Redox regulation, eustress and distress in uncomplicated pregnancy and preeclampsia

Pozdnyakov I.M.; Shcherbakov V.I.; Shirinskaya A.V.

doi:https://doi.org/10.17116/rosakush20232303112

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Abstract:

This review article presents new data on oxidative stress that have been obtained in recent years, among them is the discovery of a negative regulator of reactive oxygen species, redoxome, and oxidative modification of proteins. Data are presented on the involvement of reactive oxygen species in angiogenesis, a key event in the formation of the placental vascular network. Physiological oxidative stress is discussed, which is combined with such a notion as physiological inflammation. In other words, a new perspective on inflammation is being developed, based on the demands of practice, as the form of inflammation in pre-eclampsia is still not defined. There is also a lack of proper understanding of the role of inflammation in normal pregnancy. It is also important that in a normal pregnancy there is a switch from Th1 inflammation during implantation to Th2 inflammation accompanying a normal pregnancy and a new switch to Th1 occurs before and during labor.

Keywords:

preeclampsia

oxidative stress

reactive oxygen species

Authors:

Pozdnyakov I.M.

Novosibirsk State Medical University;
Novosibirsk City Clinical Perinatal Centre

ORCID: 0000-0001-7942-9579

Shcherbakov V.I.

Federal Research Center for Fundamental and Experimental Medicine

ORCID: 0000-0002-0261-970X

Shirinskaya A.V.

Novosibirsk City Clinical Perinatal Centre

ORCID: 0000-0002-2470-7882

Received:

09.06.2022

Accepted:

04.08.2022

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References:

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