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Kryukov A.I.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology;
Pirogov Russian National Research Medical University

Kunelskaya N.L.

L. I. Sverzhevsky Research Clinical Institute of Otorhinolaryngology;
Pirogov Russian National Research Medical University

Garov E.V.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

Stepanova E.A.

M.F. Vladimirsky Moscow Regional Clinical Research Institute

Sudarev P.A.

Sverzhevskiy Research Clinical Institute of Otorhinolaryngology

Yanyushkina E.S.

Sverzhevskiy Research Clinical Institute of Otorhinolaryngology

Abramenko A.S.

M. F. Vladimirsky Moscow Regional Research Clinical Institute

Garova E.E.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Larionova E.V.

L.I. Sverzhevsky Scientific Research Clinical Institute of Otorhinolaryngology

The effectiveness of transtympanic use of dexamethasone 4 mg in Meniere’s disease, severe and moderate course of the disease

Authors:

Kryukov A.I., Kunelskaya N.L., Garov E.V., Stepanova E.A., Sudarev P.A., Yanyushkina E.S., Abramenko A.S., Garova E.E., Larionova E.V.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2022;87(1): 21‑26

DOI: 10.17116/otorino20228701121

Views: 2397

Downloaded: 81

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To cite this article:

Kryukov AI, Kunelskaya NL, Garov EV, et al. . The effectiveness of transtympanic use of dexamethasone 4 mg in Meniere’s disease, severe and moderate course of the disease. Russian Bulletin of Otorhinolaryngology. 2022;87(1):21‑26. (In Russ.)
https://doi.org/10.17116/otorino20228701121

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)
 
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The results of transtympanic administration of 4 mg dexamethasone in 37 patients with moderate and severe Meniere’s disease are presented. The endolymphatic hydrops was detected in all inner ear structures with predominant accumulation in vestibule and semicircular canals by MRI-visualization before therapy. After 1 month of 4 mg dexamethasone transtympanic therapy the hydrops degree decreased. Daily transtympanic administration of 4 mg dexamethasone for a month leads to reduction of vertigo attacks duration and expression in 92% of cases (follow-up period 24 months) and can be considered when conservative therapy is ineffective before destructive surgical interventions.

Keywords:

Meniere’s disease
endolymphatic hydrops
magnetic resonance imaging
contrast substance
vertigo attack

Authors:

Kryukov A.I.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology;
Pirogov Russian National Research Medical University

Kunelskaya N.L.

L. I. Sverzhevsky Research Clinical Institute of Otorhinolaryngology;
Pirogov Russian National Research Medical University

Garov E.V.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

Stepanova E.A.

M.F. Vladimirsky Moscow Regional Clinical Research Institute

Sudarev P.A.

Sverzhevskiy Research Clinical Institute of Otorhinolaryngology

Yanyushkina E.S.

Sverzhevskiy Research Clinical Institute of Otorhinolaryngology

Abramenko A.S.

M. F. Vladimirsky Moscow Regional Research Clinical Institute

Garova E.E.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Larionova E.V.

L.I. Sverzhevsky Scientific Research Clinical Institute of Otorhinolaryngology

Received:

12.05.2021

Accepted:

20.06.2021

List of references:

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