OBJECTIVE
To identify the biochemical parameters of menstrual blood in patients with chronic endometritis in infertility.
MATERIAL AND METHODS
The study was carried out at the Ivanovo V.N. Gorodkov Institute of Maternal and Child Health. Infertility patients aged 18 to 40 years (n=120): those with an isolated male factor of infertility in a married couple (a control group, n=30) and patients being treated for chronic endometritis and infertility (a main group, n=90) were examined. All women underwent standard comprehensive diagnostics as part of their pre-vitro preparation in accordance with modern recommendations and additional comparative analysis of lipid peroxidation rates (LPO), levels of C-reactive protein (CRP), lactate dehydrogenase (LDH), total nitrate and nitrite (NOx) in the peripheral blood and menstrual blood on day 2 of the menstrual cycle.
RESULTS
The LPO indexes in the examined groups were within identical limits and did not differ, except for an increased content of malondialdehyde (MDA), an increased value of the light sum S and a decreased value of the antioxidant activity tg2ά in the menstrual blood as a result of the LPO process activation and a decreased antioxidant defense system (AOSP) at a local level (in the menstrual blood) in women with infertility at chronic endometritis. The level of CRP did not exceed normal values in all groups, but was higher in menstrual blood in patients with chronic endometritis. The LDH content in menstrual blood was 10-fold higher than in the control group and 25-fold higher than in the patients with chronic endometritis. Total nitrates and nitrites NOx did not differ between the main and control groups but had significant differences in peripheral and menstrual blood within the studied groups.
CONCLUSION
Thus, in chronic endometritis in patients with infertility, biochemical parameters in the menstrual blood confirm the imbalance between LPO and AOSP, which requires adding agents to the traditional treatment regimen to control excessive lipoperoxidation.
