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Ivanov D.O.

St. Petersburg State Pediatric Medical University

Aleksandrovich Yu.S.

Children’s Scientific Clinical Center for Infectious Diseases

Pavlovskaya E.Yu.

St. Petersburg State Pediatric Medical University;
St. Nicholas Children’s Hospital No. 17

Pshenisnov K.V.

Children’s Scientific Clinical Center for Infectious Diseases

Tikhova G.P.

Petrozavodsk State University

Zemlyanoy D.A.

St. Petersburg State Pediatric Medical University

Diagnosis of early neonatal infections in premature newborns

Authors:

Ivanov D.O., Aleksandrovich Yu.S., Pavlovskaya E.Yu., Pshenisnov K.V., Tikhova G.P., Zemlyanoy D.A.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2024;(4): 6‑13

DOI: 10.17116/anaesthesiology20240416

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Table of contents

DIAGNOSIS OF EARLY NEONATAL INFECTIONS IN PREMATURE NEWBORNS
DIAGNOSIS OF EARLY NEONATAL INFECTIONS IN PREMATURE NEWBORNS

To cite this article:

Ivanov DO, Aleksandrovich YuS, Pavlovskaya EYu, Pshenisnov KV, Tikhova GP, Zemlyanoy DA. Diagnosis of early neonatal infections in premature newborns. Russian Journal of Anesthesiology and Reanimatology. 2024;(4):6‑13. (In Russ.)
https://doi.org/10.17116/anaesthesiology20240416

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Abstract:

OBJECTIVE

To evaluate significance of risk factors, clinical and laboratory indicators in diagnosis of early neonatal infections in premature neonates.

MATERIAL AND METHODS

A prospective single-center observational study included 385 newborns between 2021 and 2022. Mean gestation period was 35 (33—39) weeks, birth weight — 2500 (1850—3350) g. All children were divided into two groups depending on intraamniotic infection (IAI): group I — IAI, group II — no IAI. All children underwent clinical, laboratory and bacteriological examination within an hour after admission. Negative results of bacteriological examination were registered in 274 (71.4%) children. Among infected cases, Staphylococcus epidermidis (50%) and Klebsiella pneumoniae (14.5%) were the most common.

RESULTS

WBC count and neutrophil index were similar in both groups. Significant prognostic factors of early neonatal infection are low birth weight (<2630 g), Apgar score <7 points in the first minute, anhydrous interval >9 hours and serum C-reactive protein >35 mg/l upon admission to ICU. Anhydrous interval >9 hours increases the risk of IAI by 2 times.

CONCLUSION

Analysis of risk factors depending on anhydrous interval and C-reactive protein allows identifying the newborns with high probability of early neonatal infection.

Keywords:

early neonatal infection
leukocytes
neutrophil index
C-reactive protein
newborns

Authors:

Ivanov D.O.

St. Petersburg State Pediatric Medical University

Aleksandrovich Yu.S.

Children’s Scientific Clinical Center for Infectious Diseases

Pavlovskaya E.Yu.

St. Petersburg State Pediatric Medical University;
St. Nicholas Children’s Hospital No. 17

Pshenisnov K.V.

Children’s Scientific Clinical Center for Infectious Diseases

Tikhova G.P.

Petrozavodsk State University

Zemlyanoy D.A.

St. Petersburg State Pediatric Medical University

Received:

11.01.2024

Accepted:

13.03.2024

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