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Yakovchuk E.K.

Department of Obstetrics, Gynecology, and Perinatology, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Ministry of Education and Science of the Russian Federation, Simferopol, Russia

Sulima A.N.

Department of Obstetrics, Gynecology, and Perinatology, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Ministry of Education and Science of the Russian Federation, Simferopol, Russia

Rybalka A.N.

Department of Obstetrics, Gynecology, and Perinatology, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Ministry of Education and Science of the Russian Federation, Simferopol, Russia

Dizha M.A.

Department of Obstetrics, Gynecology, and Perinatology, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Ministry of Education and Science of the Russian Federation, Simferopol, Russia

Anikin S.S.

Department of Obstetrics, Gynecology, and Perinatology, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Ministry of Education and Science of the Russian Federation, Simferopol, Russia

Simacheva S.A.

Department of Obstetrics, Gynecology, and Perinatology, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Ministry of Education and Science of the Russian Federation, Simferopol, Russia

Chronic endometritis: State-of-the-art, main aspects of pathogenesis, impact on reproductive function

Authors:

Yakovchuk E.K., Sulima A.N., Rybalka A.N., Dizha M.A., Anikin S.S., Simacheva S.A.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2016;16(5): 37‑41

DOI: 10.17116/rosakush201616537-41

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Table of contents

CHRONIC ENDOMETRITIS: STATE-OF-THE-ART, MAIN ASPECTS OF PATHOGENESIS, IMPACT ON REPRODUCTIVE FUNCTION
CHRONIC ENDOMETRITIS: STATE-OF-THE-ART, MAIN ASPECTS OF PATHOGENESIS, IMPACT ON REPRODUCTIVE FUNCTION

To cite this article:

Yakovchuk EK, Sulima AN, Rybalka AN, Dizha MA, Anikin SS, Simacheva SA. Chronic endometritis: State-of-the-art, main aspects of pathogenesis, impact on reproductive function. Russian Bulletin of Obstetrician-Gynecologist. 2016;16(5):37‑41. (In Russ.)
https://doi.org/10.17116/rosakush201616537-41

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)
 
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The paper analyzes published recent papers on the etiology and pathogenesis of chronic endometritis. The latter is a clinical and morphological syndrome, in which persistent endometrial injury caused by infection results in multiple secondary morphofunctional changes impairing cyclic biotransformation and mucosal receptivity of the corpus uteri. Infertility was diagnosed in 60% of women with verified chronic endometritis. The specific features of chronic endometritis are now the increased significance of the opportunistic microflora, the higher resistance of opportunistic microorganisms to pharmacotherapy, a larger number of subtle forms, and an atypical course. When a chronic inflammatory process occurs in the endometrium, there are the following disorders at the cellular level: metabolic disturbances; immunocompetent system chain breakdown and development of autoimmune processes; impaired steroid hormone receptors expression; formation of a proinflammatory Th1-immune response instead of a Th2-immune response that is needed to successfully develop pregnancy; poorer microcirculation; rises in hypoxia and prooxidant/antioxidant imbalance. The authors declare no conflicts of interest.

Keywords:

chronic endometritis
pathogenesis
reproductive function

Authors:

Yakovchuk E.K.

Department of Obstetrics, Gynecology, and Perinatology, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Ministry of Education and Science of the Russian Federation, Simferopol, Russia

Sulima A.N.

Department of Obstetrics, Gynecology, and Perinatology, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Ministry of Education and Science of the Russian Federation, Simferopol, Russia

Rybalka A.N.

Department of Obstetrics, Gynecology, and Perinatology, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Ministry of Education and Science of the Russian Federation, Simferopol, Russia

Dizha M.A.

Department of Obstetrics, Gynecology, and Perinatology, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Ministry of Education and Science of the Russian Federation, Simferopol, Russia

Anikin S.S.

Department of Obstetrics, Gynecology, and Perinatology, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Ministry of Education and Science of the Russian Federation, Simferopol, Russia

Simacheva S.A.

Department of Obstetrics, Gynecology, and Perinatology, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Ministry of Education and Science of the Russian Federation, Simferopol, Russia

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