Objective — to investigate the features of the development of placental insufficiency (PI) in pregnant women after in vitro fertilization (IVF) and embryo transfer (ET) in some types of infertility. Subject and methods. A total of 120 women with singleton pregnancy underwent ultrasound and laboratory evaluation of the indicators of placental system function. Group 1 consisted of 72 pregnant women after IVF and ET; Group 2 (a control group) included 48 patients with spontaneous pregnancy. Group 1 was divided into 3 subgroups: 1A) 35 pregnant women with a history of tuboperitoneal infertility; 1B) 19 pregnant women with the endocrine form of infertility; 1C) 18 pregnant women with male factor infertility. Results. Ultrasound examination and evaluation of placental hormonal function indicated that PI is a leading complication in all the women with singleton pregnancy occurring after IVF and ET, regardless of the type of infertility. In this group of the examinees, PI manifested itself as fetal growth restriction in 50.1% of cases; cardiotocographically evidenced mild and severe fetal hypoxia in 76.39 and 9.72%, respectively, impaired fetal placental blood flow in 72.2%, and premature placental aging in 25.1%. The levels of estriol, progesterone, placental growth factor, and placental lactogen were significantly reduced in comparison with those in the control group (p<0.05). In pregnant women after IVF and ET, the compensated form of PI was dominant and identified in 79.1% of cases, its decompensated form was in 20.8% of cases. Conclusion. In women with singleton pregnancy after IVF and ET, the development of the fetoplacental complex is accompanied by PI, by increasing the risk of fetal diseases.