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Vladimirsky V.E.

Wagner Perm State Medical University

Vladimirsky E.V.

Wagner Perm State Medical University

Lunina A.N.

Wagner Perm State Medical University

Fesyun A.D.

National Medical Research Centre for Rehabilitation and Balneology

Rachin A.P.

National Research Medical Center for Rehabilitation and Balneology

Lebedeva O.D.

National Medical Research Center for Rehabilitation and Balneology

Yakovlev M.Yu.

National Medical Research Center for Rehabilitation and Balneology

Tubekova M.A.

Pulmonology Research Institute of Federal Medico — Biological Agency

Molecular mechanisms of adaptive and therapeutic effects of physical activity in patients with cardiovascular diseases

Authors:

Vladimirsky V.E., Vladimirsky E.V., Lunina A.N., Fesyun A.D., Rachin A.P., Lebedeva O.D., Yakovlev M.Yu., Tubekova M.A.

More about the authors

Journal: Problems of Balneology, Physiotherapy and Exercise Therapy. 2022;99(2): 69‑77

DOI: 10.17116/kurort20229902169

Read: 2127 times

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Table of contents

MOLECULAR MECHANISMS OF ADAPTIVE AND THERAPEUTIC EFFECTS OF PHYSICAL ACTIVITY IN PATIENTS WITH CARDIOVASCULAR DISEASES
MOLECULAR MECHANISMS OF ADAPTIVE AND THERAPEUTIC EFFECTS OF PHYSICAL ACTIVITY IN PATIENTS WITH CARDIOVASCULAR DISEASES

To cite this article:

Vladimirsky VE, Vladimirsky EV, Lunina AN, et al. . Molecular mechanisms of adaptive and therapeutic effects of physical activity in patients with cardiovascular diseases. Problems of Balneology, Physiotherapy and Exercise Therapy. 2022;99(2):69‑77. (In Russ.)
https://doi.org/10.17116/kurort20229902169

Подписка 2026 Вопросы курортологии, физиотерапии и лечебной физической культуры (Problems of Balneology, Physiotherapy and Exercise Therapy)
 
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Abstract:

Physical activity is one of the main components of the rehabilitation of patients with cardiovascular disease (CVD). As shown by practice and the results of evidence-based studies, the beneficial effects of physical activity on disease outcomes in a number of cardiac nosologies are comparable to drug treatment. This gives the doctor another tool to influence the unfavorable epidemiological situation in developed countries with the spread of diseases of the cardiovascular system and CVD mortality. Reliable positive results of cardiorehabilitation (CR) were obtained using various methods. The goal of CR is to restore the optimal physiological, psychological and professional status, reduce the risk of CVD and mortality. In most current CVD guidelines worldwide, cardiac rehabilitation is a Class I recommendation. The molecular mechanisms described in the review, initiated by physical activity, underlie the multifactorial effect of the latter on the function of the cardiovascular system and the course of cardiac diseases. Physical exercise is an important component of the therapeutic management of patients with CVD, which is supported by the results of a meta-analysis of 63 studies associated with various forms of aerobic exercise of varying intensity (from 50 to 95% VO2) for 1 to 47 months, which showed that CR based on physical exercise improves cardiorespiratory endurance. Knowledge of the molecular basis of the influence of physical activity makes it possible to use biochemical markers to assess the effectiveness of rehabilitation programs.

Keywords:

molecular mechanisms
cardiorehabilitation
cardiovascular diseases
physical exercise
physiological adaptation
cardiorespiratory endurance

Authors:

Vladimirsky V.E.

Wagner Perm State Medical University

Vladimirsky E.V.

Wagner Perm State Medical University

Lunina A.N.

Wagner Perm State Medical University

Fesyun A.D.

National Medical Research Centre for Rehabilitation and Balneology

Rachin A.P.

National Research Medical Center for Rehabilitation and Balneology

Lebedeva O.D.

National Medical Research Center for Rehabilitation and Balneology

Yakovlev M.Yu.

National Medical Research Center for Rehabilitation and Balneology

Tubekova M.A.

Pulmonology Research Institute of Federal Medico — Biological Agency

Received:

24.01.2021

Accepted:

30.07.2021

Close metadata

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