Disturbance of hydrogen sulfide metabolism in the placenta and amniotic fluid in fetal growth retardation

Pogorelova T.N.; Sarkisyan O.G.; Palieva N.V.; Reshetnikova E.A.; Gun’ko V.O.; Krukier I.I.; Nikashina A.A.

doi:https://doi.org/10.17116/rosakush2025250315

Pogorelova T.N.

Rostov State Medical University

SPIN RSCI: 2264-3172
Scopus AuthorID: 16511280700
ORCID: 0000-0002-0400-0652

Sarkisyan O.G.

Rostov State Medical University

ORCID: 0000-0001-5293-986X

Palieva N.V.

Rostov State Medical University

SPIN RSCI: 3309-9218
Scopus AuthorID: 57195261286
ORCID: 0000-0003-2278-5198

Reshetnikova E.A.

Rostov State Medical University

ORCID: 0000-0002-7430-2277

Gun’ko V.O.

Rostov State Medical University

ORCID: 0000-0001-8607-9052

Krukier I.I.

Rostov State Medical University

ORCID: 0000-0003-4570-6405

Nikashina A.A.

Rostov State Medical University

ORCID: 0000-0001-8099-9093

Disturbance of hydrogen sulfide metabolism in the placenta and amniotic fluid in fetal growth retardation

Authors:

Pogorelova T.N., Sarkisyan O.G., Palieva N.V., Reshetnikova E.A., Gun’ko V.O., Krukier I.I., Nikashina A.A.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2025;25(3): 5‑10

DOI: 10.17116/rosakush2025250315

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To cite this article:

Pogorelova TN, Sarkisyan OG, Palieva NV, Reshetnikova EA, Gun’ko VO, Krukier II, Nikashina AA. Disturbance of hydrogen sulfide metabolism in the placenta and amniotic fluid in fetal growth retardation. Russian Bulletin of Obstetrician-Gynecologist. 2025;25(3):5‑10. (In Russ.)
https://doi.org/10.17116/rosakush2025250315

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)

Использование инфографики авторами научных работ

OBJECTIVE

To study the parameters of endogenous hydrogen sulfide metabolism in placenta and amniotic waters in fetal growth retardation (FGR).

MATERIAL AND METHODS

Fifty-six pregnant women were examined in two groups: the 1st (main) group included 30 patients whose pregnancy was complicated by FGR developed because of placental insufficiency, the 2nd (control) group included 26 clinically healthy women with uncomplicated pregnancy and labor. Immunoenzyme analysis, gas-liquid ion-exchange chromatography, spectrophotometric methods were used.

RESULTS

It was found that the content of three main enzymes of hydrogen sulfide synthesis, as well as amino acids cysteine and methionine, which are substrates for its synthesis. In addition, the concentration of their metabolites also changes. At in both studied bioobjects a multidirectional correlation between enzyme activity and amino acids level was found, indicating their close interdependence.

CONCLUSION

Disturbance of hydrogen sulfide metabolism in FGR leads to changes in its multiple functions, including the functions of regulation of cell differentiation, proliferation, apoptosis, which may be accompanied by modification of membrane transport processes and lead to deterioration of fetal trophism.

Keywords:

fetal growth retardation

hydrogen sulfide metabolism

placenta

amniotic waters

Authors:

Pogorelova T.N.

Rostov State Medical University

SPIN RSCI: 2264-3172
Scopus AuthorID: 16511280700
ORCID: 0000-0002-0400-0652

Sarkisyan O.G.

Rostov State Medical University

ORCID: 0000-0001-5293-986X

Palieva N.V.

Rostov State Medical University

SPIN RSCI: 3309-9218
Scopus AuthorID: 57195261286
ORCID: 0000-0003-2278-5198

Reshetnikova E.A.

Rostov State Medical University

ORCID: 0000-0002-7430-2277

Gun’ko V.O.

Rostov State Medical University

ORCID: 0000-0001-8607-9052

Krukier I.I.

Rostov State Medical University

ORCID: 0000-0003-4570-6405

Nikashina A.A.

Rostov State Medical University

ORCID: 0000-0001-8099-9093

Received:

20.12.2024

Accepted:

15.01.2025

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References:

