Three-component tear substitute as preoperative support in glaucoma surgery

Makashova N.V.; Vasillyeva A.E.; Kolosova O.Yu.

doi:https://doi.org/10.17116/oftalma202414003151

Makashova N.V.

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0003-1989-6612

Vasillyeva A.E.

Medical Center “Stolitsa”

ORCID: 0000-0001-5981-2423

Kolosova O.Yu.

Medical Center “Stolitsa”

ORCID: 0000-0001-6342-4888

Three-component tear substitute as preoperative support in glaucoma surgery

Authors:

Makashova N.V., Vasillyeva A.E., Kolosova O.Yu.

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Journal: Russian Annals of Ophthalmology. 2024;140(3): 51‑58

DOI: 10.17116/oftalma202414003151

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To cite this article:

Makashova NV, Vasillyeva AE, Kolosova OYu. Three-component tear substitute as preoperative support in glaucoma surgery. Russian Annals of Ophthalmology. 2024;140(3):51‑58. (In Russ.)
https://doi.org/10.17116/oftalma202414003151

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

Использование инфографики авторами научных работ

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PURPOSE

This study investigates the effect of preoperative preparation with the three-component tear substitute Stillavit on the outcomes of glaucoma surgery in patients on long-term topical glaucoma therapy.

MATERIAL AND METHODS

The study included 63 patients (63 eyes) with glaucoma, among them 30 (30 eyes) were women and 33 (33 eyes) were men. Group 1 consisted of 33 patients (33 eyes) receiving long-term topical antihypertensive therapy with preservatives and tear substitute Stillavit 3 times a day for 1 month as preoperative preparation. Group 2 included 30 patients (30 eyes) receiving similar antihypertensive therapy who were not prescribed preoperative medications. All patients underwent a comprehensive ophthalmological examination and computer tomography of the filtering blebs (FB) on Visante system (Carl Zeiss Meditec, Germany) before surgery, as well as 1 week, 1, 3, and 6 months after surgery.

RESULTS

Mean intraocular pressure (IOP) elevation at 6 months postoperatively was significantly higher in the group that did not undergo preoperative preparation with a tear substitute, compared to the group of patients who received the tear substitute Stillavit preoperatively. According to anterior segment optical coherence tomography, a greater number of favorable diffuse FB were noted in the group that received the tear substitute Stillavit in preparation for surgery — 87.9%, while in group 2 (without preparation) — 66.7%. Odds ratio calculation between the two groups revealed that preoperative preparation with the tear substitute Stillavit reduced the odds of IOP elevation to 20 mm Hg or higher at 3 months postoperatively by more than 10 times.

CONCLUSION

The use of tear substitute Stillavit in preparation for anti-glaucoma surgery reduces the chances of IOP elevation in the early postoperative period by more than 10 times, which may indicate a reduction in the rate of FB scarring due to the beneficial effect of the drug’s components on the precorneal tear film.

Keywords:

glaucoma surgery

glaucoma

bleb

optical tomography

artificial tear solution

Authors:

Makashova N.V.

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0003-1989-6612

Vasillyeva A.E.

Medical Center “Stolitsa”

ORCID: 0000-0001-5981-2423

Kolosova O.Yu.

Medical Center “Stolitsa”

ORCID: 0000-0001-6342-4888

Received:

06.04.2024

Accepted:

29.04.2024

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