The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Mel'nikov A.P.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Akhvlediani K.N.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Poddelkova A.Yu.

State Budgetary Healthcare Institution of the Moscow Region Moscow Regional Scientific Research Institute of Obstetrics and Gynecology, Moscow, Russia

Thrombotic microangiopathic hemolytic anemia and complications during pregnancy. To aid the practitioner

Authors:

Mel'nikov A.P., Akhvlediani K.N., Poddelkova A.Yu.

More about the authors

Read: 4030 times


To cite this article:

Mel'nikov AP, Akhvlediani KN, Poddelkova AYu. Thrombotic microangiopathic hemolytic anemia and complications during pregnancy. To aid the practitioner. Russian Bulletin of Obstetrician-Gynecologist. 2019;19(5):92‑98. (In Russ.)
https://doi.org/10.17116/rosakush20191905192

Recommended articles:
On mole­cular gene­tic predictors of preeclampsia. Russian Bulletin of Obstetrician-Gynecologist. 2024;(6):26-34
The level of hypo­xia-induced factor-1a and asso­ciated mole­cules in preeclampsia. Russian Bulletin of Obstetrician-Gynecologist. 2025;(1):5-10
Fibrin mono­mer in diagnosis of cardiovascular diseases. Russian Cardiology Bulletin. 2024;(4-2):113-120
Central nervous system invo­lvement in systemic lupus erythematosus. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(2):124-129
Masks of autoimmune diseases: a multidisciplinary approach to the problem. Journal of Respiratory Medi­cine. 2025;(1):58-64

References:

