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Filippov V.M.

Research Institute of Eye Diseases

Petrachkov D.V.

Research Institute of Eye Diseases

Budzinskaya M.V.

Krasnov Research Institute of Eye Diseases

Sidamonidze A.L.

Research Institute of Eye Diseases

Modern concepts of pathogenesis of diabetic retinopathy

Authors:

Filippov V.M., Petrachkov D.V., Budzinskaya M.V., Sidamonidze A.L.

More about the authors

Journal: Russian Annals of Ophthalmology. 2021;137(5‑2): 306‑313

DOI: 10.17116/oftalma2021137052306

Read: 6353 times

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Table of contents

MODERN CONCEPTS OF PATHOGENESIS OF DIABETIC RETINOPATHY
MODERN CONCEPTS OF PATHOGENESIS OF DIABETIC RETINOPATHY

To cite this article:

Filippov VM, Petrachkov DV, Budzinskaya MV, Sidamonidze AL. Modern concepts of pathogenesis of diabetic retinopathy. Russian Annals of Ophthalmology. 2021;137(5‑2):306‑313. (In Russ.)
https://doi.org/10.17116/oftalma2021137052306

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This literature review presents modern view on the pathogenesis of diabetic retinopathy (DR) paying particular attention to the molecular mechanisms leading to its development, as well as the manifestations of retinal neurodegeneration in such patients. Assessment of this condition and its clinical manifestations makes it possible to diagnose DR at the stage of absent initial vascular changes. Investigating the neurodegeneration mechanisms could supplement the existing understanding of the disease pathogenesis and could possibly help find new ways of treatment and prevention of DR.

Keywords:

diabetes mellitus
diabetic retinopathy
pathogenesis
neurodegeneration

Authors:

Filippov V.M.

Research Institute of Eye Diseases

Petrachkov D.V.

Research Institute of Eye Diseases

Budzinskaya M.V.

Krasnov Research Institute of Eye Diseases

Sidamonidze A.L.

Research Institute of Eye Diseases

Received:

25.11.2020

Accepted:

27.04.2021

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References:

