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Mikhin V.P.

Kursk State Medical University

Kostina N.L.

Kursk State Medical University

Nikolenko T.A.

Kursk State Medical University

Savelyeva V.V.

Kursk State Medical University

Chernyatina M.A.

Kursk State Medical University

The possibilities of Mexidol in the complex therapy of arterial hypertension

Authors:

Mikhin V.P., Kostina N.L., Nikolenko T.A., Savelyeva V.V., Chernyatina M.A.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2024;17(5): 572‑580

DOI: 10.17116/kardio202417051572

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Table of contents

THE POSSIBILITIES OF MEXIDOL IN THE COMPLEX THERAPY OF ARTERIAL HYPERTENSION
THE POSSIBILITIES OF MEXIDOL IN THE COMPLEX THERAPY OF ARTERIAL HYPERTENSION

To cite this article:

Mikhin VP, Kostina NL, Nikolenko TA, Savelyeva VV, Chernyatina MA. The possibilities of Mexidol in the complex therapy of arterial hypertension. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;17(5):572‑580. (In Russ.)
https://doi.org/10.17116/kardio202417051572

Подписка 2025-2 (Russian Journal of Cardiology and Cardiovascular Surgery)
 
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A review of the literature is devoted to the effects of the ethylmethylhydroxypyridine succinate (mexidol) in patients with arterial hypertension. The analysis of 44 sources of Russian and foreign literature showed more effective achievement of the target values of blood pressure, prevention of severe complications in hypertensive crises in patients with mexidol therapy. The evidence of the positive effect of cytoprotective therapy on the condition of the left ventricle and vascular wall is considered. The results of large-scale studies demonstrating the effective correction of cognitive dysfunction of the brain using mexidol are presented. The role of the drug in stabilizing of biochemical processes, including lipid peroxidation, glucose and cholesterol metabolism, which determines the pleiotropic effects of mexidol in patients with hypertension, is emphasized.

Keywords:

arterial hypertension
vascular wall stiffness
lipid peroxidation
myocardial deremodelation
cognitive impairment

Authors:

Mikhin V.P.

Kursk State Medical University

Kostina N.L.

Kursk State Medical University

Nikolenko T.A.

Kursk State Medical University

Savelyeva V.V.

Kursk State Medical University

Chernyatina M.A.

Kursk State Medical University

Received:

03.07.2024

Accepted:

12.08.2024

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