Cytomegalovirus retinitis affecting the posterior pole of the eye is the most common opportunistic infection in acquired immunodeficiency syndrome (AIDS). It typically develops at CD₄ lymphocyte levels below 50—100 cells/μL and, if untreated, leads to blindness. Much less frequently, cytomegalovirus infection results in choroiditis, followed by secondary retinal changes. This article presents a clinical case of cytomegalovirus chorioretinitis in a human immunodeficiency virus-infected patient.