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Karpilova M.A.

Research Institute of Eye Diseases

Poluianova A.D.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Antioxidant nutraceuticals for glaucoma

Authors:

Karpilova M.A., Poluianova A.D.

More about the authors

Journal: Russian Annals of Ophthalmology. 2020;136(4): 317‑323

DOI: 10.17116/oftalma2020136042317

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Table of contents

ANTIOXIDANT NUTRACEUTICALS FOR GLAUCOMA
ANTIOXIDANT NUTRACEUTICALS FOR GLAUCOMA

To cite this article:

Karpilova MA, Poluianova AD. Antioxidant nutraceuticals for glaucoma. Russian Annals of Ophthalmology. 2020;136(4):317‑323. (In Russ.)
https://doi.org/10.17116/oftalma2020136042317

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Glaucoma is the leading cause of irreversible blindness in the world. Intraocular pressure (IOP) is currently the only proven modifiable risk factor for POAG. IOP-independent mechanisms contributing to the development of glaucomatous neurodegeneration include oxidative stress, excitotoxicity, mitochondrial dysfunction, and impaired ocular blood flow. In this regard, there has recently been growing interest in the use of various antioxidant dietary supplements as neuroprotective therapy for glaucoma. The issue of the effectiveness and safety of these biologically active additives is an urgent scientific problem reflected in numerous studies. This article reviews current concepts of oxidative/nitrosative stress, the role of reactive oxygen species (ROS)/reactive nitrogen (Nr) and their participation in the development of POAG, as well as experimental models and clinical studies using essential fatty acids, natural compounds and a number of other antioxidant substances that can counteract oxidative stress in glaucoma.

Keywords:

glaucoma
antioxidants
nutritional supplements

Authors:

Karpilova M.A.

Research Institute of Eye Diseases

Poluianova A.D.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Received:

04.04.2020

Accepted:

15.05.2020

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