Diagnosis of early neonatal infections in premature newborns

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OBJECTIVE

To evaluate significance of risk factors, clinical and laboratory indicators in diagnosis of early neonatal infections in premature neonates.

MATERIAL AND METHODS

A prospective single-center observational study included 385 newborns between 2021 and 2022. Mean gestation period was 35 (33—39) weeks, birth weight — 2500 (1850—3350) g. All children were divided into two groups depending on intraamniotic infection (IAI): group I — IAI, group II — no IAI. All children underwent clinical, laboratory and bacteriological examination within an hour after admission. Negative results of bacteriological examination were registered in 274 (71.4%) children. Among infected cases, Staphylococcus epidermidis (50%) and Klebsiella pneumoniae (14.5%) were the most common.

RESULTS

WBC count and neutrophil index were similar in both groups. Significant prognostic factors of early neonatal infection are low birth weight (<2630 g), Apgar score <7 points in the first minute, anhydrous interval >9 hours and serum C-reactive protein >35 mg/l upon admission to ICU. Anhydrous interval >9 hours increases the risk of IAI by 2 times.

CONCLUSION

Analysis of risk factors depending on anhydrous interval and C-reactive protein allows identifying the newborns with high probability of early neonatal infection.

Keywords:

early neonatal infection

leukocytes

neutrophil index

C-reactive protein

newborns

Authors:

Ivanov D.O.

St. Petersburg State Pediatric Medical University

ORCID: 0000-0002-0060-4168

Aleksandrovich Yu.S.

St. Petersburg State Pediatric Medical University

ORCID: 0000-0002-2131-4813

Pavlovskaya E.Yu.

St. Petersburg State Pediatric Medical University;
St. Nicholas Children’s Hospital No. 17

ORCID: 0000-0001-9960-7141

Pshenisnov K.V.

St. Petersburg State Pediatric Medical University

ORCID: 0000-0003-1113-5296

Tikhova G.P.

Petrozavodsk State University

SPIN RSCI: 9186-9653
Scopus AuthorID: 6504623302
ORCID: 0000-0003-1128-9666

Zemlyanoy D.A.

St. Petersburg State Pediatric Medical University

ORCID: 0000-0003-4716-809X

Received:

11.01.2024

Accepted:

13.03.2024

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