The paper describes a difficult clinical case of pregnancy and labor management in a woman with Stage 4B HIV infection and tuberculosis at multiple sites. It outlines the history of the disease, the development of concomitant complications, viral load changes, CD4+ lymphocyte count, and the efficiency of used antiretroviral and antituberculosis therapy regimens. The follow-up of the patient during pregnancy could reveal the specific features of HIV infection and tuberculosis at multiple sites. The efficiency of preventive treatment was proven by the birth of a healthy HIV-negative full-term baby.