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Zaytseva O.V.

Helmholtz National Medical Research Center of Eye Diseases;
A.I. Evdokimov Moscow State University of Medicine and Dentistry

Neroeva N.V.

Helmholtz National Medical Research Center of Eye Diseases

Okhotsimskaya T.D.

Helmholtz National Medical Research Center of Eye Diseases

Bobykin E.V.

Ural State Medical University

Anti-VEGF therapy for neovascular age-related macular degeneration: causes of incomplete response

Authors:

Zaytseva O.V., Neroeva N.V., Okhotsimskaya T.D., Bobykin E.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2021;137(5): 152‑159

DOI: 10.17116/oftalma2021137051152

Views: 2307

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Table of contents

ANTI-VEGF THERAPY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: CAUSES OF INCOMPLETE RESPONSE
ANTI-VEGF THERAPY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: CAUSES OF INCOMPLETE RESPONSE

To cite this article:

Zaytseva OV, Neroeva NV, Okhotsimskaya TD, Bobykin EV. Anti-VEGF therapy for neovascular age-related macular degeneration: causes of incomplete response. Russian Annals of Ophthalmology. 2021;137(5):152‑159. (In Russ.)
https://doi.org/10.17116/oftalma2021137051152

Подписка 2025-2 (Russian Annals of Ophthalmology)
 
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Neovascular age-related macular degeneration (nAMD) is one of the leading causes of decreased vision in the elderly population in many countries, including Russia. Anti-VEGF therapy is undoubtedly the «gold standard» of treatment for the disease, but its use in different patients is known to produce results with significant interindividual differences. This article reviews modern ideas about the clinical assessment of the degree of response to anti-VEGF therapy, possible reasons for its insufficient effectiveness (clinical, pharmacological, or related to nAMD pathogenesis), discusses the potential applications of the existing therapeutic strategies, and considers the prospects for the emergence of new strategies that could be used for solving that problem.

Keywords:

age-related macular degeneration
anti-VEGF therapy
macular neovascularization
resistance
incomplete response

Authors:

Zaytseva O.V.

Helmholtz National Medical Research Center of Eye Diseases;
A.I. Evdokimov Moscow State University of Medicine and Dentistry

Neroeva N.V.

Helmholtz National Medical Research Center of Eye Diseases

Okhotsimskaya T.D.

Helmholtz National Medical Research Center of Eye Diseases

Bobykin E.V.

Ural State Medical University

Received:

09.07.2021

Accepted:

09.09.2021

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