Objective — to study the results of a follow-up of pregnancy and labor and their management in patients with autoimmune polyglandular syndrome type 1. Subject and methods. Two pregnant women (one of them was gravida II) with this condition characterized by chronic adrenal insufficiency, chronic autoimmune thyroiditis, compensated primary hypothyroidism, compensated primary hypoparathyroidism, and arterial hypotension. The manifestations of the syndrome were detected 2—11 years prior to becoming pregnant. The patients had been receiving hormone replacement therapy for many years, including in the pregravid stage, during pregnancy, and after delivery. The medical histories and case records of the patients were carefully studied; they were examined using clinical, laboratory, instrumental, and molecular genetic studies. Before and during pregnancy, the patients were followed up in large clinical institutions and the required therapy was continuously corrected. Results. The pregnancies were attended by threatened miscarriage and complicated by mild anemia, as well as by gestational pyelonephritis and fetoplacental insufficiency. No symptoms of hypoadrenocorticism were observed during their pregnancies. All the patients delivered their infants via cesarean section. Their postoperative period was uncomplicated. The women and their babies were discharged in satisfactory conditions. The results of a morphological examination of the placentas from the delivered patients were given. Conclusion. Autoimmune polyglandular syndrome type 1, if timely and adequately treated, has no substantial impact on the course of pregnancy in the patients. However, the latter need a careful joint follow-up by a gynecologist and an endocrinologist because of a high risk for decompensation of the disease and a delivery should be performed in a large obstetric facility. The authors declare no conflicts of interest.