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Iashchuk A.G.

Kafedra akusherstva i ginekologii #2 Bashkirskogo gosudarstvennogo meditsinskogo universiteta, Ufa

Tyurina A.A.

Obstetrics and Gynecology Department Two, Bashkir State Medical University, Ufa, Russia

Evaluation of the effect of administration of micronized progesterone and dydrogesterone on the growth of myomatous nodules in pregnant women with uterine myoma

Authors:

Iashchuk A.G., Tyurina A.A.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2016;16(4): 50‑53

DOI: 10.17116/rosakush201616450-53

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Table of contents

EVALUATION OF THE EFFECT OF ADMINISTRATION OF MICRONIZED PROGESTERONE AND DYDROGESTERONE ON THE GROWTH OF MYOMATOUS NODULES IN PREGNANT WOMEN WITH UTERINE MYOMA
EVALUATION OF THE EFFECT OF ADMINISTRATION OF MICRONIZED PROGESTERONE AND DYDROGESTERONE ON THE GROWTH OF MYOMATOUS NODULES IN PREGNANT WOMEN WITH UTERINE MYOMA

To cite this article:

Iashchuk AG, Tyurina AA. Evaluation of the effect of administration of micronized progesterone and dydrogesterone on the growth of myomatous nodules in pregnant women with uterine myoma. Russian Bulletin of Obstetrician-Gynecologist. 2016;16(4):50‑53. (In Russ.)
https://doi.org/10.17116/rosakush201616450-53

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)
 
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Objective - to analyze the effects of micronized progesterone and dydrogesterone on the growth of myomatous nodules during pregnancy in patients with uterine myoma who have delivered via cesarean section with single-stage myomectomy. Subject and methods. The results of examinations of 115 pregnant women with uterine myoma who had delivered via cesarean section with single-stage myomectomy were given. Group 1 included 32 patients with uterine myoma who had pregnancy accompanied with threatened miscarriage in different periods and received therapy with micronized progesterone and dydrogesterone; Group 2 comprised 15 women with uterine myoma, whose pregnancy resulted from in vitro fertilization; Group 3 consisted of 68 pregnant women with uterine myoma who took no drugs. The size, number, and site of myomatous nodules were determined. Myomatous nodule biopsy specimens were immunohistochemically analyzed and the proliferative activity of tumor cells was determined. Results. The sizes of myomatous nodules removed in the women taking micronized progesterone and dydrogesterone during pregnancy were found to be statistically significantly similar to those in the comparison group women. Conclusion. There is evidence that it is expedient to use micronized progesterone and dydrogesterone for the treatment of pregnant women with uterine myoma when the signs of threated miscarriage appear. The authors declare no conflicts of interest.

Keywords:

pregnant women with uterine myoma; threatened miscarriage; treatment; micronized progesterone; dydrogesterone

Authors:

Iashchuk A.G.

Kafedra akusherstva i ginekologii #2 Bashkirskogo gosudarstvennogo meditsinskogo universiteta, Ufa

Tyurina A.A.

Obstetrics and Gynecology Department Two, Bashkir State Medical University, Ufa, Russia

List of references:

  1. Sidorova IS, Unanyan AL, Ageev MB, Vedernikova NV, Zholobova MN. The current state of the question of the pathogenesis, clinical manifestations, diagnosis and treatment of uterine fibroids in women of reproductive age. Akusherstvo, ginekologiya i reprodukciya. 2012;6:4:22-28. (In Russ.).
  2. Ishchenko AI, Botvin MA, Lanchinskii VI. Uterine fibroids: etiology, pathogenesis, diagnosis, treatment. М. 2010;6-9:19-27. (In Russ.).
  3. Davydov AI, Mekhdiev VE, Siordiya AA. Three-dimensional transvaginal sonography in the mode of color and power Doppler: the prospects, opportunities, constraints. Voprosy ginekologii, akusherstva i perinatologii. 2008;7:1:56-64. (In Russ.).
  4. Krasnopol'skii VI, Logutova LS, Buyanova SN. Reproductive problems of operated uterine. Мoscow: Мiklosh. 2005;162. (In Russ.).
  5. Walker CL. Role of hormonal and reproductive factors in the etiology and treatment of uterine leiomyoma. Recent Progress in Hormone Research. 2002;57:277-294.
  6. Levy G, Hill M, Beall S, Zarek S, Segars J, Catherino W. Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advances. J Assisted Reprod Genet. 2012;29:8:703-712.
  7. Kim J, Sefton E. The role of progesterone signaling in the pathogenesis of uterine leiomyoma. Mol Cellular Endocrinol. 2012;358:2:223-231.
  8. Kustarov VN, Tatarov AS. The course of pregnancy, childbirth and the postpartum period in patients with simple and proliferating uterine myoma. Kazanskii meditsinskii zhurnal. 2010;91:3:393-397. (In Russ.).
  9. Buyanova SN, Yudina NV, Gukasyan SA. Modern aspects of uterine fibroid growth. Rossiiskii vestnik akushera-ginekologa. 2012;12:4:42-48. (In Russ.).
  10. Saravelos S, Yan J, Rehmani H, Li T. The prevalence and impact of fibroids and their treatment on the outcome of pregnancy in women with recurrent miscarriage. Human Reprod. 2011;26:12:3274-3279.
  11. Klatsky P, Tran N, Caughey A, Fujimoto V. Fibroids and reproductive outcomes: a systematic literature review from conception to delivery. Am J Obstet Gynecol. 2008;198:4:357-366.
  12. Krasnopol'skii VI, Sergeev PV, Gasparyan ND, Kareva EM, Logutova LS, Buyanova SN, Titchenko LI, Gorbunova TN, Babunashvili EN. Pregnancy and progesterone-dependent leiomyoma uteri. Rossiiskii vestnik akushera-ginekologa. 2003;3:3:5-57. (In Russ.).
  13. Methods of Immunohystokhemistry: Directions. Eds. Kumar GL, Rudbeck L.: DAKO. Translated from English Frank GA, Malkov PG. М. 2011;224. (In Russ.).
  14. Buyanova SN, Gukasyan SA, Yudina NV. Myomectomy during pregnancy: indications, especially surgical tactics and anesthesia, preoperative preparation and rehabilitation. Clinical case. Russkii meditsinskii zhurnal. 2014;22:19:1428-1430. (In Russ.).
  15. de Vivo A, Mancuso A, Giacobbe A, Maggio Savasta L, De Dominici, R, Dugo N, Dugo C and Vaiarelli A. Uterine myomas during pregnancy: a longitudinal sonographic study. Ultrasound Obstet Gynecol. 2011;37:3:361-365.
  16. Lam S, Best S, Kumar S. The impact of fibroid characteristics on pregnancy outcome. Am J Obstet Gynecol. 2014;211:4:395.e1-395.e5.
  17. Shavell V, Thakur M, Sawant A, Kruger M, Jones T, Singh M, Puscheck E and Diamond M. Adverse obstetric outcomes associated with sonographically identified large uterine fibroids. Fertil Steril. 2012;97:1:107-110.
  18. Ciavattini A, Clemente N, Delli Carpini G, Di Giuseppe J, Giannubilo S and Tranquilli A. Number and size of uterine fibroids and obstetric outcomes. J Matern Fetal Neonatal Med. 2015;28:4:484-488.
  19. Hewedi I, Radwan N, Shash L. Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors. Diag Pathol. 2012;7:1:1.
  20. Shi N. Mechanisms simultaneously regulate smooth muscle proliferation and differentiation. J Biomed Res. 2014;28:1:40-46.

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