Objective — to analyze a 10-year experience with the treatment and delivery of pregnant women with lower extremity vein thrombosis in order to assess the choice of treatment policy. Subject and methods. The paper presents the results of examination and treatment and the outcome of pregnancy in 96 women with lower extremity vein thrombosis. The patients were divided into 3 groups according to the pregnancy trimester in which the disease occurred: 1) (n=24, 25%) in the first trimester; 2) (n=26, 27%) in the second trimester; 3) (n=46, 47.9%) in the third trimester. In addition to traditional clinical and laboratory studies, a set of examinations included follow-up duplex ultrasound angioscanning of the lower extremity veins, hemostastic system study, D-dimer determination, and fetal monitoring (cardiotocography, Doppler ultrasound). Results. Lower extremity vein thrombosis more often developed in 46 (47.9%) pregnant women in the third trimester, which makes it possible to characterize this period as most thrombus-dangerous. The performed medical therapy for nonembologenic lower extremity superficial and deep vein thrombosis that developed in the first and second trimesters of pregnancy was highly effective and could timely perform vaginal delivery in most pregnant women in these groups. Nine pregnant women (in the first and second trimesters) underwent crossectomy; 15 (in the second and third trimesters) had plication of the deep femoral vein proximal to the site of a floating thrombus. Most of the patients in Group 3, including all pregnant women with deep vein thrombosis that developed at the end of the third trimester, delivered abdominally. There were no cases of massive blood loss and perinatal mortality. Conclusion. The choice of treatment policy for lower extremity vein thrombosis in pregnant women depends not only on the nature of thrombosis, its location, the degree of activity of the thrombotic process, and the presence of complications, but also on the timing of pregnancy and the status of a fetus. In the cases where a comprehensive examination has been established that there is no risk for life-threatening complications and that the status of a viable fetus is stable, their treatment should be medical, the main component of which is heparin therapy. The delivery method is chosen individually, by taking into account both the time of development and the nature of the venous pathology and the obstetric situation.