  1. Dedov II, Shestakova MV, Mayorov AYu, et al. Algorithms of specialized medical care for patients with diabetes mellitus. Sakharnyj diabet. 2019;22(S1-1): 1-144. (In Russ.). https://doi.org/10.14341/DM221S1
  2. IDF DIABETES ATLAS Ninth edition 2019. Accessed July 25, 2021. https://www.diabetesatlas.org
  3. Wild S, Roglic G, Green A, Sicree R, King H. Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047-1053. https://doi.org/10.2337/diacare.27.5.1047
  4. Federal’nyj reestr bol’nykh sakharnym diabetom. Accessed October 30, 2020. (In Russ.). https://www.diaregistry.ru
  5. Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, et al. Meta-Analysis for Eye Disease (META-EYE) Study Group. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012;35(3):556-564.  https://doi.org/10.2337/dc11-1909
  6. Klein BE. Overview of epidemiologic studies of diabetic retinopathy. Ophthalmic Epidemiology. 2007;14(4):179-183.  https://doi.org/10.1080/09286580701396720
  7. Flaxman SR, Bourne RRA, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, Das A, Jonas JB, Keeffe J, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Silvester A, Stevens GA, Tahhan N, Wong TY, Taylor HR; Vision Loss Expert Group of the Global Burden of Disease Study. Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis. The Lancet Global Health. 2017;5(12): 1221-1234. https://doi.org/10.1016/S2214-109X(17)30393-5
  8. Bikbov MM, Fayzrakhmanov RR, Kazakbaeva GM, Zainullin RM, Arslangareeva II, Gilmanshin TR, Salavatova VF, Nikitin NA, Mukhamadieva SR, Yakupova DF, Khikmatullin RI, Zaynetdinov AF, Uzianbaeva YV, Aminev SK, Nuriev IF, Jonas JB. Prevalence, awareness and control of diabetes in Russia: The Ural Eye and Medical Study on adults aged 40+ years. PLoS One. 2019;14(4):e0215636. https://doi.org/10.1371/journal.pone.0215636
  9. MacKenzie SA. Case of Glycosuric Retinitis, with Comments. (Microscopical Examination of the Eyes by Mr. Nettleship). Royal London Ophthalmic Hospital Reports. 1879;9:134. 
  10. Ballantyne A, Loewenstein A. The Pathology of Diabetic Retinopathy. Transactions of the Ophthalmological Societies of the United Kingdom. 1943;63: 95-115. 
  11. Porta M, Kohner E. Screening for diabetic retinopathy in Europe. Diabetic Medicine. 1991;8(3):197-198.  https://doi.org/10.1111/j.1464-5491.1991.tb01571.x
  12. Gatsu MV, Balashevich LI. Classification of diabetic retinopathy. Oftal’mologicheskie vedomosti. 2009;2(4):52-58. (In Russ.).
  13. Grading diabetic retinopathy from stereoscopic color fundus photographs — an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1991;98(5 Suppl):786-806.  https://doi.org/10.1016/S0161-6420(13)38012-9
  14. Early Treatment Diabetic Retinopathy Study design and baseline patient characteristics. ETDRS report number 7. Ophthalmology. 1991;98(5 Suppl): 741-756.  https://doi.org/10.1016/s0161-6420(13)38009-9
  15. Budzinskaya MV, Petrachkov DV, Savochkina OA, Arzhukhanov DD. On the classification of diabetic retinopathy. Vestnik oftal’mologii. 2019;135(5): 272-277. (In Russ.). https://doi.org/10.17116/oftalma2019135052272
  16. Wolter JR. Diabetic Retinopathy. American Journal of Ophthalmology. 1961; 51:1123-1141. https://doi.org/10.1016/0002-9394(61)91802-5
  17. Bloodworth JM. Diabetic retinopathy. Diabetes. 1962;11:1-22. 
  18. Kurtenbach A, Wagner U, Neu A, Schiefer U, Ranke MB, Zrenner E. Brightness matching and colour discrimination in young diabetics without retinopathy. Vision Research. 1994;34(1):115-122.  https://doi.org/10.1016/0042-6989(94)90262-3
  19. Sokol S, Moskowitz A, Skarf B, Evans R, Molitch M, Senior B. Contrast sensitivity in diabetics with and without background retinopathy. Archives of Ophthalmology. 1985;103(1):51-54.  https://doi.org/10.1001/archopht.1985.01050010055018
  20. Caputo S, Di Leo MA, Falsini B, Ghirlanda G, Porciatti V, Minella A, Greco AV. Evidence for Early Impairment of Macular Function with Pattern ERG in Type I Diabetic Patients. Diabetes Care. 1990;13(4):412-418.  https://doi.org/10.2337/diacare.13.4.412
  21. Biallosterski C, van Velthoven MEJ, Michels RPJ, Schlingemann RO, DeVries JH, Verbraak FD. Decreased optical coherence tomography-measured pericentral retinal thickness in patients with diabetes mellitus type 1 with minimal diabetic retinopathy. British Journal of Ophthalmology. 2007; 91(9):1135-1138. https://doi.org/10.1136/bjo.2006.111534
  22. van Dijk HW, Kok PH, Garvin M, Sonka M, Devries JH, Michels RP, van Velthoven ME, Schlingemann RO, Verbraak FD, Abràmoff MD. Selective loss of inner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy. Investigative Ophthalmology and Visual Science. 2009; 50(7):3404-3409. https://doi.org/10.1167/iovs.08-3143
