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Zueva M.V.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdravsotsrazvitiia Rossii

Tsapenko I.V.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Riabina M.V.

FGBU Moskovskiĭ nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ im. Gel'mgol'tsa Minzdrava RF, Moskva

Okhotsimskaia T.D.

FGBU Moskovskiĭ nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ im. Gel'mgol'tsa Minzdrava RF, Moskva

Grinchenko M.I.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Changes of retinal neurons and Muller glial cells in patients with type II diabetes in treatment of diabetic retinopathy with angiotensin-converting enzyme inhibitor

Authors:

Zueva M.V., Tsapenko I.V., Riabina M.V., Okhotsimskaia T.D., Grinchenko M.I.

More about the authors

Journal: Russian Annals of Ophthalmology. 2013;129(3): 44‑47

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Table of contents

CHANGES OF RETINAL NEURONS AND MULLER GLIAL CELLS IN PATIENTS WITH TYPE II DIABETES IN TREATMENT OF DIABETIC RETINOPATHY WITH ANGIOTENSIN-CONVERTING ENZYME INHIBITOR
CHANGES OF RETINAL NEURONS AND MULLER GLIAL CELLS IN PATIENTS WITH TYPE II DIABETES IN TREATMENT OF DIABETIC RETINOPATHY WITH ANGIOTENSIN-CONVERTING ENZYME INHIBITOR

To cite this article:

Zueva MV, Tsapenko IV, Riabina MV, Okhotsimskaia TD, Grinchenko MI. Changes of retinal neurons and Muller glial cells in patients with type II diabetes in treatment of diabetic retinopathy with angiotensin-converting enzyme inhibitor. Russian Annals of Ophthalmology. 2013;129(3):44‑47. (In Russ.)

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Flicker-ERG (FERG) amplitude and glial indices Cg were measured to estimate angiotensin- converting enzyme (ACE) inhibitor Perindopril effect on retinal glial-neuronal interactions in patients with type II diabetes and diabetic retinopathy (DR). Intake of 5 mg Perindopril daily during 2 months improved photoreceptor and bipolar cells function in all stages of DR with the most significant effect in preproliferative DR (PPDR). After treatment course initially supernormal FERG scotopic glial indices reduced by 8,3-12 Hz (25-33%) in nonproliferative DR and PPDR and by 10% in proliferative DR. In photopic conditions moderate decrease of index was revealed in FERG by 30Hz only in PPDR. Obtained results show Perindopril to cause significant improvement of retinal glial-neuronal interactions in dark adaptation and poor positive dynamics in photopic conditions.

Keywords:

diabetes mellitus
diabetic retinopathy
Muller cell
glial index
flicker-ERG
angiotensin- converting enzyme inhibitor
Perindopril

Authors:

Zueva M.V.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdravsotsrazvitiia Rossii

Tsapenko I.V.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Riabina M.V.

FGBU Moskovskiĭ nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ im. Gel'mgol'tsa Minzdrava RF, Moskva

Okhotsimskaia T.D.

FGBU Moskovskiĭ nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ im. Gel'mgol'tsa Minzdrava RF, Moskva

Grinchenko M.I.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

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