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Karpilova M.A.
Research Institute of Eye Diseases
Poluianova A.D.
A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Antioxidant nutraceuticals for glaucoma
Journal: Russian Annals of Ophthalmology. 2020;136(4): 317‑323
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To cite this article:
Karpilova MA, Poluianova AD. Antioxidant nutraceuticals for glaucoma. Russian Annals of Ophthalmology.
2020;136(4):317‑323. (In Russ.)
https://doi.org/10.17116/oftalma2020136042317
Glaucoma is the leading cause of irreversible blindness in the world. Intraocular pressure (IOP) is currently the only proven modifiable risk factor for POAG. IOP-independent mechanisms contributing to the development of glaucomatous neurodegeneration include oxidative stress, excitotoxicity, mitochondrial dysfunction, and impaired ocular blood flow. In this regard, there has recently been growing interest in the use of various antioxidant dietary supplements as neuroprotective therapy for glaucoma. The issue of the effectiveness and safety of these biologically active additives is an urgent scientific problem reflected in numerous studies. This article reviews current concepts of oxidative/nitrosative stress, the role of reactive oxygen species (ROS)/reactive nitrogen (Nr) and their participation in the development of POAG, as well as experimental models and clinical studies using essential fatty acids, natural compounds and a number of other antioxidant substances that can counteract oxidative stress in glaucoma.
Keywords:
Authors:
Karpilova M.A.
Research Institute of Eye Diseases
Poluianova A.D.
A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Received:
04.04.2020
Accepted:
15.05.2020
List of references:
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