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Korkmazov M.Yu.

South Ural State Medical University

Kazachkov E.L.

South Ural State Medical University

Lengina M.A.

South Ural State Medical University

Dubinets I.D.

South Ural State Medical University

Korkmazov A.M.

South Ural State Medical University

Cause-effect factors of rhinosinusitis poliposa development

Authors:

Korkmazov M.Yu., Kazachkov E.L., Lengina M.A., Dubinets I.D., Korkmazov A.M.

More about the authors

Journal: Russian Rhinology. 2023;31(2): 124‑130

DOI: 10.17116/rosrino202331021124

Read: 2146 times

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Table of contents

CAUSE-EFFECT FACTORS OF RHINOSINUSITIS POLIPOSA DEVELOPMENT
CAUSE-EFFECT FACTORS OF RHINOSINUSITIS POLIPOSA DEVELOPMENT

To cite this article:

Korkmazov MYu, Kazachkov EL, Lengina MA, Dubinets ID, Korkmazov AM. Cause-effect factors of rhinosinusitis poliposa development. Russian Rhinology. 2023;31(2):124‑130. (In Russ.)
https://doi.org/10.17116/rosrino202331021124

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The research rationale of pathogenetic mechanisms of rhinosinusitis poliposa is determined by the wide prevalence, social significance and low treatment efficacy of this disease.

OBJECTIVE

The aim of the study is generalization and analysis of current data on pathogenesis of rhinosinusitis poliposa.

MATERIAL AND METHODS

The analysis of scientific publications presented in Scopus, Web of Science, Medline, RSCI, eLIBRARY.RU databases for the period 2012—2022 was done. The choice of material was made according to the key words: rhinosinusitis poliposa, etiology, pathogenesis, nasal polyposis.

RESULTS AND CONCLUSION

Numerous studies have confirmed the multifactority of mechanisms, involved in the development of rhinosinusitis poliposa. Nasal polyps are formed by interaction with environmental factors of acquired or congenital biological defects. At the same time, the following factors play an important role in the pathogenesis of rhinosinusitis poliposa: disorders of air flow’s aerodynamics in the nasal passages; chronic pyogenic rhinosinusitis, fungal lesion of nasal mucosa; cystic fibrosis; disorders of the metabolism of arachidonic acid; Cartagener syndrome. The lack of a unified view on pathogenetic factors makes it difficult to predict the course of a disease and develop effective treatment algorithms. Further in-depth research of this issue is required.

Keywords:

rhinosinusitis poliposa
etiology
pathogenesis
nasal polyposis

Authors:

Korkmazov M.Yu.

South Ural State Medical University

Kazachkov E.L.

South Ural State Medical University

Lengina M.A.

South Ural State Medical University

Dubinets I.D.

South Ural State Medical University

Korkmazov A.M.

South Ural State Medical University

Received:

21.09.2022

Accepted:

21.02.2023

List of references:

