Antiangiogenic therapy of neovascular age-related macular degeneration

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The problem associated with the prevalence of retinal diseases, and age-related macular degeneration (AMD) in particular, is undoubtedly relevant. This aspect is based on steadily growing statistics on morbidity, a high number of randomized controlled trials (RCT) and published real world data (RWD). The analysis of RCT results being published by researchers on 15.05.19 showed 2915 studies were registered on the subject of retinal diseases; that exceeds the number of studies on glaucoma by approximately 1.38 times (2118 studies) and conjunctival lesions by 2.37 times (1230 studies). AMD is one of the leading causes of irreversible vision loss and blindness; its neovascular form leads to blindness in 80—90% of all cases. Even though the topic of nAMD therapy is widely highlighted in modern ophthalmology, today there are many aspects that require targeted solutions. The main controversial issues that determine the complexity of therapy and patient management include discrepancies in determination of reference points (disease activity criteria) for implementation of anti-VEGF dosing regimens, patients’ compliance, prioritization issues in treatment, its continuity with potential for the increase of intervals between injections and monitoring visits.

Keywords:

age-related macular degeneration

neovascular AMD

ranibizumab

aflibercept

dosing regimen

T&E

treat-and-extend

Authors:

Fayzrakhmanov R.R.

Pirogov National Medical and Surgical Center

SPIN RSCI: 1620-0083
ORCID: 0000-0002-4341-3572

Voropaev V.Yu.

JSC Bayer

Sukhanova A.V.

Pirogov National Medical and Surgical Center

Shatalova E.O.

Clinics of doctor Shatalov

Received:

29.11.2020

Accepted:

24.12.2020

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