Bacterial microbiota in exacerbation of chronic purulent otitis media in children

Kulmakov SA, Soldatskiy YuL, Polunin MM, Minasyan VS, Edgem SR, Ivanenko AM, Zhilina SV. Bacterial microbiota in exacerbation of chronic purulent otitis media in children. Russian Bulletin of Otorhinolaryngology. 2023;88(5):7‑11. (In Russ.)
https://doi.org/10.17116/otorino2023880517

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)

Использование инфографики авторами научных работ

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OBJECTIVE

To study current spectrum of bacterial pathogens that cause exacerbation of chronic suppurative otitis media (CSOM) in children, who live in Moscow region, and to investigate sensitivity of isolated strains to various antibacterial drugs.

MATERIAL AND METHODS

The results of microbiome’s bacterial cultivation of purulent discharge from tympanic cavities collected from 269 children with CSOM aged from 1.5 to 18 years for the period from 2017 to 2021 yr. were analyzed. The majority of examined subjects (70.6% from 190 children) had CSOM with cholesteatoma.

RESULTS

Monoculture was received in 62.5% of examined patients, bacterial associations — in 25.7%, bacterial-fungal associations — in 2.6%, and there was no growth in 9.2% of subjects. Staphylococcus aureus, which was found in 36.1% of children, dominated among agents. Pseudomonas aeruginosa was the second most frequently diagnosed agent, revealed in 12.3% of patients. Candida spp. (7.1%) was prevalent in bacterial-fungal associations. The article presents the results of isolated strains’ sensitivity to antibacterial drugs. The high resistance to oxacillin, cefoxitin and antipseudomonal drugs was found among strains collected from children with CSOM and cholesteatoma.

CONCLUSION

S. aureus (36.1%) and P. aeruginosa (12.3%) remain the most common causative agents for exacerbation of chronic suppurative otitis media in children. Pathogenic fungi are not isolated separately, and Candida spp. (6.7%) dominates in bacterial-fungal associations. It is generally recognized and confirmed by our research, that topical fluoruquinolones (ciprofloxacin) are the most effective drugs for exacerbation of chronic suppurative otitis media treatment. Systemic antibiotics, of which fluoruquinolones (ciprofloxacin) are the most effective, are recommended in severe exacerbation, severe and destructive forms of chronic suppurative otitis media.

Keywords:

acute suppurative otitis media

chronic suppurative otitis media

cholesteatoma

treatment

Authors:

Kulmakov S.A.

Morozov Children’s City Clinical Hospital

ORCID: 0000-0003-0951-5548

Soldatskiy Yu.L.

Morozov Children’s City Clinical Hospital

ORCID: 0000-0003-0046-9944

Polunin M.M.

Morozov Children’s City Clinical Hospital;
Pirogov Russian National Research Medical University

ORCID: 0000-0002-9086-726X

Minasyan V.S.

Morozov Children’s City Clinical Hospital;
Pirogov Russian National Research Medical University

ORCID: 0000-0001-6174-2735

Edgem S.R.

Morozov Children’s City Clinical Hospital

ORCID: 0000-0003-4236-6361

Ivanenko A.M.

Morozov Children’s City Clinical Hospital

ORCID: 0000-0003-1650-8864

Zhilina S.V.

Morozov Children’s City Clinical Hospital

ORCID: 0000-0003-0084-1013

Received:

27.05.2022

Accepted:

13.06.2022

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