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Kunelskaya N.L.

L. I. Sverzhevsky Research Clinical Institute of Otorhinolaryngology;
Pirogov Russian National Research Medical University

Garov E.V.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

Garova E.E.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Yanyushkina E.S.

Sverzhevskiy Research Clinical Institute of Otorhinolaryngology

Nikitkina Ya.Yu.

Sverzhevky Research Institute of Clinical Otorhinolaryngology

Manaenkova E.A.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

Pryakhina M.A.

Pirogov Russian National Research Medical University

Kovtun O.V.

L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology

Glucocorticosteroids in the treatment of acute neurosensory hearing loss. The current state of the problem. Part 2

Authors:

Kunelskaya N.L., Garov E.V., Garova E.E., Yanyushkina E.S., Nikitkina Ya.Yu., Manaenkova E.A., Pryakhina M.A., Kovtun O.V.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2022;87(5): 70‑74

DOI: 10.17116/otorino20228705170

Read: 21564 times

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Table of contents

GLUCOCORTICOSTEROIDS IN THE TREATMENT OF ACUTE NEUROSENSORY HEARING LOSS. THE CURRENT STATE OF THE PROBLEM. PART 2
GLUCOCORTICOSTEROIDS IN THE TREATMENT OF ACUTE NEUROSENSORY HEARING LOSS. THE CURRENT STATE OF THE PROBLEM. PART 2

To cite this article:

Kunelskaya NL, Garov EV, Garova EE, et al. . Glucocorticosteroids in the treatment of acute neurosensory hearing loss. The current state of the problem. Part 2. Russian Bulletin of Otorhinolaryngology. 2022;87(5):70‑74. (In Russ.)
https://doi.org/10.17116/otorino20228705170

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Modern literature data are presented on the choice of a drug for hormonal therapy in acute neurosensory hearing loss of various origins, the doses used for systemic therapy, the features and methods of intratympanic administration of glucocorticosteroids, and the evaluation of the effectiveness of treatment with this group of drugs.

Keywords:

acute sensorineural hearing loss
glucocorticosteroids
treatment

Authors:

Kunelskaya N.L.

L. I. Sverzhevsky Research Clinical Institute of Otorhinolaryngology;
Pirogov Russian National Research Medical University

Garov E.V.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

Garova E.E.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Yanyushkina E.S.

Sverzhevskiy Research Clinical Institute of Otorhinolaryngology

Nikitkina Ya.Yu.

Sverzhevky Research Institute of Clinical Otorhinolaryngology

Manaenkova E.A.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

Pryakhina M.A.

Pirogov Russian National Research Medical University

Kovtun O.V.

L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology

Received:

13.08.2021

Accepted:

07.10.2021

Close metadata

References:

