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Vlasova A.S.

West Siberian Institute of Postgraduate Medical Education

Petrov S.A.

West Siberian Institute of Postgraduate Medical Education;
Tyumen Scientific Center of the Siberian Branch of the Russian Academy of Sciences

Renzyak E.V.

West Siberian Institute of Postgraduate Medical Education;
District Clinical Hospital of the Khanty-Mansiysk Autonomous Okrug — Yugra

Neuroprotective therapy for age-related macular degeneration

Authors:

Vlasova A.S., Petrov S.A., Renzyak E.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2024;140(6): 152‑158

DOI: 10.17116/oftalma2024140061152

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NEUROPROTECTIVE THERAPY FOR AGE-RELATED MACULAR DEGENERATION
NEUROPROTECTIVE THERAPY FOR AGE-RELATED MACULAR DEGENERATION

To cite this article:

Vlasova AS, Petrov SA, Renzyak EV. Neuroprotective therapy for age-related macular degeneration. Russian Annals of Ophthalmology. 2024;140(6):152‑158. (In Russ.)
https://doi.org/10.17116/oftalma2024140061152

Подписка 2025-2 (Russian Annals of Ophthalmology)
 
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Age-related macular degeneration (AMD) is a chronic multifactorial degenerative eye disease and one of the leading causes of irreversible blindness worldwide. Despite extensive research, there is no consensus on the predominant pathological mechanism leading to photoreceptor death. AMD is associated with molecular and cellular disruptions that ultimately result in photoreceptor degeneration. This review summarizes data from international and Russian studies on the pathophysiological mechanisms underlying the development and progression of photoreceptor degeneration, presents scientific developments in therapeutic correction of these disturbances, and highlights promising avenues for pharmacological retinal neuroprotection that require further validation in clinical studies.

Keywords:

age-related macular degeneration
neuroprotection
retinal protection
peptide bioregulators
antioxidants
ethylmethylhydroxypyridine succinate

Authors:

Vlasova A.S.

West Siberian Institute of Postgraduate Medical Education

Petrov S.A.

West Siberian Institute of Postgraduate Medical Education;
Tyumen Scientific Center of the Siberian Branch of the Russian Academy of Sciences

Renzyak E.V.

West Siberian Institute of Postgraduate Medical Education;
District Clinical Hospital of the Khanty-Mansiysk Autonomous Okrug — Yugra

Received:

28.10.2024

Accepted:

25.11.2024

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