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Perinatal outcomes and immunological changes in pregnant women with new COVID-19 coronavirus infection
Journal: Russian Bulletin of Obstetrician-Gynecologist. 2023;23(5): 38‑44
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To cite this article:
Sakhautdinova IV, Zasyadkin IS, Khamad’yanova AU, Tayupova IM, Kuleshova TP. Perinatal outcomes and immunological changes in pregnant women with new COVID-19 coronavirus infection. Russian Bulletin of Obstetrician-Gynecologist.
2023;23(5):38‑44. (In Russ.)
https://doi.org/10.17116/rosakush20232305138
A review of scientific works published over the last 3 years concerning the issue of immunological changes and related perinatal outcomes in pregnant women with COVID-19 was carried out. It was found that pregnant women are more likely to have a severe course of COVID-19. This is largely due to immune changes in the pregnant woman’s body, as well as to the pathophysiology of COVID-19. This article discusses the main immunological changes, such as reduced levels of natural killer cells (NK cells), type 1 T-helper cells (Th1), plasmacytoid dendritic cells (pDCs), decreased phagocytic index of neutrophilic granulocytes and monocytes, as well as immunomodulatory properties of progesterone, the content of which is increased in pregnancy. Factors that may exacerbate the course of the disease due to hyperinflammatory states include an increase in the complement system, which is associated with more severe lung injury, and an increase in TLR-1 and TLR-7 toll-like receptors that bind to the virus, leading to increased production of pro-inflammatory cytokines such as IL-6 and TNF-α, which are elevated in the normal physiology of pregnancy. This leads to a higher incidence of pre-eclampsia, eclampsia, preterm labor and other adverse outcomes in pregnant women with COVID-19.
Authors:
Received:
08.02.2023
Accepted:
13.03.2023
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