  1. Parnes L, Sun A, Freeman D. Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application. Laryngoscope. 1999;109(S91):1-17.  https://doi.org/10.1097/00005537-199907001-00001
  2. Vlastarakos P, Papacharalampous G, Maragoudakis P, Kampessis G, Maroudias N, Candiloros D, Nikolopoulos T. Are intra-tympanically administered steroids effective in patients with sudden deafness? Implications for current clinical practice. European Archives of Oto-Rhino-Laryngology. 2012;269:363-380.  https://doi.org/10.1007/s00405-011-1738-0
  3. Niedermeyer H, Zahneisen G, Luppa P, Busch R, Arnold W. Cortisol levels in the human perilymph after intravenous administration of prednisolone. Audiology and Neuro-Otology. 2003;8:316-321.  https://doi.org/10.1159/000073516
  4. Leung M, Flaherty A, Zhang J, Hara J, Barber W, Burgess L. Sudden sensorineural hearing loss: primary care update. Hawai’i Journal of Medicine and Public Health. 2016;75(6):172-174. Accessed August 1, 2021. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928516/
  5. MacArthur C, Hausman F, Kempton B, Trune D. Intratympanic steroid treatments may improve hearing via ion homeostasis alterations and not immune suppression. Otology and Neurotology. 2015;36(6):1089-1095. https://doi.org/10.1097/MAO.0000000000000725
  6. Chandrasekhar SS, Tsai Do BS, Schwartz SR, Bontempo LJ, Faucett EA, Finestone SA, Hollingsworth DB, Kelley DM, Kmucha ST, Moonis G, Poling GL, Roberts JK, Stachler RJ, Zeitler DM, Corrigan MD, Nnacheta LC, Satterfield L. Clinical practice guideline: sudden hearing loss (Update). Otolaryngology — Head and Neck Surgery. 2019;161(IS):1-45.  https://doi.org/10.1177/0194599819859885
  7. Singh A, Kumar Irugu D. Sudden sensorineural hearing loss — a contemporary review of management issues. Journal of Otology. 2019;15(2):67-73.  https://doi.org/10.1016/j.joto.2019.07.001
  8. Nosrati‐Zarenoe R, Hultcrantz E. Corticosteroid treatment of idiopathic sudden sensorineural hearing loss: randomized triple‐blind placebo‐controlled trial. Otology and Neurotology. 2012;33(4): 523‐531.  https://doi.org/10.1097/MAO.0b013e31824b78da
  9. Plontke S. Diagnostics and therapy of sudden hearing loss. GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery. 2018;16:Doc05. https://doi.org/10.3205/cto000144
  10. Eastwood H, Chang A, Kel G, Sly D, Richardson R, O’Leary S. Round window delivery of dexamethasone ameliorates local and remote hearing loss produced by cochlear implantation into the second turn of the guinea pig cochlea. Hearing Research. 2010;265(1-2):25-29.  https://doi.org/10.1016/j.heares.2010.03.006
  11. Lai D, Zhao F, Jalal N, Zheng Y. Intratympanic glucocorticosteroid therapy for idiopathic sudden hearing loss: meta-analysis of randomized controlled trials. Medicine. 2017;96(50):e8955. https://doi.org/10.1097/MD.0000000000008955
  12. Kakehata S, Sasaki A, Oji K, Futai K, Ota Sh, Makinae K, Shinkawa H. Comparison of intratympanic and intravenous dexamethasone treatment on sudden sensorineural hearing loss with diabetes. Otology and Neurotology. 2006;27(5):604-608.  https://doi.org/10.1097/01.mao.0000224092.79635.ee
  13. Chew S, Daud M. The efficacy of intratympanic steroid injection for the treatment of idiopathic sudden sensorineural hearing loss. Medical Journal of Malaysia. 2020;75(1):74-77. Accessed August 1, 2021. https://www.e-mjm.org/2020/v75n1/hearing-loss.pdf
  14. Ermutlu G, Süslü N, Yılmaz T, Saraç S. Sudden hearing loss: an effectivity comparison of intratympanic and systemic steroid treatments. European Archives of Oto-Rhino-Laryngology. 2017;274:3585-3591. https://doi.org/10.1007/s00405-017-4691-8
  15. Lechner M, Sutton L, Ferguson M, Abbas Y, Sandhu J, Shaida A. Intratympanic steroid use for sudden sensorineural hearing loss: current otolaryngology practice. Annals of Otology, Rhinology and Laryngology. 2019;128(6):490-502.  https://doi.org/10.1177/0003489419828759
  16. Kosyakov SYa, Atanesyan AG, Gunenkov AV. Local therapy of acute sensorineural hearing loss by intrampanal administration of steroids. Vestnik otolaringologii. 2012;(3):74-78. 
  17. Yi Q, Shixun Zh, Guohua H, Houyong K, Ling W, Yan L. Sudden sensorineural hearing loss in children: a report of 75 cases. Otology and Neurotology. 2018;39(8):1018-1024. https://doi.org/10.1097/MAO.0000000000001891
  18. Hong S, Park C, Lee J. Hearing outcomes of daily intratympanic dexamethasone alone as a primary treatment modality for ISSHL. Otolaryngology —— Head and Neck Surgery. 2009;141(5):579-583.  https://doi.org/10.1016/j.otohns.2009.08.009
