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Golounina O.O.

I.M. Sechenov First Moscow State Medical University

Pavlova M.G.

I.M. Sechenov First Moscow State Medical University

Gronskaya S.A.

National Medical Research Center of Endocrinology

Kaznacheeva T.V.

Evdokimov Moscow State University of Medicine and Dentistry, Department of Reproductive Medicine and Surgery

Dzeranova L.K.

Endocrinology Research Centre

Belaya J.E.

National Medical Research Center of Endocrinology

Fadeev V.V.

Sechenov First Moscow State Medical University (Sechenov University)

Cushing’s syndrome and pregnancy: diagnostic, treatment and management tactics

Authors:

Golounina O.O., Pavlova M.G., Gronskaya S.A., Kaznacheeva T.V., Dzeranova L.K., Belaya J.E., Fadeev V.V.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2021;21(5): 5‑14

DOI: 10.17116/rosakush2021210515

Read: 3259 times

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Table of contents

CUSHING’S SYNDROME AND PREGNANCY: DIAGNOSTIC, TREATMENT AND MANAGEMENT TACTICS
CUSHING’S SYNDROME AND PREGNANCY: DIAGNOSTIC, TREATMENT AND MANAGEMENT TACTICS

To cite this article:

Golounina OO, Pavlova MG, Gronskaya SA, Kaznacheeva TV, Dzeranova LK, Belaya JE, Fadeev VV. Cushing’s syndrome and pregnancy: diagnostic, treatment and management tactics. Russian Bulletin of Obstetrician-Gynecologist. 2021;21(5):5‑14. (In Russ.)
https://doi.org/10.17116/rosakush2021210515

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Cushing’s syndrome (CS) in pregnancy is rare condition and needs to be thoroughly differentiated with physiological hypercortisolism caused by the activation of the hypothalamic-pituitary-adrenal axis and the endocrine placenta function. The factors of the disease are the following: a history of CS, the presence of several clinical manifestations of hypercortisolism from early pregnancy, a burdened obstetric history. In order to detect CS in pregnant woman the adequate and timely treatment and observation by endocrinologist, obstetrician-gynecologist, and cardiologist is required. However, CS is not an absolute indication for pregnancy termination, although in some cases this may be justified. At the same time, the active stage of the disease is associated with a significant risk of complications for mother and fetus both. In case of stable disease course, the periodic observation of the patient or symptomatic therapy prescription aimed at correcting the arterial hypertension, carbohydrate metabolism disorders and other complications is recommended. In case of progressive disease, it is possible to prescribe the short-term therapy with metirapone or ketoconazole to block very high cortisol production as preparatory stage for the surgery; also, it could be used if surgery is contraindicated. Delivery by caesarean section is recommended no later than 36-37 gestational weeks. The majority of children born to mothers in remission of CS turn out to be healthy.

Keywords:

endogenous hypercortisolism
cushing’s disease
cushing’s syndrome
pregnancy
childbirth
metyrapone
ketoconazole

Authors:

Golounina O.O.

I.M. Sechenov First Moscow State Medical University

Pavlova M.G.

I.M. Sechenov First Moscow State Medical University

Gronskaya S.A.

National Medical Research Center of Endocrinology

Kaznacheeva T.V.

Evdokimov Moscow State University of Medicine and Dentistry, Department of Reproductive Medicine and Surgery

Dzeranova L.K.

Endocrinology Research Centre

Belaya J.E.

National Medical Research Center of Endocrinology

Fadeev V.V.

Sechenov First Moscow State Medical University (Sechenov University)

Received:

02.02.2021

Accepted:

16.03.2021

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References:

