Objective. To study risk factors for ischemic stroke (II) in patients from the Dagestan Republic. Material and methods. We studied 135 patients (57 women and 78 men) with II, aged from 52-82 years (mean age 68.22±8.25 years). Results and conclusion. The main risk factors for II were: arterial hypertension and cerebral atherosclerosis; 58.5% patients had stenocardia, 34.1% fibrillary oscillation, 17.8% diabetes mellitus, 67.4% excessive body mass, 19.3 survived myocardial infarction and 10.4 - II, 35.6% patients smoked. Hemodynamia, dyslipidemia, distress, diabetes mellitus, myocardial infarction were more often noted in patients from flat regions, excessive body mass and smoking were risk factors for patients from sub-mountain areas and arterial hypertension, cerebral atherosclerosis, fibrillary oscillation for patients from mountain regions.