  1. Khan A, Vandeplas G, Huynh TMT, Joish VN, Mannent L, Tomassen P, Van Zele T, Cardell LO, Arebro J, Olze H, Foerster-Ruhrmann U, Kowalski ML, Olszewska-Ziaber A, Holtappels G, De Ruyck N, van Drunen C, Mullol J, Hellings PW, Hox V, Toskala E, Scadding G, Lund VJ, Fokkens WJ, Bachert C. The Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort: A large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps. Rhinology. 2019;57(1):32-42.  https://doi.org/10.4193/Rhin17.255
  2. Savlevich EL, Gaganov EL, Egorov VI, Kurbacheva OM, Gerasimov AN, Shachnev KN. A comparative pilot study of antipov polosnogo chronic rhinosinusitis patients living in different geographical regions of the Russian Federation. Immunologiya. 2018;39(4):208-213. (In Russ.).
  3. Moiseeva YuP, Piskunov GZ. Participation of sex hormones in formation of nasal polyps. Background. Rossiiskaya rinologiya. 2019;27(4):200-203. (In Russ.). https://doi.org/10.17116/rosrino201927041200
  4. Nosulya EV, Kim IA, Afanasyeva NV, Symbaeva OV. Polypous sinusitis prevalence among urban population of Eastern Siberia. Rossiiskaya rinologiya. 2007;1:4-8. (In Russ.).
  5. Kim IA, Nosulya EV, Ragimova DR. Features of adherence to treatment of patients with chronic rhinosinusitis with nasal polyps. Vestnik otorinolaringologii. 2022;87(1):81-86. (In Russ.). https://doi.org/10.17116/otorino20228701181
  6. Piskunov GZ. Polyposis of the nose, paranasal sinuses and its treatment. Rossijskaya rinologiya. 2003;2:10-13. Accessed March 24, 2023. (In Russ.). https://www.mediasphera.ru/issues/rossijskaya-rinologiya/2019/4/downloads/ru/1086954742019041224
  7. Piskunov GZ, Aref’eva NA, Karpishchenko SA, Karpova EP, Lopatin AS, Moiseeva YuP, Semenov FV, Shilenkova VV. Polypous rhinosinusitis (clinical guidelines). Moscow: Russian Society of Rhinologists; 2022. Accessed March 24, 2023. (In Russ.). https://rhinology.ru/2022/10/01/klinicheskie-rekomendacii-rossijskogo-obshhestva-rinologov-polipoznyj-rinosinusit/
  8. Polypous rhinosinusitis (clinical guidelines). M.: National Medical Association of Otorhinolaryngologists; 2019. Accessed March 24, 2023. (In Russ.). https://www.vodkb.ru/wp-content/uploads/pages/documents/klin-recomend/Polipoznyj-rinosinusit19.pdf
  9. Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, Toppila-Salmi S, Bernal-Sprekelsen M, Mullol J, Alobid I, Terezinha Anselmo-Lima W, Bachert C, Baroody F, von Buchwald C, Cervin A, Cohen N, Constantinidis J, De Gabory L, Desrosiers M, Diamant Z, Douglas RG, Gevaert PH, Hafner A, Harvey RJ, Joos GF, Kalogjera L, Knill A, Kocks JH, Landis BN, Limpens J, Lebeer S, Lourenco O, Meco C, Matricardi PM, O’Mahony L, Philpott CM, Ryan D, Schlosser R, Senior B, Smith TL, Teeling T, Tomazic PV, Wang DY, Wang D, Zhang L, Agius AM, Ahlstrom-Emanuelsson C, Alabri R, Albu S, Alhabash S, Aleksic A, Aloulah M, Al-Qudah M, Alsaleh S, Baban MA, Baudoin T, Balvers T, Battaglia P, Bedoya JD, Beule A, Bofares KM, Braverman I, Brozek-Madry E, Richard B, Callejas C, Carrie S, Caulley L, Chussi D, de Corso E, Coste A, El Hadi U, Elfarouk A, Eloy PH, Farrokhi S, Felisati G, Ferrari MD, Fishchuk R, Grayson W, Goncalves PM, Grdinic B, Grgic V, Hamizan AW, Heinichen JV, Husain S, Ping TI, Ivaska J, Jakimovska F, Jovancevic L, Kakande E, Kamel R, Karpischenko S, Kariyawasam HH, Kawauchi H, Kjeldsen A, Klimek L, Krzeski A, Kopacheva Barsova G, Kim SW, Lal D, Letort JJ, Lopatin A, Mahdjoubi A, Mesbahi A, Netkovski J, Nyenbue Tshipukane D, Obando-Valverde A, Okano M, Onerci M, Ong YK, Orlandi R, Otori N, Ouennoughy K, Ozkan M, Peric A, Plzak J, Prokopakis E, Prepageran N, Psaltis A, Pugin B, Raftopulos M, Rombaux P, Riechelmann H, Sahtout S, Sarafoleanu CC, Searyoh K, Rhee CS, Shi J, Shkoukani M, Shukuryan AK, Sicak M, Smyth D, Sindvongs K, Soklic Kosak T, Stjarne P, Sutikno B, Steinsvag S, Tantilipikorn P, Thanaviratananich S, Tran T, Urbancic J, Valiulius A, Vasquez de Aparicio C, Vicheva D, Virkkula PM, Vicente G, Voegels R, Wagenmann MM, Wardani RS, Welge-Lussen A, Witterick I, Wright E, Zabolotniy D, Zsolt B, Zwetsloot CP. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology. 2020;58(S29 suppl):1-464.  https://doi.org/10.4193/Rhin20.600
  10. Piskunov GZ. Polipoznyi rinosinusit. M.: GEOTAR-Media; 2020. (In Russ.).
  11. Korkmazov MYu, Kornova NV, Chin’kov NA. The nature of cephalgia in acute and chronic sinusitis, their impact on the quality of life. Rossiiskaya otorinolaringologiya. 2009;2:96-101. (In Russ.).
  12. Ryazantsev SV, Artyushkina VK, Nacharov PV, Laptijova MA. Modern aspects of systemic corticosteroid therapy in patients with chronic rhinosinusitis with nasal polyps. Rossiiskaya otorinolaringologiya. 2013;2:114-121. Accessed March 24, 2023. (In Russ.). https://cyberleninka.ru/article/n/sovremennye-aspekty-sistemnoy-kortikosteroidnoy-terapii-u-bolnyh-hronicheskim-polipoznym-rinosinusitom-obzor-literatury
  13. Bezrukova EV, Khmel’nitskaya NM, Aflitonov MA. The present-day aspects of chronic polypous rhinosinusitis immunopathogenesis. Rossiiskaya otorinolaringologiya. 2017;3:16-23. (In Russ.). https://doi.org/10.18692/1810-4800-2017-3-16-23
  14. Chaaban MR, Walsh EM, Woodworth BA. Epidemiology and differential diagnosis of nasal polyps. American journal of rhinology & allergy. 2013;27(6):473-478.  https://doi.org/10.2500/ajra.2013.27.3981
  15. Khaitov MR, Dyneva ME, Savlevich EL, Kudlay DA, Gaysina AR, Nikolsky AA, Shilovsky IP, Kurbacheva OM. Asthma associated with nasal polyps: clinical characteristics and analysis of local expression of IL37 gene. Immunologiya. 2020;41(1):54-63. (In Russ.). https://doi.org/10.33029/0206-4952-2020-41-1-54-63
  16. Khmelkova EV. Comparative assessment of surgical and conservative treatment of polypous rhynosinusitis accompanied with bronchial asthma. Byulleten’ fiziologii i patologii dykhaniya. 2006;S22:46-48. (In Russ.).
  17. Sukhachev PA, Sergeev OS, Prokhorenko IO, Panina MI. Morphology of nasal polyps in patients with altered immunological reactivity. Morfologicheskie vedomosti. 2017;25(4):22-26. (In Russ.). https://doi.org/10.20340/mv-mn.2017(25).4.22-26
  18. Schneider JS. Subcutaneous Dupilumab and Mometasone Furoate Nasal Spray for Chronic Rhinosinusitis With Polyps. JAMA Otolaryngology — Head & Neck Surgery. 2016;142(7):698-699.  https://doi.org/10.1001/jamaoto.2016.0678
  19. Korkmazov MYu, Dubinets ID, Lengina MA, Korkmazov AM, Kornova NV, Ryabenko YuI. Certain indicators of immunological reactivity in surgical alteration of ENT organs. Russian Immunological Journal. 2022;25(2):201-206. (In Russ.). https://rusimmun.ru/jour/article/view/1121/957/ru_RU
  20. Gevaert P, Calus L, Van Bruaene N, Van Zele T, Bachert C. Allergic sensitization, high local IL-5 and IgE predict surgical outcome 12 years after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis. The Journal of allergy and clinical immunology. 2015;135(2):AB238. https://doi.org/10.1016/j.jaci.2014.12.1713