  1. Makarov OV, Kozlov PV, Kuznetsov PA, Kopylova YuV, Vinokurova IN, Dzhokhadze LS, Osmanova AP. The role of disbalance of the vascular growth factors in development of the complications of pregnancy. Vestnik RSMU. 2014;5:34-37. (In Russ.)
  2. Scully M, O’Brien P. Thrombotic thrombocytopenic purpura and other microangiopathies. Eds. Pavord S, Hunt B. The Obstetric Hematology Manual Cambridge University Press. Cambridge. 2010;216:218-226. https://doi.org/10.1017/cbo9780511676451.022
  3. Krasnopol’skii VI, Shifman EM, Kulikov AV, Kozlovskaya NL, Artymuk NV, Belokrinitskaya TE, Gur’eva VM, Upryamova EYu, Smirnov GA, Stepanyuk VA, Matkovskiy AA. Report about carring out of the experts forum «Thrombotic microangiopathies and atypical hemolytic-uremic syndrome in obstetrics. The first step to wards multidisciplinary consensus». Rossiiskii vestnik akushera-ginekologa. 2017;17:1:96-103. (In Russ.) https://doi.org/10.17116/rosakush2017171118-125
  4. Regal JF, Burwick RM, Fleming SD. The Complement system and preeclampsia. Curr Hypertens Rep. 2017;19:11:87. https://doi.org/10.1007/s11906-017-0784-4
  5. Sidorova IS, Nikitina NA. Preeclampsia as a centre of consideration of the practicing physician. Obstetrics and gynecology. 2016;6:4-9. (In Russ.) https://doi.org/10.1038/s41581-019-0156-1
  6. Torchinov AM, Tsakhilova SG, Sarakhova DKh, Dzhonboboeva GN. Actual role of preeclampsia (gestosis) in modern obstetrics. Problems and decisions (review of the literature). Reproduction problems. 2010;3:87-91. (In Russ.)
  7. Mannucci PM. Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome: much progress and many remaining issues. Haematologicathe Hematology J. 2018;92:878-880. https://doi.org/10.3324/haematol.11196
  8. Meri S. Complement activation in diseases presenting with thrombotic microangiopathy. Eur J Intern Med. 2018;24:6:496-502. https://doi.org/10.1016/j.ejim.2013.05.009
  9. McMinn JR, George JN. Evaluation of women with clinically suspected thrombotic thrombocytopenic purpura-hemolytic uremic syndrome during pregnancy. J Clin Apher. 2017;16:202-209. https://doi.org/10.1002/jca.10005
  10. Owens MY, Martin JNJr, Wallace K, Keiser SD, Parrish MR, Tam Tam KB. Postpartum thrombotic microangiopathic syndrome. Transfus Apher Sci. 2016;48:1:51-57. https://doi.org/10.1016/j.transci.2012.05.016
  11. Furlan M, Roble SR, Lämmle B. Deficit ADAMTS13, activity of von Willebrand factor-cleaving protease in chronic relapsing thrombotic thrombocytopenic purpura. Blood. 2016;89:9:3097-3103. https://doi.org/10.1007/978-3-319-08717-7_1
  12. Mannucci PM, Canciani MT, Forza I. Changes in health and disease of the metalloprotease that cleaves von Willebrand factor. Blood. 2016;98:2730-2735. https://doi.org/10.1182/blood.v98.9.2730
  13. Moake JL, Rudy CK, Troll JH. Unusually large plasma factor VIII: von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura. N Engl J Med. 2018;307:1432-1435. https://doi.org/10.1016/s0338-4535(83)80059-2
  14. Tsai HM, Lian EC. Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura. N Engl J Med. 2017;339:22:1585-1494. https://doi.org/10.1056/nejm199811263392203
  15. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature. 2001;413:6855:488-494. https://doi.org/10.1038/35097008
  16. Sadler JE, Poncz M. Idiopathic thrombotic thrombocytopenic purpura/ Ch. 124. Antibody-mediated thrombotic disorders: idiopathic thrombotic thrombocytopenic purpura and heparin-induced thrombocytopenia. Williams Hematology, McGraw-Hill Medical. 2010:2031-2054. https://doi.org/10.1007/springerreference_110020
  17. Tsai HM. Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome. Am J Med. 2017; 126:3:200-209. https://doi.org/10.1016/j.amjmed.2012.09.006
  18. Zheng XL, Sadler JE. Pathogenesis of thrombotic microangiopathies. Ann Rev Pathol. 2018;3:249-277. https://doi.org/10.1146/annurev.pathmechdis.3.121806.154311
  19. Fakhouri F, Fremeaux-Bacchi V. Does hemolytic uremic syndrome differ from thrombotic thrombocytopenic purpura. Nat Clin Pract Nephrol. 2017;3:679-687. https://doi.org/10.1038/ncpneph0670
  20. Noris M, Giuseppe R. Atypical hemolytic-uremic syndrome. N Engl J Med. 2018;361:1676-1687. https://doi.org/10.1056/nejmra0902814
  21. Tsai HM. A Mechanistic approach to the diagnosis and management of atypical hemolytic uremic syndrome. Transfus Med Rev. 2018;28:4:187-197. https://doi.org/10.1016/j.tmrv.2014.08.004
  22. Fakhouri F, Roumenina L, Provot F, Sallée M, Caillard S, Couzi L. Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations. J Am Soc Nephrol. 2017;21:859-867. https://doi.org/10.1681/asn.2009070706
  23. Tsai HM, Kuo E. From Gestational hypertension and preeclampsia to atypical hemolytic uremic syndrome. Obstet Gynecol. 2016; 127:5:907-910. https://doi.org/10.1097/aog.0000000000001340
  24. Loirat C, Garnier A, Sellier-Leclerc AL, Kwon T. Plasmatherapy in atypical hemolytic uremic syndrome. Semin Thromb Hemost. 2018;36:673-681. https://doi.org/10.1055/s-0030-1262890
  25. Kozlovskaya NL, Merkusheva LI, Kirsanova TV, Runikhina NK. Peculiarities of the course and final of atypical hemolytic-uremic syndrome during pregnancy. Klinicheskaya nefrologiya. 2012;3:44-49. (In Russ.)
  26. Komlichenko EV, Govorov IE, Pervunina TM, Yakubov AV, Malushko AV, Komlichenko EE, Zhelonkina ED. Experience in managing a patient with atypical hemolytic-uremic syndrome. Lechenie i profilaktika. 2018;8:4:56-60. (In Russ.)
  27. Gavriilaki E, Yuan X, Ye Z, Ambinder AJ, Shanbhag SP, Streiff MB, Kickler TS, Moliterno AR, Sperati CJ, Brodsky RA. Modified Ham test for atypical hemolytic uremic syndrome. Blood. 2015;125:23:3637-3645. https://doi.org/10.1182/blood-2015-02-629683
  28. Fakhouri F, Vercel C, Fremeaux-Bacchi V. Obstetric nephrology: AKI and thrombotic microangiopathies in pregnancy. Clin J Am Soc Nephrol. 2015;7:12:2100-2106. https://doi.org/10.2215/cjn.13121211
  29. Sadler JE. Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura. Blood. 2018;112:11-18. https://doi.org/10.1182/blood-2008-02-078170
  30. Obstetrics: National manual. Eds. Savel’eva GM, Sukhikh GT, Serov VN, Radzinskiy VE. Moscow: GEOTAR-Media, 2018;1080. (In Russ.)

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.