Development of Point-Of-Care-Testing (POCT) platforms for differential infectious diseases diagnostics along with their integration into healthcare systems represent a vital necessity in the context of respiratory viral and bacterial infections rising prevalence, particularly considering recent COVID-19 experience, as well as new emerging threats. This study demonstrates the development and preliminary validation studies of the first POCT system, «Avtogen», developed In Russian Federation. The system provides fully automated RNA extraction using magnetic particles, followed by RT-LAMP real-time amplification and detection amplification. The assay’s turnaround time (TAT) takes less than forty minutes and requires minimal operator involvement. Evaluation of the system on model biological samples confirmed its efficacy in detecting SARS-CoV-2 RNA, with results comparable to the ones obtained using reagent kits approved by Russian Federal Service for Surveillance in Healthcare.