  21. Gisinger OA, Korkmazov AM, Korkmazov MYu. The state of antimicrobial protection factors of nasal secretion in patients operated on the curvature of the nasal septum in the early postoperative period. Rossiiskii immunologicheskii zhurnal. 2017;11(20):117-119. Accessed March 24, 2023. (In Russ.). https://www.elibrary.ru/contents.asp?issueid=1883625
  22. Vlaminck S, Vauterin T, Hellings PW, Jorissen M, Acke F, Van Cauwenberge P, Bachert C, Gevaert P. The importance of local eosinophilia in the surgical outcome of chronic rhinosinusitis. American Journal of Rhinology and Allergy. 2014;28(3):260-264.  https://doi.org/10.2500/ajra.2014.28.4022
  23. Gadzhimirzaev GA, Gadzhimirzaeva RG. Some unresolved and controversial issues and problems of polypous rhinosinusitis. Rossiiskaya otorinolaringologiya. 2018;5(96):23-26. (In Russ.). https://doi.org/10.18692/1810-4800-2018-5-23-26
  24. Stevens WW, Peters AT, Suh L, Norton JE, Kern RC, Conley DB, Chandra RK, Tan BK, Grammer LC, Harris KE, Carter RG, Kato A, Urbanek M, Schleimer RP, Hulse KE. A retrospective, cross-sectional study reveals that women with CRSwNP have more severe disease than men. Immunity, Inflammation and Disease. 2015;3(1):14-22.  https://doi.org/10.1002/iid3.46
  25. Korkmazov MYu, Lengina MA, Dubinets ID, Korkmazov AM, Smirnov AA. Opportunities for correction of individual links of the pathogenesis of allergic rhinitis and bronchial asthma with assessment of the quality of life of patients. Meditsinskii sovet. 2022;16(4):24-34. (In Russ.). https://doi.org/10.21518/2079-701X-2022-16-4-24-34
  26. Shishkin AA, Karakulova YuV, Voronchikhina NV. The state of the serotonin system in the patients presenting with chronic polypous rhinosinusitis. Vestnik otorinolaringologii. 2017;82(6):15-17. (In Russ.). https://doi.org/10.17116/otorino201782615-17
  27. Karpishchenko SA, Ryabova MA, Shumilova NA. Conservative treatment for rhinosinusitis polypous. Effektivnaya farmakoterapiya. 2016;20:6-9. (In Russ.).
  28. Korkmazov MYu, Solodovnik AV, Korkmazov AM, Lengina MA. Perspectives on the use of a herbal preparation in combination with physical methods in complex therapy of chronic adenoiditis. Medical advice. 2021;18:19-27. (In Russ.). https://doi.org/10.21518/2079-701X-2021-18-19-27
  29. Dobrynin KB, Portenko GM, Miller DA. Etiopathogenetic aspects of polypous rhinosinusitis. Rossiiskaya rinologiya. 2012;3:31. (In Russ.).
  30. Blotskiĭ AA, Blotskiĭ RA, Chaĭka VV, Golokhvast KS. The morphofunctional state of the polypous tissue under conditions of radiofrequency-wave and laser interstitial thermal therapy. Vestnik otorinolaringologii. 2014;4:13-16. (In Russ.).
  31. Savlevich EL, Kurbacheva OM, Egorov VI, Dyneva ME, Shilovskiy IP, Khaitov MR. Gene expression levels of cytokines in different phenotypes of CRSwNP. Vestnik otorinolaringologii. 2019;84(6):42-47. (In Russ.). https://doi.org/10.17116/otorino20198406142
  32. Bequignon E, Mangin D, Bécaud J, Pasquier J, Angély C, Bottier M, Escudier E, Isabey D, Filoche M, Louis B, Papon J, Coste A. Pathogenesis of chronic rhinosinusitis with nasal polyps: role of IL-6 in airway epithelial cell dysfunction. Journal of Translational Medicine. 2020;18(1):136.  https://doi.org/10.1186/s12967-020-02309-9
  33. Chen X, Chang L, Li X, Huang J, Yang L, Lai X, Huang Z, Wang Z, Wu X, Zhao J, Bellanti JA, Guo Zheng S, Zhang G. Tc17/IL-17A Up-Regulated the Expression of MMP-9 via NF-κB Pathway in Nasal Epithelial Cells of Patients With Chronic Rhinosinusitis. Frontiers in Immunology. 2018;9:2121. https://doi.org/10.3389/fimmu.2018.02121