  1. Belaya ZhE, Rozhinskaya LY, Dragunova NV, Dzeranova LK, Marova EI, Arapova SD, Molitvoslovova NN, Zenkova TS, Mel’nichenko GA, Dedov II. Metabolic complications of endogenous Cushing: patient selection for screening. Ozhirenie i metabolizm. 2013;10:1:26-31. (In Russ.). https://doi.org/10.14341/2071-8713-5068
  2. Caimari F, Valassi E, Garbayo P, Steffensen C, Santos A, Corcoy R, Webb SM. Cushing’s syndrome and pregnancy outcomes: a systematic review of published cases. Endocrine. 2017;55:2:555-563.  https://doi.org/10.1007/s12020-016-1117-0
  3. Mel’nichenko GA, Dedov II, Belaya ZhE, Rozhinskaya LY, Vagapova GR, Volkova NI, Grigor’ev AY, Grineva EN, Marova EI, Mkrtumayn A., Trunin YuYu, Cherebillo VYu. Cushing’s disease: the clinical features, diagnostics, differential diagnostics, and methods of treatment. Problemy endokrinologii (Mosk). 2015;61:2:55-77. (In Russ.). https://doi.org/10.14341/probl201561255-77
  4. Lindsay JR, Nieman LK. The Hypothalamic-pituitary-adrenal axis in pregnancy: challenges in disease detection and treatment. Endocrine Rev. 2005;26:6:775-799.  https://doi.org/10.1210/er.2004-0025
  5. Lim WH, Torpy DJ, Jeffries WS. The medical management of Cushing’s syndrome during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2013;168:1:1-6.  https://doi.org/10.1016/j.ejogrb.2012.12.015
  6. Pourali L, Vatanchi AM, Hamidi A. A Case of Cushing’s syndrome in pregnancy. Iran J Med Sci. 2017;42:6:607-610. 
  7. Kita M, Sakalidou M, Saratzis A, Ioannis S, Avramidis A. Cushing’s syndrome in pregnancy: report of a case and review of the literature. Hormones (Athens). 2007;6:3:242-246. 
  8. Zieleniewski W, Michalak R. A successful case of pregnancy in a woman with ACTH-independent Cushing’s syndrome treated with ketoconazole and metyrapone. Gynecol Endocrinol. 2017;33:5:349-352.  https://doi.org/10.1080/09513590.2017.1290070
  9. Andreescu CE, Alwani RA, Hofland J, Looijenga LHJ., de Herder WW, Hofland LJ, Feelders RA. Adrenal Cushing’s syndrome during pregnancy. Eur J Endocrinol. 2017;177:5:13-20.  https://doi.org/10.1530/EJE-17-0263
  10. Wang W, Yuan F, Xu D. Cushing’s syndrome during pregnancy caused by adrenal cortical adenoma: a case report and literature review. Front Med. 2015;9:3:380-383.  https://doi.org/10.1007/s11684-015-0407-x
  11. Serón-Ferré M, Richter HG, Valenzuela GJ, Torres-Farfan C. Circadian rhythms in the fetus and newborn: Significance of interactions with maternal physiology and the environment. Prenatal and Postnatal Determinants of Development. 2016;147-165. 
  12. Chatuphonprasert W, Jarukamjorn K, Ellinger I. Physiology and pathophysiology of steroid biosynthesis, transport and metabolism in the human placenta. Front Pharmacol. 2018;9:1027. https://doi.org/10.3389/fphar.2018.01027
  13. Sandman CA. Prenatal CRH: An integrating signal of fetal distress. Dev Psychopathol. 2018;30:3:941-952.  https://doi.org/10.1017/S0954579418000664
  14. Solano ME, Arck PC. Steroids, Pregnancy and Fetal Development. Front Immunol. 2019;10:3017. https://doi.org/10.3389/fimmu.2019.03017
  15. Bates K, Herzog ED. Maternal-fetal circadian communication during pregnancy. Front Endocrinol (Lausanne). 2020;11:198.  https://doi.org/10.3389/fendo.2020.00198
  16. Kazma JM, van den Anker J, Allegaert K, Dallmann A, Ahmadzia HK. Anatomical and physiological alterations of pregnancy. J Pharmacokinet Pharmacodyn. 2020;47:4:271-285.  https://doi.org/10.1007/s10928-020-09677-1
  17. Gore AC. Prenatal Programming and Endocrinology. Endocrinology. 2015;156:10:3403-3404. https://doi.org/10.1210/en.2015-1671
  18. Simister N. Placental transport of immunoglobulin G. Vaccine. 2003;21:24:3365-3369. https://doi.org/10.1016/S0264-410X(03)00334-7