  19. Filipo R, Attanasio G, Russo F, Viccaro M, Mancini P, Covelli E. Intratympanic steroid therapy in moderate sudden hearing loss: a randomized, triple-blind, placebo-controlled trial. Laryngoscope. 2013;123:774-778.  https://doi.org/10.1002/lary.23678
  20. Spear S, Schwartz S. Intratympanic steroids for sudden sensorineural hearing loss: a systematic review. Otolaryngology — Head and Neck Surgery. 2011;145(4):534-543.  https://doi.org/10.1177/0194599811419466
  21. Rauch SD, Halpin CF, Antonelli PJ, Babu S, Carey JP, Gantz BJ, Goebel JA, Hammerschlag PE, Harris JP, Isaacson B, Lee D, Linstrom CJ, Parnes LS, Shi H, Slattery WH, Telian SA, Vrabec JT, Reda DJ. Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: a randomized trial. JAMA. 2011;305(20):2071-2079. https://doi.org/10.1001/jama.2011.679
  22. Dispenza F, Amodio E, De Stefano A, Gallina S, Marchese D, Mathur N, Riggio F. Treatment of sudden sensorineural hearing loss with transtympanic injection of steroids as single therapy: a randomized clinical study. European Archives of Oto-Rhino-Laryngology. 2011;268(9):1273-1278. https://doi.org/10.1007/s00405-011-1523-0
  23. Lee J, Jang J, Choo O, Lim H, Choung Y. Steroid intracochlear distribution differs by administration method: systemic versus intratympanic injection. Laryngoscope. 2018;128(1):189-194.  https://doi.org/10.1002/lary.26562
  24. Kunel’skaya NL, Garov YeV, Garova YeYe, Yanyushkina YeS, Pryakhina MA, Yakusheva MO, Larionova EV. Sposob prolongatsii deystviya lekarstvennogo preparata pri intratimpanal’nom vvedenii na struktury vnutrennego ukha. Patent RF na izobreteniye №2749692. Zayavka №2020142670 ot 23.12.20. Izobreteniya, poleznyye modeli. Ofitsial’nyy byulleten’ federal’noy sluzhby po intellektual’noy sobstvennosti, patentam i tovarnym znakam №17 ot 16.06.21. (In Russ). https://findpatent.ru/patent/274/2749692.html
  25. Plontke S, Glien A, Rahne T, Mäder K, Salt A. Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic sudden sensorineural hearing loss. Otology and Neurotology. 2014;35(7):1168-1171. https://doi.org/10.1097/MAO.0000000000000434
  26. Si Y, Jiang H, Chen Y, Chu Y, Chen S, Chen X, He W, Zheng Y, Zhang Z. Round window niche drilling with Intratympanic steroid is a salvage therapy of sudden hearing loss. Audiology and Neuro-Otology. 2018;23:309-315.  https://doi.org/10.1159/000493086
  27. Svistushkin VM, Nikiforova GN, Morozova SV, Gergiev VF, Ershova EN. Alternative methods of steroid delivery to the middle ear in the treatment of acute sensorineural hearing loss. Meditsinskii sovet. 2020;(6):85-89. (In Russ.). https://doi.org/10.21518/2079-701X-2020-6-85-89
  28. Plontke S, Löwenheim H, Mertens J, Engel C, Meisner C, Weidner A, Zimmermann R, Preyer S, Koitschev A, Zenner H. Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic therapy. Laryngoscope. 2009;119(2):359-369.  https://doi.org/10.1002/lary.20074
  29. Silverstein H, Thompson J, Rosenberg S, Brown N, Light J. Silverstein MicroWick. Otolaryngologic Clinics of North America. 2004;37(5):1019-1034. https://doi.org/10.1016/j.otc.2004.04.002
  30. Wijck F van, Staecker H, Lefebvre P. Topical steroid therapy using the Silverstein Microwick in sudden sensorineural hearing loss after failure of conventional treatment. Acta Oto-Laryngologica. 2007;127(10):1012-1017. https://doi.org/10.1080/00016480601126952
  31. Trune D, Canlon B. Corticosteroid therapy for hearing and balance disorders. Anatomical Record. 2012;295(11):1928-1943. https://doi.org/10.1002/ar.22576
  32. Filipo R, Covelli E, Balsamo G, Attanasio G. Intratympanic prednisolone therapy for sudden sensorineural hearing loss: a new protocol. Acta Oto-Laryngologica. 2010;130:1209-1213. https://doi.org/10.3109/00016481003793766
  33. Demirhan H, Gökduman A, Hamit B, Yürekli Altındağ M, Yiğit Ö. Contribution of intratympanic steroids in the primary treatment of sudden hearing loss. Acta Oto-Laryngologica. 2018;138(7): 648-651.  https://doi.org/10.1080/00016489.2018.1438660
  34. Nakashima T, Sato H, Gyo K, Hato N, Yoshida T, Shimono M, Teranishi M, Sone M, Fukunaga Y, Kobashi G, Takahashi K, Matsui S, Ogawa K. Idiopathic sudden sensorineural hearing loss in Japan. Acta Oto-Laryngologica. 2014;134(11):1158-1163. https://doi.org/10.3109/00016489.2014.919406
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