  23. Sdobnikova SV, Makhotin SS, Sdobnikova LE. On the need to create a new classification of proliferative diabetic retinopathy. Meditsinskij vestnik Bashkortostana. 2018;13(1):40-44. (In Russ.).
  24. Feng Y, Busch S, Gretz N, Hoffmann S, Hammes HP. Crosstalk in the retinal neurovascular unit — lessons for the diabetic retina. Experimental and Clinical Endocrinology and Diabetes. 2012;120(4):199-201.  https://doi.org/10.1055/s-0032-1304571
  25. Barber AJ. Diabetic retinopathy: recent advances towards understanding neurodegeneration and vision loss. Science China. Life Sciences. 2015;58(6): 541-549.  https://doi.org/10.1007/s11427-015-4856-x
  26. Van de Kreeke JA, Darma S, Chan Pin Yin JMPL, Tan HS, Abramoff MD, Twisk JWR, Verbraak FD. The spatial relation of diabetic retinal neurodegeneration with diabetic retinopathy. PLoS One. 2020;15(4):e0231552. https://doi.org/10.1371/journal.pone.0231552
  27. Gartner LP, Hiatt JL. Cell Biology and Histology. Seventh edition. Wolters Kluwer Health; 2015.
  28. Zlobin IV, Zhukova SI, Yuryeva TN. Visualization of retinal blood flow disorders in acute retinal ischemia syndrome. Vestnik oftal’mologii. 2020;136(5): 116-122. (In Russ.). https://doi.org/10.17116/oftalma2020136051116
  29. Chesnokova NB, Pavlenko TA, Beznos OV, Grigoryev AV. The role of the endothelin system in the pathogenesis of eye diseases. Vestnik oftal’mologii. 2020;136(1):117-123. (In Russ.). https://doi.org/10.17116/oftalma2020136011117
  30. Sheludchenko VM, Kozlovskaya NL, Smirnova TV, Krasnolutskaya EI. Ophthalmological aspects of vascular and functional changes in malignant arterial hypertension of renal origin. Vestnik oftal’mologii. 2020;136(4/2):324-332. (In Russ.). https://doi.org/10.17116/oftalma2020136042324
  31. Aznabaev BM, Aleksandrov AA, Davletova RA, Nigmatullina LI, Nugmanova AR. Quantitative assessment of macular hemoperfusion in patients with non-proliferative diabetic retinopathy. Meditsinskij vestnik Bashkortostana. 2019;14(3):5-9. (In Russ.).
  32. Wangsa-Wirawan ND, Linsenmeier RA. Retinal oxygen: fundamental and clinical aspects. Archives of Ophthalmology. 2003;121(4):547-557.  https://doi.org/10.1001/archopht.121.4.547
  33. Kur J, Newman EA, Chan-Ling T. Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. Progress in Retinal and Eye Research. 2012;31(5):377-406.  https://doi.org/10.1016/j.preteyeres.2012.04.004
  34. Moran EP, Wang Z, Chen J, Sapieha P, Smith LEH, Ma J. Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications. American Journal of Physiology. Heart and Circulatory Physiology. 2016;311(3):738-749.  https://doi.org/10.1152/ajpheart.00005.2016
  35. Sdobnikova SV, Revishchin AV, Makhotin SS, Pavlova GV, Sdobnikova LE. Features of the architectonics of the newly formed vascular system in diabetic retinopathy. Meditsinskij vestnik Bashkortostana. 2018;13(1):44-48. (In Russ.).
  36. Kats MV, Sdobnikova LE, Bychkova AD, Revishchin AV, Sdobnikova SV. Possibilities of modern methods of pathomorphological study of neoangiogenesis of the retina in diabetic retinopathy. Sovremennye tekhnologii v oftal’mologii. 2019;4:124-126. (In Russ.). https://doi.org/10.25276/2312-4911-2019-4-124-126
  37. Pratt CW, Cornely K. Essential Biochemistry. 4th Edition. Wiley; 2017.
  38. Germer A, Biedermann B, Wolburg H, Schuck J, Grosche J, Kuhrt H, Reichelt W, Schousboe A, Paasche G, Mack AF, Reichenbach A. Distribution of mitochondria within Müller cells-I. Correlation with retinal vascularization in different mammalian species. Journal of Neurocytology. 1998; 27(5):329-345.  https://doi.org/10.1023/a:1006934724566
  39. Bentmann A, Schmidt M, Reuss S, Wolfrum U, Hankeln T, Burmester T. Divergent distribution in vascular and avascular mammalian retinae links neuroglobin to cellular respiration. The Journal of Biological Chemistry. 2005;280(21):20660-20665. https://doi.org/10.1074/jbc.M501338200
  40. Bristow EA, Griffiths PG, Andrews RM, Johnson MA, Turnbull DM. The distribution of mitochondrial activity in relation to optic nerve structure. Archives of Ophthalmology. 2002;120(6):791-796.  https://doi.org/10.1001/archopht.120.6.791
  41. Heng LZ, Comyn O, Peto T, Tadros C, Ng E, Sivaprasad S, Hykin PG. Diabetic retinopathy: pathogenesis, clinical grading, management and future developments. Diabetic Medicine. 2013;30(6):640-650.  https://doi.org/10.1111/dme.12089
  42. Hammes HP. Pericytes and the pathogenesis of diabetic retinopathy. Hormone and Metabolic Research. 2005;37(Suppl 1):39-43.  https://doi.org/10.1055/s-2005-861361
  43. Ljubimov AV, Burgeson RE, Butkowski RJ, Couchman JR, Zardi L, Ninomiya Y, Sado Y, Huang ZS, Nesburn AB, Kenney MC. Basement membrane abnormalities in human eyes with diabetic retinopathy. The Journal of Histochemistry and Cytochemistry. 1996;44(12):1469-1479. https://doi.org/10.1177/44.12.8985139
