Objective: to determine the clinical efficacy and safety of dosed estrogial cream in the therapy of patients with complaints of itching, dryness, and discomfort in the vulva and vagina as manifestations of their dystrophy and atrophy. Subjects and methods. Forty patients 40 patients aged 36 to 57 years with complaints of vaginal and vulvar itching, dryness, and discomfort were examined. The exclusion criteria were pregnancy, lactation, and primarily sexually transmitted infections. The degree of vulvar and vaginal itching and dryness was studied using a visual analog scale. Vaginal pH was determined in all the patients. Estrogial was administered intravaginally once daily according to the designed scheme. The efficiency of treatment was evaluated on 10, 20, 45, and 60 days after its initiation. Results. Estradiol was found to have a beneficial effect on the restoration of physiological function of the vaginal and vulvar epithelium, which indicates that most patients have normal vaginal microbiocenosis after treatment. Conclusion. Estrogial is characterized by good tolerability and safety, which enables its wide use in the treatment of patients with urogenital disorders in the presence of estrogen deficiency and complaints of vaginal and vulvar itching and dryness.