Superficial skin mycoses are the most common human’s fungal diseases. Their therapy by systemic and local antifungal drugs is effective in most cases. In recent times, the number of cases of ineffective application of antifungal drugs in regimen recommended by clinical guidelines and medicines’ instructions increased. Prescription of therapy schemes involving simultaneous use of several antifungal drugs allows overcoming low effectiveness of antifungal monotherapy. The number of clinical cases of superficial skin mycoses equal 2 was described: malassezia folliculitis (causative agent — Malassezia sympodialis) and disseminated microsporidiosis (causative agent — Microsporum canis), that at first were poorly responded to antifungal therapy, but eventually were completely cured. Malassezia folliculitis in 18-years-old patient, who took 60 mg/day prednisolone calculated as 1 mg/kg/day and 100 mg/day azathioprine due to pyoderma gangrenosum, was cured by combination of solution with 2% sertaconazole and shampoo with 2% ketoconazole and 1% zinc pyrithione. Moreover, after recovery, further use of shampoo with 2% ketoconazole and 1% zinc pyrithione in a preventive treatment regimen, namely 1—2 times per week, while remaining immunosuppressive state associated with the treatment of pyoderma gangrenosum allowed to predict Malassezia folliculitis recurrence. The combination of griseofulvin application, ingested at a dose of 750 mg/day calculated as 22 mg/kg/day, and local therapy by solution with sertaconazole and shampoo with ketoconazole and zinc pyrithione, was effective in disseminated microsporidiosis of smooth skin with damage of lanugo. Combined therapy with the use of medical antifungal two-component shampoo allowed to increase the treatment effectiveness, accelerate patients’ recovery, prevent the distribution of mycotic infection during washing, and the use of antifungal shampoo in a preventive regimen, namely 1—2 times per week, when long-term immunosuppression — to prevent the recurrence of malassezia-folliculitis.