  34. Chiarella E, Lombardo N, Lobello N, Aloisio A, Aragona T, Pelaia C, Scicchitano S, Mandy Bond H, Mesuraca M. Nasal Polyposis: Insights in Epithelial-MesenchymalTransition and Differentiation of Polyp Mesenchymal Stem Cells. International Journal of Molecular Sciences. 2020;21:6878. https://doi.org/10.3390/ijms21186878
  35. Levchenko AS, Mezentseva OYu, Piskunov VS, Polonikov AV. Interrelation of IL1B and IL6 genes polymorphism with blood eosinophilia and histological picture of polyps in patients with chronic polypous rhinosinusitis. Nauchnye rezul’taty biomeditsinskikh issledovanii. 2021;7(4):363-374. (In Russ.). https://doi.org/10.18413/2658-6533-2021-7-4-0-3
  36. Moiseeva YuP, Piskunov GZ. Molecular genetic aspects of polypous rhinosinusitis. Rossiiskaya rinologiya. 2020;28(1):26-31. (In Russ.). https://doi.org/10.17116/rosrino20202801126
  37. Moiseeva YuP, Piskunov GZ. Influence of IL-33 gene polymorphisms on formation of clinical phenotypes of polyposis rhinosinusitis. Rossiiskaya rinologiya. 2020;28(4):205-210. (In Russ.). https://doi.org/10.17116/rosrino202028041205
  38. Matveeva NYu, Pavlush DG, Kalinichenko SG. Expression of pro- and anti-apoptotic molecules in the mucous membrane of the nasal cavity with polypous rhinosinusitis. Vestnik otorinolaringologii. 2020;85(3):43-47. (In Russ.). https://doi.org/10.17116/otorino20208503143
  39. Tomassen P, Vandeplas G, Van Zele T, Cardell LO, Arebro J, Olze H, Förster-Ruhrmann U, Kowalski MLOlszewska-Ziąber A, Holtappels G, De Ruyck N, Wang X, Van Drunen C, Mullol J, Hellings P, Hox V, Toskala E, Scadding G, Lund V, Zhang L, Fokkens W, Bachert C. Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers. Journal of Allergy and Clinical Immunology. 2016;137(5):1449-1456. https://doi.org/10.1016/j.jaci.2015.12.1324
  40. Kochetkov PA, Rakunova EB. Treatment features of chronic rhinisinusitis in patients with perennial allergic rhinitis. Meditsinskii sovet. 2018;8:78-82. (In Russ.). https://doi.org/10.21518/2079-701X-2018-8-78-82
  41. Marfani MS, Jawaid MA, Shaikh SM, Thaheem K. Allergic fungal rhinosinusitis with skull base and orbital erosion. The Journal of Laryngology & Otology. 2010;124(2):161-165.  https://doi.org/10.1017/S0022215109991253
  42. Ryazantsev SV, Budkovaya MA. Current view of the treatment of chronic rhinosinusitis with nasal polyps. Rossiiskaya rinologiya. 2017;25(1):54-56. (In Russ.). https://doi.org/10.17116/rosrino201725154-59
  43. Korkmazov MYu, Dubinets ID, Lengina MA, Solodovnic AV. Local concentrations of secretory immunoglobulin a in patients with adenoiditis, rhinosinusitis and exacerbation of chronic purulent otitis media when using physiatric methods in complex therapy. Rossiiskii immunologicheskii zhurnal. 2021;24(2):297-304. (In Russ.). https://doi.org/10.46235/1028-7221-999-LCO
  44. Lima JT, Paula FE, Proença-Modena JL, DeMarco R, Buzatto G, Saturno TH, Delcaro L, Tamashiro E, Valera F, Arruda E, Anselmo-Lima W. The seasonality of respiratory viruses in patients with chronic rhinosinusitis. American Journal of Rhinology & Allergy. 2015;29(1):19-22.  https://doi.org/10.2500/ajra.2015.29.4129
  45. Lazareva AM, Smirnova SV, Kolenchukova OA. Comparative characteristics of the nasal mucosa microflora at different level of allergic inflammation in the respiratory tract. Infektsiya i immunitet. 2022;12(2):331-338. (In Russ.). https://doi.org/10.15789/2220-7619-CCO-1677
  46. Korkmazov MYu, Lengina MA, Korkmazov AM. Biochemical parameters of the nature of oxidative stress depending on the postoperative therapy in patients undergoing intranasal surgical interventions. Bulletin of Otorhinolaryngology. 2016;81(S5):33-35. Accessed March 24, 2023. (In Russ.). https://www.elibrary.ru/item.asp?id=32283511