  19. Salvante KG, Milano K, Kliman HJ, Nepomnaschy PA. Placental 11 β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) expression very early during human pregnancy. J Dev Orig Health Dis. 2017;8:2:149-154.  https://doi.org/10.1017/S2040174416000611
  20. Zhu P, Wang W, Zuo R, Sun K. Mechanisms for establishment of the placental glucocorticoid barrier, a guard for life. Cell Mol Life Sci. 2019;76:1:13-26.  https://doi.org/10.1007/s00018-018-2918-5
  21. Waffarn F, Davis EP. Effects of antenatal corticosteroids on the hypothalamic-pituitary-adrenocortical axis of the fetus and newborn: experimental findings and clinical considerations. Am J Obstet Gynecol. 2012;207:6:446-454.  https://doi.org/10.1016/j.ajog.2012.06.012
  22. Lacroix A, Feelders RA, Stratakis CA, Nieman LK. Cushing’s syndrome. The Lancet. 2015;386:9996:913-927.  https://doi.org/10.1016/S0140-6736(14)61375-1
  23. Feelders R, Sharma S, Nieman L. Cushing’s syndrome: epidemiology and developments in disease management. CLEP. 2015:281.  https://doi.org/10.2147/CLEP.S44336
  24. Vilar L, Freitas M da C, Lima LHC, Lyra R, Kater CE. Cushing’s syndrome in pregnancy: an overview. Arq Bras Endocrinol Metabol. 2007;51:8:1293-1302.
  25. Nassi R, Ladu C, Vezzosi C, Mannelli M. Cushing’s syndrome in pregnancy. Gynecol Endocrinol. 2015;31:2:102-104.  https://doi.org/10.3109/09513590.2014.984680
  26. Dogansen S. Uncomplicated pregnancy in a patient with Cushing’s disease. Acta Endo (Buc). 2017;13:2:215-219.  https://doi.org/10.4183/aeb.2017.215
  27. St-Jean M, MacKenzie-Feder J, Bourdeau I, Lacroix A. Exacerbation of Cushing’s syndrome during pregnancy: stimulation of a cortisol-secreting adrenocortical adenoma by ACTH originating from the foeto-placental unit. Endocrinol Diabetes Metab Case Rep. 2019;2019: 18-0115. https://doi.org/10.1530/EDM-18-0115
  28. Touiti A, Mghari GE, Ansari NE. Syndrome de Cushing pendant la grossesse: à propos d’un cas d’adénome surrénalien. Pan Afr Med J. 2015;21:79-90.  https://doi.org/10.11604/pamj.2015.21.81.6775
  29. Lindsay JR, Jonklaas J, Oldfield EH, Nieman LK. Cushing’s Syndrome during pregnancy: Personal experience and review of the literature. J Clinl Endocrinol Metab. 2005;90:5:3077-3083. https://doi.org/10.1210/jc.2004-2361
  30. Achong N, D’Emden M, Fagermo N, Mortimer R. Pregnancy-induced Cushing’s syndrome in recurrent pregnancies: Case report and literature review: Pregnancy-induced Cushing’s syndrome. Australian New Zealand J Obstet Gynaecol. 2012;52:1:96-100.  https://doi.org/10.1111/j.1479-828X.2011.01388.x
  31. Kasperlik-Zaluska AA, Szczupacka I, Leszczynska-Bystrzanowska J, Drus-Przybyszewska G. Pregnancy-dependent Cushing’s syndrome in three pregnancies. BJOG:An International Journal of O&G. 2000;107:6:810-812.  https://doi.org/10.1111/j.1471-0528.2000.tb13348.x
  32. Xu J, Wang Y, Shan L, Gu W., Zeng W. Recurrent ACTH-independent Cushing’s syndrome in multiple pregnancies. Gynecoll Endocrinol. 2013;29:4:309-310.  https://doi.org/10.3109/09513590.2012.743014
  33. Gronskaya SA, Belaya ZhE, Mel’nichenko GA, Dzeranova LK, Pigarova EA, Ponomareva TA. The pregnancy and delivery in patients with Cushing’s disease. Problemy reproduktsii. 2016;22:6:110-114. (In Russ.). https://doi.org/10.17116/repro2016226110-114
  34. Repina MA. Hypercortisolism and pregnancy. Zhurnal akusherstva i zhenskikh boleznei. 2017;66:3:116-123. (In Russ.). https://doi.org/10.17816/JOWD663116-123
  35. Bronstein MD, Machado MC, Fragoso MCBV. MANAGEMENT OF ENDOCRINE DISEASE: Management of pregnant patients with Cushing’s syndrome. Eur J Endocrinol. 2015;173:2:85-91.  https://doi.org/10.1530/EJE-14-1130
  36. Dong D, Li H, Xiao H. The diagnosis and management of Cushing syndrome during pregnancy. J Obstetr Gynaecol. 2015;35:1:94-96.  https://doi.org/10.3109/01443615.2014.937331
