oblastnoĭ tsentr rasseiannogo skleroza, Gosudarstvennaia novosibirskaia oblastnaia klinicheskaia bol'nitsa

Spirin N.N.

Kafedra nervnykh bolezneĭ i meditsinskoĭ genetiki s kursom neĭrokhirurgii Iaroslavskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Kasatkin D.S.

Poliklinika #5, Iaroslavl'

Karaeva A.V.

Sverdlovsk Regional Clinical Hospital №1, Yekaterinburg, Russia

Turova E.L.

GBUZ «Sverdlovskaja oblastnaja klinicheskaja bolnitsa №1», Ekaterinburg

Spirina N.N.

Kafedra nervnykh bolezneĭ s meditsinskoĭ genetikoĭ i neĭrokhirurgieĭ Iaroslavskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Volkova L.I.

Ural State Medical Academy, Ekaterinburg

Baulina N.M.

GBOU VPO «Rossiĭskiĭ natsionalnyĭ issledovatelskiĭ meditsinskiĭ universitet im. N.I. Pirogova» Minzdrava RF, Moskva

Bashinskaja V.V.

GBOU VPO «Rossiĭskiĭ natsionalnyĭ issledovatelskiĭ meditsinskiĭ universitet im. N.I. Pirogova» Minzdrava RF, Moskva

Kulakova O.G.

Kafedra nevrologii i neĭrokhirurgii i kafedra molekuliarnoĭ biologii i biotekhnologii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta im. N.I. Pirogova, Moskva

Favorova O.O.

Kafedra nevrologii i neĭrokhirurgii i kafedra molekuliarnoĭ biologii i biotekhnologii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta im. N.I. Pirogova, Moskva

Polymorphic variants of the immune response genes as risk factors for primary progressive multiple sclerosis

Authors:

Popova E.V., Kiselev I.S., Boĭko A.N., Sivertseva S.A., Malkova N.A., Korobko D.S., Spirin N.N., Kasatkin D.S., Karaeva A.V., Turova E.L., Spirina N.N., Volkova L.I., Baulina N.M., Bashinskaja V.V., Kulakova O.G., Favorova O.O.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(2‑2): 14‑21

DOI: 10.17116/jnevro20171172214-21

Read: 2700 times

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Table of contents

POLYMORPHIC VARIANTS OF THE IMMUNE RESPONSE GENES AS RISK FACTORS FOR PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS
POLYMORPHIC VARIANTS OF THE IMMUNE RESPONSE GENES AS RISK FACTORS FOR PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS

To cite this article:

Popova EV, Kiselev IS, Boĭko AN, et al. Polymorphic variants of the immune response genes as risk factors for primary progressive multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(2‑2):14‑21. (In Russ.)
https://doi.org/10.17116/jnevro20171172214-21

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

Objective. To analyze the involvement of immune response genes in the pathogenesis of primary progressive multiple sclerosis (PPMS). Material and methods. This multicenter study included 111 patients with PPMS from the Russian ethnic group. The association of PPMS with genes of immune system was analyzed by the study of polymorphic variants of genes of cytokines and genes of antigen-presenting cells. Results and conclusion. The genotypes of IL-4 (rs2243250)*C/C and CLEC16A (rs6498169)*G/G were associated with PPMS in Russians. The association between the HLA-DRB1*15 and PPMS found out in other populations was confirmed in Russians.

Keywords:

genes
immune response
risk faktors
primary progressive multiple sclerosis

Authors:

Popova E.V.

Kafedra nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia vracheĭ Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Kiselev I.S.

GBOU VPO «Rossiĭskiĭ natsionalnyĭ issledovatelskiĭ meditsinskiĭ universitet im. N.I. Pirogova» Minzdrava RF, Moskva

Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

Sivertseva S.A.

Tiumenskiĭ oblastnoĭ tsentr rasseiannogo skleroza

Malkova N.A.

Novosibirskiĭ okruzhnoĭ tsentr rasseiannogo skleroza

Korobko D.S.

Oblastnoĭ tsentr rasseiannogo skleroza, Gosudarstvennaia novosibirskaia oblastnaia klinicheskaia bol'nitsa

Spirin N.N.

Kafedra nervnykh bolezneĭ i meditsinskoĭ genetiki s kursom neĭrokhirurgii Iaroslavskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Kasatkin D.S.

Poliklinika #5, Iaroslavl'

Karaeva A.V.

Sverdlovsk Regional Clinical Hospital №1, Yekaterinburg, Russia

Turova E.L.

GBUZ «Sverdlovskaja oblastnaja klinicheskaja bolnitsa №1», Ekaterinburg

Spirina N.N.

Kafedra nervnykh bolezneĭ s meditsinskoĭ genetikoĭ i neĭrokhirurgieĭ Iaroslavskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Volkova L.I.

Ural State Medical Academy, Ekaterinburg

Baulina N.M.

GBOU VPO «Rossiĭskiĭ natsionalnyĭ issledovatelskiĭ meditsinskiĭ universitet im. N.I. Pirogova» Minzdrava RF, Moskva

Bashinskaja V.V.

GBOU VPO «Rossiĭskiĭ natsionalnyĭ issledovatelskiĭ meditsinskiĭ universitet im. N.I. Pirogova» Minzdrava RF, Moskva

Kulakova O.G.

Kafedra nevrologii i neĭrokhirurgii i kafedra molekuliarnoĭ biologii i biotekhnologii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta im. N.I. Pirogova, Moskva

Favorova O.O.

Kafedra nevrologii i neĭrokhirurgii i kafedra molekuliarnoĭ biologii i biotekhnologii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta im. N.I. Pirogova, Moskva

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