Brolucizumab, an angiogenesis inhibitor, is a single-chain fragment of a humanized antibody used to treat neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME). Although registration studies are the primary source of information on the new drug, post-marketing studies allow for further exploration and expansion of previous knowledge about its effectiveness, safety, and dosing regimens. This study summarizes the experience with brolucizumab from real-world clinical practice studies. A systematic literature review was conducted to identify articles published up to April 2024 that investigated the use of brolucizumab in the treatment of retinal vasogenic diseases, revealing the high effectiveness of brolucizumab compared to other angiogenesis inhibitors in the treatment of patients with nAMD and DME, including those who were treatment-naïve and those resistant to ongoing therapy, as well as patients with changes in the vitreoretinal interface. A significant advantage of brolucizumab is its ability to reduce the number of injections and extend the intervals between them up to 16 weeks. Study results demonstrate substantial improvements in anatomical and functional outcomes compared to previously existing and newly emerging angiogenesis inhibitors. Its ability to stabilize disease progression, achieve better disease control, and reduce injection frequency makes brolucizumab an attractive option for both first-line therapy and as a switching drug, highlighting its potential for expanded indications.