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Krakhmaleva D.A.

Krasnov Research Institute of Eye Diseases, Moscow, Russia

Ilina P.N.

Krasnov Research Institute of Eye Diseases, Moscow, Russia;
RUDN University, Moscow, Russia

Terrien’s marginal degeneration: clinical manifestations, diagnosis, and treatment

Authors:

Krakhmaleva D.A., Ilina P.N.

More about the authors

Journal: Russian Annals of Ophthalmology. 2026;142(2): 100‑106

DOI: 10.17116/oftalma2026142021100

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Table of contents

TERRIEN’S MARGINAL DEGENERATION: CLINICAL MANIFESTATIONS, DIAGNOSIS, AND TREATMENT
TERRIEN’S MARGINAL DEGENERATION: CLINICAL MANIFESTATIONS, DIAGNOSIS, AND TREATMENT

To cite this article:

Krakhmaleva DA, Ilina PN. Terrien’s marginal degeneration: clinical manifestations, diagnosis, and treatment. Russian Annals of Ophthalmology. 2026;142(2):100‑106. (In Russ.)
https://doi.org/10.17116/oftalma2026142021100

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Terrien’s marginal degeneration is a rare idiopathic condition characterized by minimally symptomatic, typically bilateral peripheral corneal thinning without ulceration, accompanied by superficial neovascularization and lipid deposition. The absence of pathognomonic diagnostic criteria, along with the diversity of clinical manifestations and potential complications, can make establishing the diagnosis more difficult. This review summarizes current knowledge regarding the etiopathogenesis, clinical course, and diagnostic features of Terrien’s marginal degeneration. It also discusses contemporary classifications and current approaches to differential diagnosis and treatment of the disease.

Keywords:

corneal degeneration
corneal confocal microscopy
corneal topography
optical coherence tomography
corneal cross-linking
crescentic lamellar keratoplasty

Authors:

Krakhmaleva D.A.

Krasnov Research Institute of Eye Diseases, Moscow, Russia

Ilina P.N.

Krasnov Research Institute of Eye Diseases, Moscow, Russia;
RUDN University, Moscow, Russia

Received:

03.09.2025

Accepted:

13.11.2025

Close metadata

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