  44. Gardiner TA, Archer DB, Curtis TM, Stitt AW. Arteriolar involvement in the microvascular lesions of diabetic retinopathy: implications for pathogenesis. Microcirculation. 2007;14(1):25-38.  https://doi.org/10.1080/10739680601072123
  45. Curtis TM, Gardiner TA, Stitt AW. Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis? Eye. 2009;23(7):1496-1508. https://doi.org/10.1038/eye.2009.108
  46. Barber AJ, Lieth E, Khin SA, Antonetti DA, Buchanan AG, Gardner TW. Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. The Journal of Clinical Investigation. 1998;102(4): 783-791.  https://doi.org/10.1172/JCI2425
  47. Barber AJ. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuro-Psych Biol Psych. 2003;27(2):283-290.  https://doi.org/10.1016/S0278-5846(03)00023-X
  48. Antonetti DA, Barber AJ, Bronson SK, Freeman WM, Gardner TW, Jefferson LS, Kester M, Kimball SR, Krady JK, LaNoue KF, Norbury CC, Quinn PG, Sandirasegarane L, Simpson IA; JDRF Diabetic Retinopathy Center Group. Diabetic Retinopathy: Seeing Beyond Glucose-Induced Microvascular Disease. Diabetes. 2006;55(9):2401-2411. https://doi.org/10.2337/db05-1635
  49. Barber AJ, Gardner TW, Abcouwer SF. The Significance of Vascular and Neural Apoptosis to the Pathology of Diabetic Retinopathy. Investigative Ophthalmology and Visual Science. 2011;52(2):1156. https://doi.org/10.1167/iovs.10-6293
  50. Lieth E, Gardner TW, Barber AJ, Antonetti DA; Penn State Retina Research Group. Retinal neurodegeneration: early pathology in diabetes. Clinical and Experimental Ophthalmology. 2000;28(1):3-8.  https://doi.org/10.1046/j.1442-9071.2000.00222.x
  51. Barber AJ, Baccouche B. Neurodegeneration in diabetic retinopathy: Potential for novel therapies. Vision Research. 2017;139:82-92.  https://doi.org/10.1016/j.visres.2017.06.014
  52. Chakravarthy H, Devanathan V. Molecular Mechanisms Mediating Diabetic Retinal Neurodegeneration: Potential Research Avenues and Therapeutic Targets. Journal of Molecular Neuroscience: MN. 2018;66(3):445-461.  https://doi.org/10.1007/s12031-018-1188-x
  53. Duh EJ, Sun JK, Stitt AW. Diabetic retinopathy: current understanding, mechanisms, and treatment strategies. JCI Insight. 2017;2(14):e93751. https://doi.org/10.1172/jci.insight.93751
  54. Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Levison SW. Diabetic retinopathy: more than meets the eye. Survey of Ophthalmology. 2002;47 (Suppl 2):253-262.  https://doi.org/10.1016/s0039-6257(02)00387-9
  55. Hernández C, Simó R. Neurodegeneration in diabetic retinopathy: Current concepts and therapeutic implications. Avances en Diabetología. 2014;30(3): 72-79.  https://doi.org/10.1016/j.avdiab.2014.03.003
  56. Kadlubowska J, Malaguarnera L, Waz P, Zorena K. Neurodegeneration and Neuroinflammation in Diabetic Retinopathy: Potential Approaches to Delay Neuronal Loss. Current Neuropharmacology. 2016;14(8):831-839.  https://doi.org/10.2174/1570159X14666160614095559
  57. Muc R, Saracen A, Grabska-Liberek I. Associations of diabetic retinopathy with retinal neurodegeneration on the background of diabetes mellitus. Overview of recent medical studies with an assessment of the impact on healthcare systems. Open Medicine. 2018;13(1):130-136.  https://doi.org/10.1515/med-2018-0008
  58. Kowluru RA, Engerman RL, Case GL, Kern TS. Retinal glutamate in diabetes and effect of antioxidants. Neurochemistry International. 2001;38(5): 385-390.  https://doi.org/10.1016/S0197-0186(00)00112-1
  59. Zhang Y, Bhavnani BR. Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens. BMC Neuroscience. 2006;7:49.  https://doi.org/10.1186/1471-2202-7-49
  60. Puro DG. Diabetes-induced dysfunction of retinal Müller cells. Transactions of the American Ophthalmological Society. 2002;100:339-352. 
  61. Lucas DR, Newhouse JP. The toxic effect of sodium L-glutamate on the inner layers of the retina. A.M.A. Archives of Ophthalmology. 1957;58(2): 193-201.  https://doi.org/10.1001/archopht.1957.00940010205006
  62. Li Q, Puro DG. Diabetes-induced dysfunction of the glutamate transporter in retinal Müller cells. Investigative Ophthalmology and Visual Science. 2002; 43(9):3109-3116.
  63. Chihara E, Sakugawa M, Entani S. Reduced protein synthesis in diabetic retina and secondary reduction of slow axonal transport. Brain Research. 1982;250(2):363-366.  https://doi.org/10.1016/0006-8993(82)90432-2
  64. Yang S, Xu L, Yang T, Wang F. High-mobility group box-1 and its role in angiogenesis. Journal of Leukocyte Biology. 2014;95(4):563-574.  https://doi.org/10.1189/jlb.0713412
  65. Stem M, Gardner T. Neurodegeneration in the Pathogenesis of Diabetic Retinopathy: Molecular Mechanisms and Therapeutic Implications. Current Medicinal Chemistry. 2013;20(26):3241-3250. https://doi.org/10.2174/09298673113209990027
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