  37. Gordyunina SV. Insulin resistance during pregnancy (a literature review). Problemy endokrinologii (Mosk). 2013;59:5:61-66. (In Russ.). https://doi.org/10.14341/probl201359561-66
  38. Seraphim APCG, Chiba FY, Pereira RF, Mattera MS de LC, Moimaz SAS, Sumida DH. Relationship among periodontal disease, insulin resistance, salivary cortisol, and stress levels during pregnancy. Braz Dent J. 2016;27:2:123-127.  https://doi.org/10.1590/0103-6440201600596
  39. Machado MC, Fragoso MCBV, Bronstein MD. Pregnancy in Patients with Cushing’s Syndrome. Endocrinol Metab Clin North Am. 2018;47(2):441-449.  https://doi.org/10.1016/j.ecl.2018.02.004
  40. Brue T, Amodru V, Castinetti F. MANAGEMENT OF ENDOCRINE DISEASE: Management of Cushing’s syndrome during pregnancy: solved and unsolved questions. Eur JEndocrinoly. 2018;178:6:259-266.  https://doi.org/10.1530/EJE-17-1058
  41. Jung C, Ho JT, Torpy DJ, Rogers A, Doogue M, Lewis JG, Czajko RJ, Inder WJ. A Longitudinal Study of Plasma and Urinary Cortisol in Pregnancy and Postpartum. J Clinl Endocrinol Metab. 2011;96:5:1533-1540. https://doi.org/10.1210/jc.2010-2395
  42. Nieman LK, Biller BMK, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM. The Diagnosis of Cushing’s syndrome: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2008;93:5:1526-1540. https://doi.org/10.1210/jc.2008-0125
  43. Belaya ZhE, Il’in AV, Mel’nichenko GA, Rozhinskaya LY, Dragunova NV, Dzeranova LK, Ogneva NA, Butrova SA, Troshina EA, Kolesnikova GS, Dedov II. Avtomatizirovannyy elektrokhemilyuminestsentnyy metod opredeleniya kortizola v slyune dlya diagnostiki endogennogo giperkortitsizma sredi patsientov s ozhireniem. Ozhirenie i metabolism. 2011;8:2:56-63. (In Russ.). https://doi.org/10.14341/2071-8713-4954
  44. Elias PCL, Martinez EZ, Barone BFC, Mermejo LM, Castro M, Moreira AC. Late-night salivary cortisol Has a better performance than urinary free cortisol in the diagnosis of Cushing’s syndrome. J Clin Endocrinol Metab. 2014;99:6:2045-2051. https://doi.org/10.1210/jc.2013-4262
  45. Lopes LML, Francisco RPV, Galletta MAK, Bronstein MD. Determination of nighttime salivary cortisol during pregnancy: comparison with values in non-pregnancy and Cushing’s disease. Pituitary. 2016;19:1:30-38.  https://doi.org/10.1007/s11102-015-0680-3
  46. Jeyaraman K, Ammini AC, Nandita G, Dwivedi SN. Late-night salivary cortisol in normal subjects and in patients with Cushing’s syndrome. Postgraduate Med J. 2010;86:1017:399-404.  https://doi.org/10.1136/pgmj.2009.090787
  47. Yaneva M, Kirilov G, Zacharieva S. Midnight salivary cortisol, measured by highly sensitive influence of gender difference. Arch Phys Med Rehabill. 2011;92:1987-1991.
  48. Belaya ZE, Iljin AV, Melnichenko GA, Rozhinskaya LY, Dragunova NV, Dzeranova LK, Butrova SA, Troshina EA, Dedov II. Diagnostic performance of late-night salivary cortisol measured by automated electrochemiluminescence immunoassay in obese and overweight patients referred to exclude Cushing’s syndrome. Endocrine. 2012;41:3:494-500.  https://doi.org/10.1007/s12020-012-9658-3
  49. Ray JG, Vermeulen MJ, Bharatha A, Montanera WJ., Park AL. Association between MRI exposure during pregnancy and fetal and childhood outcomes. JAMA. 2016;316:9:952.  https://doi.org/10.1001/jama.2016.12126
  50. Woodmansee WW. Pituitary disorders in pregnancy. Neurol Clin. 2019;37:1:63-83.  https://doi.org/10.1016/j.ncl.2018.09.009
  51. Tang K, Lu L, Feng M, Zhang H, Chen K, Sun X, Zhu H, Wang R, Lu Z. The incidence of pregnancy-associated Cushing’s disease and its relation to pregnancy: a retrospective study. Front Endocrinol (Lausanne). 2020;11:305.  https://doi.org/10.3389/fendo.2020.00305
  52. Abbassy M, Kshettry V, Hamrahian A, Johnston P, Dobri G, Avitsian R, Woodard T, Recinos P. Surgical management of recurrent Cushing′s disease in pregnancy: A case report. Surg Neurol Int. 2015;26:6:640.  https://doi.org/10.4103/2152-7806.170472