  47. Mel’nik AM, Voronov AV, Dvoryanchikov VV, Isachenko VS, Achba RR. The condition of nasal cavity microflora in polypous rhinosinusitis. Rossiiskaya otorinolaringologiya. 2017;1(86):73-82. Accessed March 24, 2023. (In Russ.). https://cyberleninka.ru/article/n/sostoyanie-mikroflory-polosti-nosa-pri-polipoznom-rinosinusite
  48. Anderson M, Stokken J, Sanford T, Aurora R, Sindwani R. A systematic review of the sinonasal microbiome in chronic rhinosinusitis. American Journal of Rhinology and Allergy. 2016;30(3):161-166.  https://doi.org/10.2500/ajra.2016.30.4320
  49. Bondareva GP, Turovsky AB, Semkina OV. The role of staphylococcus aureus in nasal polyposis. Rossiiskii allergologicheskii zhurnal. 2013;6:5-8. (In Russ.).
  50. Chen J-B, James LK, Davies AM, Bryan Wu Y-C, Rimmer J, Lund VJ, Chen J-H, McDonnell JM, Chan Y-C, Hutchins GH, Wen Chang T, Sutton BJ, Kariyawasam HH, Gould HJ. Affiliations Expand Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps. The Journal of Allergy and Clinical Immunology. 2017;139(4):1195-1204. https://doi.org/10.1016/j.jaci.2016.06.066
  51. Vinnikova NV. Specific features of the microflora of the nasal cavity in patients with polypous. Rossiiskaya rinologiya. 2015;23(1):13-15. (In Russ.). https://doi.org/10.17116/rosrino201523113-15
  52. Talibov AKh, Korkmazov MYu, Lengina MA, Krivopalov AA, Grishaev NV. Personified approach to improving the quality of life and psychophysical readiness of kettlebell lifting athletes by correcting sensory and vasomotor disorders of ORL-organs. Man. Sport. Medicine. 2021;21(4):29-41. Accessed March 24, 2023. (In Russ.). https://hsm.susu.ru/hsm/ru/issue/view/33
  53. Pavlush DG, Pavlush EN, Matveeva NU, Kalinichenko SG, Dyuizen IV. Chronic polyposis rhinosinusitis: etiopathogenetic mechanisms of its occurrence. Meditsina. 2018;6(2):69-78. (In Russ.). https://doi.org/10.29234/2308-9113-2018-6-2-69-78
  54. Pavlush DG, Dyuizen IV. Inflammatory markers in the nasal mucosa and polyp-modified tissues in chronic rhinosinusitis with nasal polyps. Klinicheskaya i eksperimental’naya morfologiya. 2021;10(3):29-38. (In Russ.). https://doi.org/10.31088/CEM2021.10.3.29-38
  55. Piskunov GZ, Abdulaev BA, Kim IA. Role of intranasal structures disorders in the development of polypous rhinosinusitis. Russian rhinology. 2014;22(4):13-20. Accessed March 24, 2023. (In Russ.). https://www.mediasphera.ru/issues/rossijskaya-rinologiya/2014/4/030869-5474201443
  56. Carroll WW, Schlosser RJ, O’Connell BP, Soler ZM, Mulligan JK. Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps. International Forum of Allergy & Rhinology. 2016;6(6):605-610.  https://doi.org/10.1002/alr.21704
  57. Ryazantsev SV, Lopatin AS, Piskunov GZ, Karneeva OV. Polipoznyi rinosinusit. Klinicheskie rekomendatsii. Moscow-Saint Petersburg: Nacional’naya medicinskaya associaciya otorinolaringologov; 2014. Accessed September 19, 2022. (In Russ.). https://lornii.ru/upload/iblock94e/%D0%9F%D0%BE%D0%BB%D0%B8%D0%BF%D0%BE%D0%B7%D0%BD%D1%8B%D0%B9%20%D1%80%D0%B8%D0%BD%D0%BE%D1%81%D0%B8%D0%BD%D1%83%D1%81%D0%B8%D1%82.%20pdf
  58. Piskunov GZ. Clinical phenotypes of polypous rhinosinusitis. Russian rhinology. 2019;27(4):224-231. (In Russ.). https://doi.org/10.17116/rosrino201927041224
  59. Abdullaev BA. The features of treatment of first diagnosed polypous rhinisinusitis. Rossiiskaya rinologiya. 2010;18(4):12-15. (In Russ.).

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