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Ivanov D.O.
St. Petersburg State Pediatric Medical University
Pavlovskaya E.Yu.
St. Petersburg State Pediatric Medical University;
St. Nicholas Children’s Hospital No. 17
Tikhova G.P.
Petrozavodsk State University
Diagnosis of early neonatal infections in premature newborns
Journal: Russian Journal of Anesthesiology and Reanimatology. 2024;(4): 6‑13
Read: 1467 times
To cite this article:
Ivanov DO, Aleksandrovich YuS, Pavlovskaya EYu, Pshenisnov KV, Tikhova GP, Zemlyanoy DA. Diagnosis of early neonatal infections in premature newborns. Russian Journal of Anesthesiology and Reanimatology.
2024;(4):6‑13. (In Russ.)
https://doi.org/10.17116/anaesthesiology20240416
To evaluate significance of risk factors, clinical and laboratory indicators in diagnosis of early neonatal infections in premature neonates.
A prospective single-center observational study included 385 newborns between 2021 and 2022. Mean gestation period was 35 (33—39) weeks, birth weight — 2500 (1850—3350) g. All children were divided into two groups depending on intraamniotic infection (IAI): group I — IAI, group II — no IAI. All children underwent clinical, laboratory and bacteriological examination within an hour after admission. Negative results of bacteriological examination were registered in 274 (71.4%) children. Among infected cases, Staphylococcus epidermidis (50%) and Klebsiella pneumoniae (14.5%) were the most common.
WBC count and neutrophil index were similar in both groups. Significant prognostic factors of early neonatal infection are low birth weight (<2630 g), Apgar score <7 points in the first minute, anhydrous interval >9 hours and serum C-reactive protein >35 mg/l upon admission to ICU. Anhydrous interval >9 hours increases the risk of IAI by 2 times.
Analysis of risk factors depending on anhydrous interval and C-reactive protein allows identifying the newborns with high probability of early neonatal infection.
Authors:
Ivanov D.O.
St. Petersburg State Pediatric Medical University
Pavlovskaya E.Yu.
St. Petersburg State Pediatric Medical University;
St. Nicholas Children’s Hospital No. 17
Tikhova G.P.
Petrozavodsk State University
Received:
11.01.2024
Accepted:
13.03.2024
List of references:
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