Objective — to assess the results of a comprehensive examination of reproductive-aged and premenopausal women with adenomyosis, by applying noninvasive methods. Subject and methods. The investigation included 59 patients (mean age, 40.5±6.2 years) (a study group) with adenomyosis verified in 42 (71.2%) cases and/or established according to magnetic resonance imaging and ultrasonography without concurrent uterine myoma. A control group consisted of 20 apparently healthy women of the same age. The investigators used traditional examinations, 3D-sonography, Doppler study of uterine vessels, magnetic resonance imaging, hysteroscopy and endomyometrial biopsy; histological examination. Results. Anamnestic and instrumental data were analyzed. There was a considerable proportion of adenomyosis patients aged younger than 35 (28.8%) years, nulliparous (25.4%) and infertile (19.1%) patients, and patients with a surgical history associated with peritoneal endometriosis (11.9%) and uterus operations (28.8%). In the patients with adenomyosis, the uterine volume (103.35±13.01 cm3) exceeded that in the control group (42.4±2.96 cm3) (p=0.001) (83.1%); myometrial asymmetry amounted to 7.01±8.12 mm (47.6%); the maximum junctional zone (JZmax) thickness of ≥12 mm was observed in 62.5% of the patients, but the irregular JZ thickening was <12 mm in one-third of cases. There was an increase in the IR of the uterine radial and basal arteries and decreases in vascularization index (VI), flow index (FI), and vascularization flow index (VFI) as compared with those in the control group (p<0.05). Conclusion. The paper shows the prevalence of magnetic resonance imaging and ultrasound signs in patients with isolated adenomyosis, including those in its histological verification. The need for clinical interpretation of the results of non-invasive examinations allows the diagnostic capabilities for adenomyosis to be improved in order to perform pathogenetic therapy, which is most important for patients with unrealized reproductive function.