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Babaeva D.B.

Pirogov National Medical and Surgical Center;
Institute for Advanced Training of Physicians of the Pirogov National Medical and Surgical Center

Fayzrakhmanov R.R.

Pirogov National Medical and Surgical Center;
Institute for Advanced Training of Physicians of the Pirogov National Medical and Surgical Center

Larina E.A.

Pirogov National Medical and Surgical Center;
Institute for Advanced Training of Physicians of the Pirogov National Medical and Surgical Center

Daloglanyan A.A.

Institute for Advanced Training of Physicians of the Pirogov National Medical and Surgical Center

Kamisheva K.V.

Institute for Advanced Training of Physicians of the Pirogov National Medical and Surgical Center

Molecular diagnostic biomarkers of subretinal fluid in assessing the severity and prognosis of rhegmatogenous retinal detachment

Authors:

Babaeva D.B., Fayzrakhmanov R.R., Larina E.A., Daloglanyan A.A., Kamisheva K.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2025;141(6): 119‑126

DOI: 10.17116/oftalma2025141061119

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Table of contents

MOLECULAR DIAGNOSTIC BIOMARKERS OF SUBRETINAL FLUID IN ASSESSING THE SEVERITY AND PROGNOSIS OF RHEGMATOGENOUS RETINAL DETACHMENT
MOLECULAR DIAGNOSTIC BIOMARKERS OF SUBRETINAL FLUID IN ASSESSING THE SEVERITY AND PROGNOSIS OF RHEGMATOGENOUS RETINAL DETACHMENT

To cite this article:

Babaeva DB, Fayzrakhmanov RR, Larina EA, Daloglanyan AA, Kamisheva KV. Molecular diagnostic biomarkers of subretinal fluid in assessing the severity and prognosis of rhegmatogenous retinal detachment. Russian Annals of Ophthalmology. 2025;141(6):119‑126. (In Russ.)
https://doi.org/10.17116/oftalma2025141061119

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The article presents a comprehensive review of current studies devoted to diagnostic approaches involving molecular markers of subretinal fluid (SRF) in rhegmatogenous retinal detachment (RRD). The qualitative and quantitative features of SRF components are examined, including proteins associated with coagulation cascade, proteolysis, and neuronal injury, as well as the dynamics of these components in the early stages of the disease. Particular attention is given to the role of inflammatory cytokines (IL-6, -1α, CCL19) and proliferation factors (TGF-β2) involved in the pathogenesis of RRD and the development of proliferative changes, highlighting their potential as biomarkers for assessing damage severity and predicting outcomes. The review also presents modern methods for noninvasive evaluation of SRF, specifically optical coherence tomography (OCT) that provides new diagnostic opportunities. The article emphasizes the importance of an integrated approach, combining clinical data, laboratory parameters, and noninvasive methods to improve prognostic accuracy and effectiveness of therapy, and outlines the prospects for further research into novel molecular markers and the development of corresponding diagnostic algorithms, which will help optimize the management of patients with RRD, reduce time and resource costs, and improve the quality of life of patients.

Keywords:

rhegmatogenous retinal detachment
proliferative vitreoretinopathy
subretinal fluid
interleukins
optical coherence tomography
vitreoretinal surgery
visual acuity
treatment prognosis

Authors:

Babaeva D.B.

Pirogov National Medical and Surgical Center;
Institute for Advanced Training of Physicians of the Pirogov National Medical and Surgical Center

Fayzrakhmanov R.R.

Pirogov National Medical and Surgical Center;
Institute for Advanced Training of Physicians of the Pirogov National Medical and Surgical Center

Larina E.A.

Pirogov National Medical and Surgical Center;
Institute for Advanced Training of Physicians of the Pirogov National Medical and Surgical Center

Daloglanyan A.A.

Institute for Advanced Training of Physicians of the Pirogov National Medical and Surgical Center

Kamisheva K.V.

Institute for Advanced Training of Physicians of the Pirogov National Medical and Surgical Center

Received:

03.07.2025

Accepted:

13.08.2025

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References:

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