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Kulybysheva V.S.

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021

Ronzina I.A.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Gamidov A.A.

FGBU "NII glaznykh bolezneĭ" RAMN

Neurodegenerative changes of the retina in patients with diabetes

Authors:

Kulybysheva V.S., Ronzina I.A., Gamidov A.A.

More about the authors

Journal: Russian Annals of Ophthalmology. 2019;135(5): 31‑37

DOI: 10.17116/oftalma201913505131

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NEURODEGENERATIVE CHANGES OF THE RETINA IN PATIENTS WITH DIABETES
NEURODEGENERATIVE CHANGES OF THE RETINA IN PATIENTS WITH DIABETES

To cite this article:

Kulybysheva VS, Ronzina IA, Gamidov AA. Neurodegenerative changes of the retina in patients with diabetes. Russian Annals of Ophthalmology. 2019;135(5):31‑37. (In Russ.)
https://doi.org/10.17116/oftalma201913505131

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Purpose — to investigate the morphological and functional state of the outer and inner layers of the retina in patients with diabetes mellitus (DM) and nonproliferative diabetic retinopathy (NPDR), to determine the presence and nature of the relationships between structural and functional changes. Material and methods. The study included 50 patients with subcompensated diabetes and NPDR and 40 people from the control group (healthy). All patients underwent OCT of the retina and optic nerve using RTVue-100 apparatus (Optovue, USA), as well as multifocal electroretinography (mfERG) and pattern electroretinography (PERG) on EP-1000 Multifocal device («Tomey GmbH», Germany). Results. When analyzing the results of OCT in patients with NPDR, a decrease in the total thickness of the retina and the thickness of its inner layers in the fovea and parafovea regions was found in comparison with the control group (p<0.001), thinning of the retinal ganglion cell (GCS) complex with increased focal losses (FLV) of up to 1.4% (Mann—Whitney test, p=0.001). In the group of patients with diabetes, there was a statistically significant decrease in the density and amplitude of P1 mfERG in all five «rings» (Mann—Whitney test, p<0.001), increase in implicit time in the first 3 rings, decrease in P50 and N95 amplitude, increase in implicit time of N95 PERG (p=0.001) compared to the control group. Conclusion. The study revealed changes in the structure and functioning of the outer and inner layers of the retina in patients with NPDR, and established a reliable correlation between the morphological parameters (according to the OCT) and electrophysiological parameters (according to the mfERG and PERG data).

Keywords:

diabetes mellitus
diabetic retinopathy
optical coherence tomography
electroretinography
neurodegeneration

Authors:

Kulybysheva V.S.

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021

Ronzina I.A.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Gamidov A.A.

FGBU "NII glaznykh bolezneĭ" RAMN

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