Fibrin monomer in diagnosis of cardiovascular diseases

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This review discusses current issues of fibrin monomer as a marker for diagnosing cardiovascular diseases. The authors analyzed available literature data on the feasibility of fibrin monomer for assessing the risks of thrombotic complications, their severity and pre-thrombotic conditions. In the context of various cardiovascular diseases, fibrin monomer concentration allows identifying early stages of DIC syndrome and assessing its severity, differentiating the type of strokes (embolic or not), assessing the risks of postoperative deep vein thrombosis and thromboembolic complications. The shortcomings of current methods for analysis of fibrin monomer (insufficient standardization and no universal threshold values) are also considered. The authors analyze the prospects for further development of more advanced methods for analysis of fibrin monomer concentrations and their subsequent introduction into clinical practice.

Keywords:

fibrin monomer

myocardial infarction

stroke

atrial fibrillation

pulmonary embolism

deep vein thrombosis

disseminated intravascular coagulation

Authors:

Guria K.G.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0001-9475-0715

Avtaeva Y.N.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-3701-9747

Melnikov I.S.

Chazov National Medical Research Center of Cardiology;
Institute of Biomedical Problems

ORCID: 0000-0001-5241-3091

Vdovin V.M.

National Medical Research Center of Hematology

ORCID: 0000-0002-4606-3627

Momot A.P.

National Medical Research Center of Hematology

ORCID: 0000-0002-8413-5484

Saburova O.S.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-5702-9037

Shtelmakh V.E.

Chazov National Medical Research Center of Cardiology

ORCID: 0009-0002-2625-5354

Kozlov S.G.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0001-8800-1670

Okhota S.D.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-0744-8188

Prokofieva L.V.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-0230-2489

Gabbasov Z.A.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0003-3878-2573

Received:

11.11.2024

Accepted:

20.11.2024

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