  53. Katulski K, Podfigurna-Stopa A, Maciejewska-Jeske M, Ruchala M, Gurgul E, Szymankiewicz M, Breborowicz GH, Karmelita-Katulska K, Stajgis M, Biczysko M. Cushing’s syndrome in pregnancy: a case report and mini review of the literature. Gynecol Endocrinol. 2014;30:5:345-349.  https://doi.org/10.3109/09513590.2013.879857
  54. Sammour RN, Saiegh L, Matter I, Gonen R, Shechner C, Cohen M, Ohel G, Dickstein G. Adrenalectomy for adrenocortical adenoma causing Cushing’s syndrome in pregnancy: a case report and review of literature. Eur J Obstet Gynecol Reprod Biol. 2012;165:1:1-7.  https://doi.org/10.1016/j.ejogrb.2012.05.030
  55. Martínez García R, Martínez Pérez A, Domingo del Pozo C, Sospedra Ferrer R. Cushing’s syndrome in pregnancy. Laparoscopic adrenalectomy during pregnancy: the mainstay treatment. J Endocrinol Invest. 2016;39:3:273-276.  https://doi.org/10.1007/s40618-015-0345-0
  56. Pricolo VE, Monchik JM, Prinz RA, DeJong S., Chadwick DA., Lamberton RP. Management of Cushing’s syndrome secondary to adrenal adenoma during pregnancy. Surgery. 1990;108:6:1077-1078.
  57. Jornayvaz FR, Assie G, Bienvenu-Perrard M, Coste J, Guignat L., Bertherat J, Silvera S, Bertagna X, Legmann P. Pregnancy does not accelerate corticotroph tumor progression in nelson’s syndrome. J Clin Endocrinol Metab. 2011;96:4:658-662.  https://doi.org/10.1210/jc.2010-2235
  58. Close CF, Mann MC, Watts JF, Taylor KG. ACTH-independent Cushing’s syndrome in pregnancy with spontaneous resolution after delivery: control of the hypercortisolism with metyrapone.: Case report. Clin Endocrinol. 1993;39:3:375-379.  https://doi.org/10.1111/j.1365-2265.1993.tb02380.x
  59. Aron DC, Schnall AM, Sheeler LR. Spontaneous resolution of Cushing’s syndrome after pregnancy. Am J Obstet Gynecol. 1990;162:2:472-474.  https://doi.org/10.1016/0002-9378(90)90413-2
  60. Hana V, Dokoupilova M, Marek J, Plavka R. Recurrent ACTH-independent Cushing’s syndrome in multiple pregnancies and its treatment with metyrapone. Clin Endocrinol. 2001;54:2:277-281.  https://doi.org/10.1046/j.1365-2265.2001.01055.x
  61. Berwaerts J, Verhelst J, Mahler C, Abs R. Cushing’s syndrome in pregnancy treated by ketoconazole: Case report and review of the literature. Gynecol Endocrinol. 1999;13:3:175-182.  https://doi.org/10.3109/09513599909167552
  62. Boronat M. Marrero D, López-Plasencia Y, Barber M, Schamann Y, Nóvoa FJ. Successful outcome of pregnancy in a patient with Cushing’s disease under treatment with ketoconazole during the first trimester of gestation. Gynecol Endocrinol. 2011;27:9:675-677.  https://doi.org/10.3109/09513590.2010.521268
  63. Lindsay JR, Nieman LK. Adrenal Disorders in Pregnancy. Endocrinol Metabol Clin North Am. 2006;35:1:1-20.  https://doi.org/10.1016/j.ecl.2005.09.010
  64. Costenaro F, Rodrigues TC, de Lima PB, Ruszczyk J, Rollin G, Czepielewski MA. A successful case of Cushing’s disease pregnancy treated with ketoconazole. Gynecol Endocrinol. 2015;31:3:176-178.  https://doi.org/10.3109/09513590.2014.995615
  65. Woo I, Ehsanipoor RM. Cabergoline therapy for Cushing disease throughout pregnancy. Obstet Gynecol. 2013;122:2:485-487.  https://doi.org/10.1097/AOG.0b013e31829e398a
  66. Nakhleh A, Saiegh L, Reut M, Ahmad MS, Wirsansky Pearl I, Shechner C. Cabergoline treatment for recurrent Cushing’s disease during pregnancy. HJ. 2016;15:3:453-458.  https://doi.org/10.14310/horm.2002.1685
  67. Sek KS-Y, Deepak DS, Lee KO. Use of cabergoline for the management of persistent Cushing’s disease in pregnancy. BMJ Case Reports. 2017;bcr-2016-217855. https://doi.org/10.1136/bcr-2016-217855
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