Novikova SV, Tumanova VA, Logutova LS, Petrukhin VA. Compensatory mechanisms of fetal development in conditions of placental insufficiency. Ed. V.I. Krasnopol’skii. Moscow: Medkniga. 2008;298. (In Russ.).
Palieva N.V., Botasheva T.L., Petrov Yu.A., Pogorelova T.N., Drukker N.A., Levkovich M.A., Gun`ko V.O. Features of carbohydrate metabolism and hemostasis system in preeclampsia and fetal growth retardation syndrome in pregnant women with gestational diabetes mellitus. Akusherstvo i ginekologiya. 2021;2:69-76. (In Russ.). https://doi.org/10.18565/aig.2021.2.69-76
Pogorelova TN, Drukker NA, Krukier II, Nikashina AA, Palieva NV, Levkovich MA, Avrutskaya VV. Imbalance of placental cyclic and acyclic nucleotides and modification of their relationship with the exchange of regulatory gas transmitters during premature birth. Russian Bulletin of Obstetrician-Gynecologist. 2023;23:5:13-18. (In Russ.). https://doi.org/10.17116/rosakush20232305113
Strizhakov AN, Ignatko IV, Timokhina EV, Belotserkovtseva LD. Pathophysiology of the fetus and placenta. Moscow: GEOTAR-Media Publ. 2015;176. (In Russ.).
Novikova SV, Tsivtsivadze EB, Leonova VYu, Efanov AA. Opportunities and prospects therapy of placental insufficiency. Effektivnaya farmakoterapiya. 2017;26:22-25.
Gurugubelli KR, Vishnu BB. Molecular mechanisms of intrauterine growth restriction. J Matern Fetal Neonatal Med. 2018;31:19: 2634-2640. https://doi.org/10.1080/14767058.2017.1347922
Yavorskaya SD, Dolgova NS, Fadeeva NI, Anan`ina LP. Maternal clinical and anamnestic factors of fetal growth retardation formation. Voprosy ginekologii, akusherstva i perinatologii. 2019;18:5: 83-87. (In Russ.). https://doi.org/10.20953/1726-1678-2019-5-83-87
Medical laboratory technologies: a guide to clinical laboratory diagnostics. Ed. A.I. Karpishchenko, N.P. Mikhaleva, G.I. Maslova. 3rd ed. Moscow: GEOTAR-Media Publ. 2013;2:788. (In Russ.).
Kolesnikov S.I., Kolesnikova L.I. Hydrogen sulfide as the third essential gas molecule of living tissues. Vestnik RAMN. 2015;70:2: 237-241. (In Russ.). https://doi.org/10.15690/vramn.v70i2.1318
Shibuya N, Mikami Y, Kimura Y, Nagahara N, Kimura H. Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide. J Biochem. 2009;146:5:623-626. https://doi.org/10.1093/jb/mvp111
Kulinskii VI, Kolesnichenko LS. Glutathione of the cell nucleus and its functions. Biomeditsinskaya khimiya. 2010;56:6:657-662. (In Russ.). https://doi.org/10.18097/PBMC20105606657
Pogorelova TN, Nikashina AA, Gun`ko VO, Larichkin AV, Chebotarev DA. Features of redox processes in amniotic fluid in placental insufficiency. Biomeditsinskaya khimiya. 2018;64:3:290-297. (In Russ.). https://doi.org/10.18097/PBMC20186403290
Pogorelova TN, Gun`ko VO, Nikashina AA, Palieva NV, Alliluev IA, Larichkin AV. Violation of the regulation of redox processes in the placenta during its dysfunction. Russian Journal of Human Reproduction. 2019;25:6:112-118. (In Russ.). https://doi.org/10.17116/repro201925061112
Holwerda KM, Karumanchi SA, Lely AT. Hydrogen sulfide: role in vascular physiology and pathology. Curr Opin Nephrol Hypertens. 2015;24:2:170-176. https://doi.org/10.1097/MNH.0000000000000096
Varaksin AA, Pushchina EV. Role of hydrogen sulphide in regulatory functions. Tikhookeanskii meditsinskii zhurnal. 2012;2:27-36. (In Russ.).
Zinchuk VV, Al`-Dzhebur DShO, Glutkina NV. Oxygen-binding properties of blood in insulin resistance with different levels of asprosin. Biomeditsinskaya khimiya. 2023;69:2:133-139. (In Russ.). https://doi.org/10.18097/PBMC20236902133
Lambert IH, Kristensen DM, Holm JB, Mortensen OH. Physiological role of taurine-from organism to organelle. Acta Physiol (Oxf). 2015;213:1:191-212. https://doi.org/10.1111/apha.12365
Desforges M, Parsons L, Westwood M, Sibley CP, Greenwood SL. Taurine transport in human placental trophoblast is important for regulation of cell differentiation and survival. Cell Death Dis. 2013;4:3:e559. https://doi.org/10.1038/cddis.2013.81
Pogorelova TN, Mikhel`son AA, Gun`ko VO, Palieva NV. The importance of hydrolytic destruction of proteins of subcellular fractions of the placenta in the genesis of its dysfunction. Russian Bulletin of Obstetrician-Gynecologist. 2021;21:2:21-25. (In Russ.). https://doi.org/10.17116/rosakush20212102121
Pogorelova TN, Gun`ko VO, Palieva NV, Pelipenko IG, Nikashina AA, Alliluev IA, Larichkin AV. The role of proteomic imbalance in the pathogenesis of fetal growth retardation. Voprosy ginekologii, akusherstva i perinatologii. 2020;19:3:52-56. (In Russ.). https://doi.org/10.20953/1726-1678-2020-3-52-56